Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nathan E. Grega-Larson"'
Publikováno v:
Molecular Biology of the Cell
Apical microvilli are critical for the homeostasis of transporting epithelia, yet mechanisms that control the assembly and morphology of these protrusions remain poorly understood. Previous studies in intestinal epithelial cell lines suggested a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95143e1806fd9f22729e3da1af10637c
http://europepmc.org/articles/PMC6743356
http://europepmc.org/articles/PMC6743356
Publikováno v:
Current Opinion in Cell Biology. 44:68-78
Unconventional myosins are actin-based molecular motors that serve a multitude of roles within the cell, contributing to cell shape and function. One group of myosin motors, MyTH4-FERM myosins, plays an integral part in building and maintaining finge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d2baec307e98a8fb449996151be8be
https://doi.org/10.1016/j.ceb.2016.10.002
https://doi.org/10.1016/j.ceb.2016.10.002
Publikováno v:
Cytoskeleton. 73:670-679
Cordon-bleu (COBL) is a multifunctional WASP-Homology 2 (WH2) domain-containing protein implicated in a wide variety of cellular functions ranging from dendritic arborization in neurons to the assembly of microvilli on the surface of transporting epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97135e144142a31b85dd0d3c9c48b4da
https://doi.org/10.1002/cm.21317
https://doi.org/10.1002/cm.21317
Autor:
Nathan E. Grega-Larson, Motoharu Seiki, Seema Sinha, Daisuke Hoshino, Matthew J. Tyska, Alissa M. Weaver, Kellye C. Kirkbride, Nan Hyung Hong
Publikováno v:
The Journal of Cell Biology
Sinha et al. show that the cytoskeletal and tumor-overexpressed protein cortactin promotes secretion of exosomes from cancer cells by stabilizing dynamic cortical actin docking sites for multivesicular endosomes, suggesting a potential mechanism by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfcd57b297852718151d383158c66e7
https://doi.org/10.1083/jcb.201601025
https://doi.org/10.1083/jcb.201601025
Autor:
David A. Shifrin, Meredith L. Weck, Scott W. Crawley, Matthew J. Tyska, Nathan E. Grega-Larson
Publikováno v:
Developmental Cell. 36(2):190-200
SummaryTransporting and sensory epithelial cells shape apical specializations using protocadherin-based adhesion. In the enterocyte brush border, protocadherin function requires a complex of cytoplasmic binding partners, although the composition of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106cc0319f1d630a847cd19191deb359
Publikováno v:
Molecular Biology of the Cell
Microvilli are actin-based protrusions that amplify plasma membrane area and mediate interactions with the extracellular environment. We found that the multifunctional actin regulator cordon bleu promotes the growth of intestinal brush border microvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515f0f11ecb89dd738f83b0d5ec1c0c6
https://doi.org/10.1091/mbc.e15-06-0443
https://doi.org/10.1091/mbc.e15-06-0443
Publikováno v:
Gut Microbes. 5:504-516
Enteropathogenic Escherichia coli (EPEC) induces dramatic remodeling of enterocyte brush borders, a process that includes microvillar effacement and actin pedestal formation. Although the Arp2/3 complex is involved in formation of a branched actin ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e60760b5262f0e556bf6c25e05817d
https://doi.org/10.4161/gmic.32084
https://doi.org/10.4161/gmic.32084
Publikováno v:
Cytoskeleton (Hoboken, N.J.). 73(11)
Cordon-bleu (COBL) is a multifunctional WASP-Homology 2 (WH2) domain-containing protein implicated in a wide variety of cellular functions ranging from dendritic arborization in neurons to the assembly of microvilli on the surface of transporting epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d04ef1a7752f6f924e7ab0a703619ed1
https://pubmed.ncbi.nlm.nih.gov/27464680
https://pubmed.ncbi.nlm.nih.gov/27464680
Publikováno v:
Current Biology. 28:2876-2888.e4
Transporting epithelial cells like those that line the gut build large arrays of actin-supported protrusions called microvilli, which extend from the apical surface into luminal spaces to increase functional surface area. Although critical for mainta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939a95c992a75aa7e510fd285915e418
https://doi.org/10.1016/j.cub.2018.07.022
https://doi.org/10.1016/j.cub.2018.07.022
Autor:
Hillary A. Hager, Elise R. Pfaltzgraff, Alissa M. Weaver, David M. Bader, H. Scott Baldwin, Nathan E. Grega-Larson, Xianghu Qu, Emily C. Benesh, Bong Hwan Sung, Paul M. Miller
Publikováno v:
Molecular Biology of the Cell
The Bves and NDRG4 proteins interact to regulate directional cell movement by mediating cell surface fusion of internalized fibronectin for resecretion. This provides the first evidence of Bves/NDRG4 protein function within subcellular trafficking pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb73b6b92a7ce0a79991303f4c2e9f63
https://pubmed.ncbi.nlm.nih.gov/24048452
https://pubmed.ncbi.nlm.nih.gov/24048452