Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Nathan G Skene"'
Autor:
Kenneth D Harris, Hannah Hochgerner, Nathan G Skene, Lorenza Magno, Linda Katona, Carolina Bengtsson Gonzales, Peter Somogyi, Nicoletta Kessaris, Sten Linnarsson, Jens Hjerling-Leffler
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2006387 (2018)
Understanding any brain circuit will require a categorization of its constituent neurons. In hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to date. However, this list may be incomplete; additionally, it is unclear w
Externí odkaz:
https://doaj.org/article/ccf484a2854f4fbdad2326e2044d9008
Publikováno v:
eLife, Vol 6 (2017)
The genetic mechanisms regulating the brain and behaviour across the lifespan are poorly understood. We found that lifespan transcriptome trajectories describe a calendar of gene regulatory events in the brain of humans and mice. Transcriptome trajec
Externí odkaz:
https://doaj.org/article/abb53584a758407eb234ffdf29f59d44
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Despite calls to improve reproducibility in research, achieving this goal remains elusive even within computational fields. Currently, >50% of R packages are distributed exclusively through GitHub. While the trend towards sharing open-source
Externí odkaz:
https://doaj.org/article/a11a3cccc3cb411ab4f7c0f7d3122975
Autor:
Alan E. Murphy, Nathan G. Skene
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/4b68b24be04240469d935c5ac5966ff6
Arising FromMathys, H.et al. Nature (2019).https://doi.org/10.1038/s41586-019-1195-2Mathyset al., conducted the first single-nucleus RNA-Seq study (snRNA-Seq) of Alzheimer’s disease (AD)1. The authors profiled the transcriptomes of approximately 80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8dce3855bb784211679003adf70be5c
https://doi.org/10.1101/2023.04.01.535040
https://doi.org/10.1101/2023.04.01.535040
Autor:
Kitty B. Murphy, Robert Gordon-Smith, Jai Chapman, Momoko Otani, Brian M. Schilder, Nathan G. Skene
Rare diseases (RDs) are uncommon as individual diagnoses, but as a group contribute to an enormous disease burden globally. However, partly due the low prevalence and high diversity of individual RDs, this category of diseases is understudied and und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f122c5094175db70d6c3f697ca0c6b63
https://doi.org/10.1101/2023.02.13.23285820
https://doi.org/10.1101/2023.02.13.23285820
Reproducibility is essential to the progress of research, yet achieving it remains elusive even in computational fields. Continuous Integration (CI) platforms offer a powerful way to launch automated workflows to check and document code, but often re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1deff2334cc6f810f60ffa0693ea9a4b
https://doi.org/10.21203/rs.3.rs-2399015/v1
https://doi.org/10.21203/rs.3.rs-2399015/v1
Publikováno v:
Bioinformatics Advances. 3
SummaryEpiCompare combines a variety of downstream analysis tools to compare, quality control and benchmark different epigenomic datasets. The package requires minimal input from users, can be run with just one line of code and provides all results o
Publikováno v:
Bioinformatics
Motivation Genome-wide association studies (GWAS) summary statistics have popularized and accelerated genetic research. However, a lack of standardization of the file formats used has proven problematic when running secondary analysis tools or perfor
Autor:
Jennie Olofsson, Peter Lönnerberg, Caroline Ingre, Elena Rodriguez-Vieitez, Inci Sevval Aksoylu, Caroline Mijnsbergen, Manuela Lehmann, Jan H. Veldink, Inti von Gohren Antequera, Albert C. Ludolph, Anna Szczepińska, Stefan Wouters, Mathias Uhlén, Ulf Kläppe, Eleonora Aronica, Hermieneke Vergunst-Bosch, Anna Månberg, Julia Remnestål, Sebastian A. Lewandowski, Lwaki Ebarasi, Peter Nilsson, Aylin Domaniku, Robert A. Harris, Nathan G. Skene, Jasper J. Anink, Joke De Vocht, Eva Hedlund, Annemarie Hübers, Koen Poesen, Philip Van Damme, Marta Trusohamn, Jonathan D. Gilthorpe, Maxim De Schaepdryver, Folkert Sanders
Publikováno v:
Nature medicine, 27(4), 640-646. Nature Publishing Group
Nat Med
Nature medicine 27(4), 640-646 (2021). doi:10.1038/s41591-021-01295-9
Nat Med
Nature medicine 27(4), 640-646 (2021). doi:10.1038/s41591-021-01295-9
Apart from well-defined factors in neuronal cells1, only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia2,3 and blood vessels4. In this study w