Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Nathan Dyjack"'
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Autor:
Nathan D. Jackson, Nathan Dyjack, Elena Goleva, Lianghua Bin, Michael T. Montgomery, Cydney Rios, Jamie L. Everman, Patricia Taylor, Caroline Bronchick, Brittany N. Richers, Donald Y.M. Leung, Max A. Seibold
Publikováno v:
JID Innovations, Vol 4, Iss 4, Pp 100279- (2024)
A subgroup of patients with atopic dermatitis (AD) suffers from recurrent, disseminated herpes simplex virus skin infection, termed eczema herpeticum. To determine the transcriptional mechanisms of the skin and immune system pathobiology that underli
Externí odkaz:
https://doaj.org/article/5ac4c762010240c089e6706b050cde60
Autor:
Katherine C. Goldfarbmuren, Nathan D. Jackson, Satria P. Sajuthi, Nathan Dyjack, Katie S. Li, Cydney L. Rios, Elizabeth G. Plender, Michael T. Montgomery, Jamie L. Everman, Preston E. Bratcher, Eszter K. Vladar, Max A. Seibold
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Chronic lung diseases are characterized by molecular and cellular composition changes. Here the authors use single-cell RNA sequencing to map cell type-specific changes in human tracheal epithelium related to smoking, and to provide evidence for a tu
Externí odkaz:
https://doaj.org/article/9bcec16a7aeb4036b62487f931077a83
Autor:
Ivy K Brown, Nathan Dyjack, Mindy M Miller, Harsha Krovi, Cydney Rios, Rachel Woolaver, Laura Harmacek, Ting-Hui Tu, Brian P O'Connor, Thomas Danhorn, Brian Vestal, Laurent Gapin, Clemencia Pinilla, Max A Seibold, James Scott-Browne, Radleigh G Santos, R Lee Reinhardt
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009602 (2021)
The CD4+ T cell response is critical to host protection against helminth infection. How this response varies across different hosts and tissues remains an important gap in our understanding. Using IL-4-reporter mice to identify responding CD4+ T cell
Externí odkaz:
https://doaj.org/article/bfee9113d1934b3d8063baf5f57b2905
CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes
Autor:
Adam M. Sandor, Robin S. Lindsay, Nathan Dyjack, Jennifer C. Whitesell, Cydney Rios, Brenda J. Bradley, Kathryn Haskins, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Max A. Seibold, Jordan Jacobelli, Rachel S. Friedman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through th
Externí odkaz:
https://doaj.org/article/84f626d760c74ffda3d49e544096b774
A standard unsupervised analysis is to cluster observations into discrete groups using a dissimilarity measure, such as Euclidean distance. If there does not exist a ground-truth label for each observation necessary for external validity metrics, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6421ebf273245d0283702ff1e86e7c2
https://doi.org/10.1101/2022.02.03.479015
https://doi.org/10.1101/2022.02.03.479015
Publikováno v:
ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine
Single-cell RNA-sequencing (scRNA-seq) analyses typically begin by clustering a gene-by-cell expression matrix to empirically define groups of cells with similar expression profiles. We describe new methods and a new open source library, minicore, fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff424af2f8b0903fdda29b005d8b9be5
https://pubmed.ncbi.nlm.nih.gov/34778889
https://pubmed.ncbi.nlm.nih.gov/34778889
Publikováno v:
BCB
Single-cell RNA-sequencing (scRNA-seq) analyses typically begin by clustering a gene-by-cell expression matrix to empirically define groups of cells with similar expression profiles. We describe new methods and a new open source library, minicore, fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a69c9d645c33ab9113776f7e395604d
https://doi.org/10.1145/3459930.3469523
https://doi.org/10.1145/3459930.3469523
Autor:
Jennifer R. Knapp, Lidia Michalec, Anand Sripada, Max A. Seibold, Divya Verma, Dipa Sheth, Brian P. O'Connor, Kapil Sirohi, Rafeul Alam, Jerome T. McKay, Nathan Dyjack, Richard J. Martin, Mukesh Verma, Magdalena M. Gorska, Ting-Hui Tu
Publikováno v:
The Journal of Experimental Medicine
Verma et al. present an experimental approach for generation of ILC2 memory for allergic asthma. scRNA-seq and ATAC-seq identify a set of preparedness- and repression-inducing genes with memory formation. Their approach demonstrates a critical role f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f030e43030ae0ec722399736478c1993
https://doi.org/10.1084/jem.20201354
https://doi.org/10.1084/jem.20201354
Autor:
Thomas Danhorn, James P. Scott-Browne, Max A. Seibold, Rachel A. Woolaver, R. Lee Reinhardt, Harsha Krovi, Mindy M. Miller, Laurent Gapin, Brian Vestal, Clemencia Pinilla, Cydney Rios, Brian P. O'Connor, Nathan Dyjack, Ivy K Brown, Ting-Hui Tu, Laura Harmacek, Radleigh Santos
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009602 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009602 (2021)
The CD4+ T cell response is critical to host protection against helminth infection. How this response varies across different hosts and tissues remains an important gap in our understanding. Using IL-4-reporter mice to identify responding CD4+ T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965d2a8aa517c7889b852fbbf5ac5d18
http://europepmc.org/articles/PMC8216541
http://europepmc.org/articles/PMC8216541