Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca2+‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability

Autor: Yanan Zhao, Beibei Du, Praloy Chakraborty, Nathan Denham, Stéphane Massé, Patrick F.H. Lai, Mohammed Ali Azam, Filio Billia, Paaladinesh Thavendiranathan, Husam Abdel‐Qadir, Gary D. Lopaschuk, Kumaraswamy Nanthakumar

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)

Background We recently demonstrated that acute administration of ibrutinib, a Bruton's tyrosine kinase inhibitor used in chemotherapy for blood malignancies, increases ventricular arrhythmia (VA) vulnerability. A pathway of ibrutinib‐induced vulner

Externí odkaz: https://doaj.org/article/b2f674f7a00f4bfabfc90509645f8705

Supraventricular tachycardia following slow pathway ablation: What is the mechanism?

Autor: Nathan Denham, Kumaraswamy Nanthakumar

Publikováno v: Journal of Cardiovascular Electrophysiology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6937cf54c9bc55ef239235ea33d12c55
https://doi.org/10.1111/jce.15859

Complication rates following ventricular tachycardia ablation in ischaemic and non-ischaemic cardiomyopathies: a systematic review

Autor: Shui Hao Chin, Charles M. Pearman, Ahmed M. Adlan, Simon Modi, Derick Todd, Wern Yew Ding, Nathan Denham, Saagar Mahida, Laura J. Bonnett, Mark C.S. Hall

Publikováno v: Journal of Interventional Cardiac Electrophysiology
Ding, W Y, Pearman, C M, Bonnett, L, Adlan, A, Chin, S H, Denham, N, Modi, S, Todd, D M, Hall, M C S & Mahida, S 2021, ' Complication rates following ventricular tachycardia ablation in ischaemic and non-ischaemic cardiomyopathies : a systematic review ', Journal of interventional cardiac electrophysiology . https://doi.org/10.1007/s10840-021-00948-6

Background Catheter ablation of ventricular tachycardia (VT) is associated with potential major complications, including mortality. The risk of acute complications in patients with ischaemic cardiomyopathy (ICM) and non-ischaemic cardiomyopathy (NICM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52119efdaecdf558c63e82632e04dd30
https://doi.org/10.1007/s10840-021-00948-6

Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis

Autor: Katharine M. Dibb, George W.P. Madders, Andrew W. Trafford, Charlotte E.R. Smith, Nathan Denham, Charles M. Pearman

Publikováno v: Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Denham, N, Pearman, C, Madders, G, Smith, C E R, Trafford, A & Dibb, K 2021, ' Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis ', Frontiers in Physiology . https://doi.org/10.3389/fphys.2021.690897

BackgroundLarge animal models play an important role in our understanding of the pathophysiology of atrial fibrillation (AF). Our aim was to determine whether prospectively collected baseline variables could predict the development of sustained AF in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0768f2b78eb062ba547f19cf2a2d241
https://www.frontiersin.org/articles/10.3389/fphys.2021.690897/full

Systematic re-evaluation of SCN5A variants associated with Brugada syndrome

Autor: Simon Modi, Mark Hall, Charles M. Pearman, Richard Snowdon, Nathan Denham, Derick Todd, Wern Yew Ding, Robert M. Cooper, Saagar Mahida, Dhiraj Gupta, Johan E.P. Waktare

Publikováno v: Journal of Cardiovascular Electrophysiology. 30:118-127

Background A large number of SCN5A variants have been reported to underlie Brugada syndrome (BrS). However, the evidence supporting individual variants is highly heterogeneous. Objective We systematically re-evaluated all SCN5A variants reported in B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::966723224469e2887c7060e3557b4a01
https://doi.org/10.1111/jce.13740