Parkinson’s disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical neurons

Autor: Joseph Kochmanski, Nathan C. Kuhn, Alison I. Bernstein

Publikováno v: npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-13 (2022)

Abstract Evidence for epigenetic regulation playing a role in Parkinson’s disease (PD) is growing, particularly for DNA methylation. Approximately 90% of PD cases are due to a complex interaction between age, genes, and environmental factors, and e

Externí odkaz: https://doaj.org/article/4cdfcdf39e54442ab2a0599f220e9af5

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Autor: Aysegul O. Gezer, Joseph Kochmanski, Sarah E. VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, Kathryn M. Miller, Nathan C. Kuhn, Danielle E. Herman, Alyssa McIntire, Jack W. Lipton, Kelvin C. Luk, Sheila M. Fleming, Caryl E. Sortwell, Alison I. Bernstein

Publikováno v: Neurobiology of Disease, Vol 141, Iss , Pp 104947- (2020)

Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed that developmental dieldrin exposure increased neuronal susceptibility to M

Externí odkaz: https://doaj.org/article/212f253653d444c5bfd9ea221a1eac9e

Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

Autor: Markus Britschgi, Viviane Labrie, Irving E. Vega, Lee Marshall, Nazia Maroof, Juliane Siebourg-Polster, Nathan C. Kuhn, Peipei Li, Wei Cui, Juozas Gordevičius, Jared Lamp, Sean Lang, Fredric P. Manfredsson, Roberta Lauria, Christina Rueb, Elizabeth Ensink, Bryan A. Killinger, Pierre Maliver

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature communications, Berlin : Nature research, 2021, vol. 12, iss. 1, art. no. 5134, p. [1-18]

The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption of the autophagy-lysosome pathway (ALP) may contribute to α-synuclein aggregation. Here we examined epigenetic alterat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d44d5911b4734a08153ebb3092b95e
https://doaj.org/article/f9f6d09087434442861f49df6420270e

Parkinson's disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical neurons

Autor: Joseph, Kochmanski, Nathan C, Kuhn, Alison I, Bernstein

Publikováno v: NPJ Parkinson's disease. 8(1)

Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing, particularly for DNA methylation. Approximately 90% of PD cases are due to a complex interaction between age, genes, and environmental factors, and epigenetic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a4f30292c02b7958c19ba3aad34f3bd
https://pubmed.ncbi.nlm.nih.gov/36151217

Basic Concepts in Viral Vector-Mediated Gene Therapy

Autor: Rhyomi C. Sellnow, Matthew J. Benskey, Roslyn Vashon, Kathryn M. Miller, Ivette M. Sandoval, Nathan C. Kuhn, Aysegul O. Gezer, Fredric P. Manfredsson

Publikováno v: Methods in Molecular Biology ISBN: 9781493990641

Today any researcher with the desire can easily purchase a viral vector. However, despite the availability of viral vectors themselves, the requisite knowledge that is absolutely essential to conducting a gene therapy experiment remains somewhat obsc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b22acb18d55073656a0fcd6527ecaeb
https://doi.org/10.1007/978-1-4939-9065-8_1