Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nathan Guerin"'
Autor:
Valentina Kugler, Andreas Lieb, Nathan Guerin, Bruce R. Donald, Eduard Stefan, Teresa Kaserer
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-6 (2023)
Abstract We report an Osprey-based computational protocol to prospectively identify oncogenic mutations that act via disruption of molecular interactions. It is applicable to analyse both protein-protein and protein-DNA interfaces and it is validated
Externí odkaz:
https://doaj.org/article/44c54c3e1e4348bb8e98e527dd1bde73
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102170- (2023)
Summary: Prospective predictions of drug-resistant protein mutants could improve the design of therapeutics less prone to resistance. Here, we describe RESISTOR, an algorithm that uses structure- and sequence-based criteria to predict resistance muta
Externí odkaz:
https://doaj.org/article/df344fed3a654445bfa3fdf244d3ff39
Publikováno v:
Journal of Computational Biology. 29:1346-1352
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630ad0ed78ea6d02a6abdbda96e8d702
https://doi.org/10.1089/cmb.2022.0254
https://doi.org/10.1089/cmb.2022.0254
Publikováno v:
In Solar Energy May 2013 91:186-195
Resistance to pharmacological treatments is a major public health challenge. Here we report Resistor—a novel structure- and sequence-based algorithm for drug design providing prospective prediction of resistance mutations. Resistor computes the Par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e99766e9f325937cbd7dfbe2117a16b2
https://doi.org/10.1101/2022.01.18.476733
https://doi.org/10.1101/2022.01.18.476733
Publikováno v:
Cell Systems. 13:830-843.e3
Resistance to pharmacological treatments is a major public health challenge. Here, we introduce Resistor-a structure- and sequence-based algorithm that prospectively predicts resistance mutations for drug design. Resistor computes the Pareto frontier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ceb6a48f2f272b519c292179817be1
https://doi.org/10.1016/j.cels.2022.09.003
https://doi.org/10.1016/j.cels.2022.09.003