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pro vyhledávání: '"Nathan Hugo Epalle"'
Local Attraction of Substrates and Co-Substrates Enhances Weak Acid and Base Transmembrane Transport
Autor:
Nathan Hugo Epalle, Eric Beitz
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1794 (2022)
The transmembrane transport of weak acid and base metabolites depends on the local pH conditions that affect the protonation status of the substrates and the availability of co-substrates, typically protons. Different protein designs ensure the attra
Externí odkaz:
https://doaj.org/article/58cafde79a4542a4b9f4b877e1e27fcd
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249110 (2021)
Transmembrane transport of l-lactate by members of the monocarboxylate transporter family, MCT, is vital in human physiology and a malignancy factor in cancer. Interaction with an accessory protein, typically basigin, is required to deliver the MCT t
Externí odkaz:
https://doaj.org/article/f0df9f33e99a479fb9b81bf0336233a8
Autor:
Iga Jakobowska, Frank Becker, Stefano Minguzzi, Kerrin Hansen, Björn Henke, Nathan Hugo Epalle, Eric Beitz, Stefan Hannus
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 757 (2021)
Blocking lactate export in the parasitic protozoan Plasmodium falciparum is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. The pe
Externí odkaz:
https://doaj.org/article/5aa87a5ca06b4543a7a20fec80386a82
Autor:
Romain Linares, Charles-Adrien Arnaud, Grégory Effantin, Claudine Darnault, Nathan Hugo Epalle, Elisabetta Boeri Erba, Guy Schoehn, Cécile Breyton
Publikováno v:
Science Advances
Science Advances, 2023, 9 (12), pp.eade9674. ⟨10.1126/sciadv.ade9674⟩
Science Advances, 2023, 9 (12), pp.eade9674. ⟨10.1126/sciadv.ade9674⟩
The vast majority of bacteriophages (phages) - bacterial viruses - present a tail that allows host recognition, cell wall perforation and safe channelling of the viral DNA from the capsid to the cytoplasm of the infected bacterium. The majority of ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14528f8d4381b813e2cb5f48bb2495fa
https://doi.org/10.1101/2022.09.20.507954
https://doi.org/10.1101/2022.09.20.507954
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0249110 (2021)
PLOS ONE
PLoS ONE, Vol 16, Iss 3, p e0249110 (2021)
PLOS ONE
Transmembrane transport ofl-lactate by members of the monocarboxylate transporter family, MCT, is vital in human physiology and a malignancy factor in cancer. Interaction with an accessory protein, typically basigin, is required to deliver the MCT to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6218894199df6bccce88993fb38e63b
https://pubmed.ncbi.nlm.nih.gov/33770122
https://pubmed.ncbi.nlm.nih.gov/33770122
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 1191, p 1191 (2021)
Pharmaceuticals, Vol 14, Iss 1191, p 1191 (2021)
Plasmodium spp. malaria parasites in the blood stage draw energy from anaerobic glycolysis when multiplying in erythrocytes. They tap the ample glucose supply of the infected host using the erythrocyte glucose transporter 1, GLUT1, and a hexose trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbab13007e83e1fa6f2e64995e108dd
https://doi.org/10.3390/ph14111191
https://doi.org/10.3390/ph14111191