Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nathan D. Hatch"'
Autor:
Nathan D. Hatch, Scot P. Ouellette
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Chlamydia trachomatis is a developmentally regulated, obligate intracellular bacterium that encodes three sigma factors: σ66, σ54, and σ28. σ66 is the major sigma factor controlling most transcription initiation during early- and mid-cyc
Externí odkaz:
https://doaj.org/article/da4e63aa765e40a1a3b8f10b95659b56
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Chlamydia trachomatis does not possess TrpL-mediated transcription attenuation of its trp operon. Here, the authors show that an iron-dependent regulator, YtgR, acts as a tryptophan-dependent attenuator of the trp operon in this organism, due to tran
Externí odkaz:
https://doaj.org/article/1d61775e0be44d8a805cabbaa95c91c5
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Chlamydia trachomatis and Streptococcus pyogenes are among the most prevalent bacterial pathogens of humans. Interestingly, both pathogens are tryptophan (Trp) auxotrophs and must acquire this essential amino acid from their environment. For
Externí odkaz:
https://doaj.org/article/79f105ed086a43e586063f1ee20ec55b
Publikováno v:
Infect Immun
The ability to inducibly repress gene expression is critical to the study of organisms, like Chlamydia, with reduced genomes in which the majority of genes are likely to be essential. We recently described the feasibility of a CRISPR interference (CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07b8854c4b1b3c9df5841fe31066f8a
https://doi.org/10.1128/iai.00108-21
https://doi.org/10.1128/iai.00108-21
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The trp operon of Chlamydia trachomatis is organized differently from other model bacteria. It contains trpR, an intergenic region (IGR), and the biosynthetic trpB and trpA open-reading frames. TrpR is a tryptophan-dependent repressor that regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458b1fd338c5b6acd5eb8ffa818cb3f4
https://doi.org/10.1038/s41467-020-20181-5
https://doi.org/10.1038/s41467-020-20181-5
The trp operon of Chlamydia trachomatis has a genetic organization that is distinct from other model bacteria. The operon contains the trpR open-reading frame (ORF), an intergenic region (IGR), and the trpB and trpA ORFs. TrpR mediates tryptophan-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df841bbbf4fb43ad75d8fd642f363a5c
Autor:
Nathan D. Hatch, Scot P. Ouellette
Publikováno v:
Infection and Immunity. 88
Chlamydia trachomatisis the leading cause of bacterial sexually transmitted infections, andC. pneumoniaecauses community-acquired respiratory infections.In vivo, the host immune system will release interferon-gamma (IFNγ) to combat infection. IFNγ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60e06eabbcc786d834e7aa1275a6bdf
https://doi.org/10.1128/iai.00943-19
https://doi.org/10.1128/iai.00943-19
Autor:
Nathan D, Hatch, Scot P, Ouellette
Publikováno v:
Infect Immun
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections, and Chlamydia pneumoniae causes community-acquired respiratory infections. In vivo, the host immune system will release gamma interferon (IFN-γ) to combat infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63e873b0b76f662b41a1bfedb46b0d8c
https://pubmed.ncbi.nlm.nih.gov/31964747
https://pubmed.ncbi.nlm.nih.gov/31964747
Autor:
Matthew J. Kling, Nagendra K. Chaturvedi, Garrett L. Sutton, Shantaram S. Joshi, Julie M. Vose, Nathan D. Hatch
Publikováno v:
Leukemialymphoma. 60(5)
Mantle cell lymphoma (MCL) represents an aggressive B-cell lymphoma with frequent relapse and poor survival. Recently, dysregulated histone-deacetylases (HDACs) and cell cycle CDK-Rb pathway have been shown to be commonly associated with MCL pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d3c3f2c9a29ffe3106a5712257f30d
https://pubmed.ncbi.nlm.nih.gov/30424705
https://pubmed.ncbi.nlm.nih.gov/30424705
Autor:
Julie M. Vose, Shantaram S. Joshi, Matthew J. Kling, Nagendra K. Chaturvedi, Garrett L. Sutton, Nathan D. Hatch
Publikováno v:
Cancer Research. 77:4051-4051
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma accounting for about 7% of all non-Hodgkins lymphoma. While multiple therapy regimens are available to treat MCL patients, ultimately relapse from therapy-resistant MCL, making MCL carry the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9b8ebed182e8604b2a64446729aa28a
https://doi.org/10.1158/1538-7445.am2017-4051
https://doi.org/10.1158/1538-7445.am2017-4051