Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Nathan D Elrod"'
Autor:
Lauren G. Mascibroda, Mohammad Shboul, Nathan D. Elrod, Laurence Colleaux, Hanan Hamamy, Kai-Lieh Huang, Natoya Peart, Moirangthem Kiran Singh, Hane Lee, Barry Merriman, Jeanne N. Jodoin, Poojitha Sitaram, Laura A. Lee, Raja Fathalla, Baeth Al-Rawashdeh, Osama Ababneh, Mohammad El-Khateeb, Nathalie Escande-Beillard, Stanley F. Nelson, Yixuan Wu, Liang Tong, Linda J. Kenney, Sudipto Roy, William K. Russell, Jeanne Amiel, Bruno Reversade, Eric J. Wagner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The integrator complex is required for the synthesis of protein coding and non-coding RNA and contains the protein INTS13. Here, the authors find germline mutations in INTS13 in two families with oral facial digital syndrome and show that the mutatio
Externí odkaz:
https://doaj.org/article/35883c108c1d4e72ba468a3fd1444767
Autor:
Min-Han Lin, Madeline K. Jensen, Nathan D. Elrod, Kai-Lieh Huang, Kevin A. Welle, Eric J. Wagner, Liang Tong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Integrator is a multi-subunit protein complex with roles in noncoding RNA 3′-end processing and mRNA transcription attenuation. Here, the authors reveal a conserved binding site for IP6 in the Integrator cleavage module and show that IP6 binding is
Externí odkaz:
https://doaj.org/article/0ee6e6961b0d4fdaad96646285719378
Autor:
Cory Wilson, Tinne C.J. Mertens, Pooja Shivshankar, Weizen Bi, Scott D. Collum, Nancy Wareing, Junsuk Ko, Tingting Weng, Ram P. Naikawadi, Paul J. Wolters, Pascal Maire, Soma S.K. Jyothula, Rajarajan A. Thandavarayan, Dewei Ren, Nathan D. Elrod, Eric J. Wagner, Howard J. Huang, Burton F. Dickey, Heide L. Ford, Harry Karmouty-Quintana
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. The role of the developmental transcription factor Sine oculis homeobox homolog 1 (SIX1) in the pathophysiology of lung fibrosis is not known. IPF lung tissue samp
Externí odkaz:
https://doaj.org/article/0b6befeecf974b68b90fc8fc86c89505
Autor:
Jun Cao, Sunil K. Verma, Elizabeth Jaworski, Stephanie Mohan, Chloe K. Nagasawa, Kempaiah Rayavara, Amanda Sooter, Sierra N. Miller, Richard J. Holcomb, Mason J. Powell, Ping Ji, Nathan D. Elrod, Eda Yildirim, Eric J. Wagner, Vsevolod Popov, Nisha J. Garg, Andrew L. Routh, Muge N. Kuyumcu-Martinez
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109910- (2021)
Summary: RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing that can influence gene expression in muscle cells, contributing to heart
Externí odkaz:
https://doaj.org/article/1c3849ba190a44869afb25b4370a9f1a
Autor:
Nicola de Prisco, Caitlin Ford, Nathan D. Elrod, Winston Lee, Lauren C. Tang, Kai-Lieh Huang, Ai Lin, Ping Ji, Venkata S. Jonnakuti, Lia Boyle, Maximilian Cabaj, Salvatore Botta, Katrin Õunap, Karit Reinson, Monica H. Wojcik, Jill A. Rosenfeld, Weimin Bi, Kristian Tveten, Trine Prescott, Thorsten Gerstner, Audrey Schroeder, Chin-To Fong, Jaya K. George-Abraham, Catherine A. Buchanan, Andrea Hanson-Khan, Jonathan A. Bernstein, Aikaterini A. Nella, Wendy K. Chung, Vicky Brandt, Marko Jovanovic, Kimara L. Targoff, Hari Krishna Yalamanchili, Eric J. Wagner, Vincenzo A. Gennarino
Publikováno v:
Science Advances. 9
Alternative polyadenylation (APA) creates distinct transcripts from the same gene by cleaving the pre-mRNA at poly(A) sites that can lie within the 3′ untranslated region (3′UTR), introns, or exons. Most studies focus on APA within the 3′UTR; h
Autor:
Enkhtuya Radnaa, Rheanna Urrabaz-Garza, Nathan D Elrod, Mariana de Castro Silva, Richard Pyles, Arum Han, Ramkumar Menon
Publikováno v:
Biol Reprod
Human fetal membrane and maternal decidua parietalis form one of the major feto-maternal interfaces during pregnancy. Studies on this feto-maternal interface is limited as several investigators have limited access to the placenta, and experience diff
Autor:
Muge N. Kuyumcu-Martinez, Vsevolod L. Popov, Chloe K. Nagasawa, Eric J. Wagner, Mason J. Powell, Nisha Jain Garg, Kempaiah Rayavara, Sunil Kumar Verma, Ping Ji, Stephanie Mohan, Nathan D. Elrod, Jun Cao, Elizabeth Jaworski, Andrew Routh, Amanda Sooter, Richard J. Holcomb, Eda Yildirim, Sierra N. Miller
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109910-(2021)
Cell reports
Cell reports
SUMMARY RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing that can influence gene expression in muscle cells, contributing to heart
Integrator has critical roles in noncoding RNA 3′-end processing as well as transcription attenuation of selected mRNAs. IntS11 is the endonuclease for RNA cleavage, as a part of the IntS4-IntS9-IntS11 complex (Integrator cleavage module, ICM). Our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481433b9819e3d729d9eca25411df433
https://doi.org/10.1101/2021.09.14.460315
https://doi.org/10.1101/2021.09.14.460315
Autor:
Hari Krishna, Yalamanchili, Nathan D, Elrod, Madeline K, Jensen, Ping, Ji, Ai, Lin, Eric J, Wagner, Zhandong, Liu
Publikováno v:
Methods in enzymology. 655
An increasing number of investigations have established alternative polyadenylation (APA) as a key mechanism of gene regulation through altering the length of 3' untranslated region (UTR) and generating distinct mRNA termini. Further, appreciation fo
Autor:
Madeline K, Jensen, Nathan D, Elrod, Hari Krishna, Yalamanchili, Ping, Ji, Ai, Lin, Zhandong, Liu, Eric J, Wagner
Publikováno v:
Methods in enzymology. 655
Over the past 15 years, investigations into alternative polyadenylation (APA) and its function in cellular physiology and pathology have greatly expanded due to the emergent appreciation of its key role in driving transcriptomic diversity. This growt