Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nathan C. Klapoetke"'
Autor:
Nathan C. Klapoetke, Aljoscha Nern, Edward M. Rogers, Gerald M. Rubin, Michael B. Reiser, Gwyneth M. Card
Publikováno v:
Neuron. 110(10)
Topographic maps, the systematic spatial ordering of neurons by response tuning, are common across species. In Drosophila, the lobula columnar (LC) neuron types project from the optic lobe to the central brain, where each forms a glomerulus in a dist
Autor:
Aimei Yang, Yong Ku Cho, Nathan C. Klapoetke, Demian Park, Edward S. Boyden, Amy S. Chuong, Fei Chen
Publikováno v:
Journal of Biological Chemistry. 294:3806-3821
Channelrhodopsins (ChRs) are light-gated ion channels in widespread use in neuroscience for mediating the genetically targetable optical control of neurons (optogenetics). ChRs pass multiple kinds of ions, and although nonspecific ChR-mediated conduc
Autor:
Xue eHan, Brian Y Chow, Huihui eZhou, Nathan C Klapoetke, Amy eChuong, Reza eRajimehr, Aimei eYang, Michael V Baratta, Jonathan eWinkle, Robert eDesimone, Edward S Boyden
Publikováno v:
Frontiers in Systems Neuroscience, Vol 5 (2011)
Technologies for silencing the electrical activity of genetically-targeted neurons in the brain are important for assessing the contribution of specific cell types and pathways towards behaviors and pathologies. Recently we found that archaerhodopsin
Externí odkaz:
https://doaj.org/article/cb928562f61f49cc819b7f7a5e1ce68b
Autor:
Michael B. Reiser, Patrick Breads, Martin Y. Peek, Gerald M. Rubin, Edward M. Rogers, Gwyneth M Card, Aljoscha Nern, Nathan C. Klapoetke
Publikováno v:
Nature. 551(7679)
Nervous systems combine lower-level sensory signals to detect higher-order stimulus features critical to survival, such as the visual looming motion created by an imminent collision or approaching predator. Looming-sensitive neurons have been identif
Autor:
Venkatesh N. Murthy, D. Jed Harrison, Adam E. Cohen, Yongxin Zhao, Gabriella L. Boulting, Edward S. Boyden, Dougal Maclaurin, Robert E. Campbell, Peng Zou, Daniel Hochbaum, Jessica L. Saulnier, Samouil L. Farhi, Bernardo L. Sabatini, Christoph Straub, Joel M. Kralj, Niklas Smedemark-Margulies, Nathan C. Klapoetke, Gane Ka-Shu Wong, Christopher A. Werley, Michael Melkonian, Vikrant Kapoor, Yong Ku Cho
Publikováno v:
Nature methods
PMC
PMC
All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, QuasAr1 and 2, which s
Autor:
Henninger Michael, Jessica A. Cardin, Volker Busskamp, Mitra L Miri, Gillian A. Matthews, Masaaki Ogawa, Rachel C. Bandler, Amy S. Chuong, Craig R. Forest, Brian Y. Chow, Andreas T. Sørensen, Edward S. Boyden, Botond Roska, Xue Han, Yingxi Lin, Kay M. Tye, Nathan C. Klapoetke, Brian D. Allen, Shreshtha B. Ramanlal, Suhasa B. Kodandaramaiah, Leah Acker, Andrew Young
Publikováno v:
Nature neuroscience
Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of their contributions to brain functions. Red light penetrates deeper into tissue than other visible wavelengths. We present a red-shifted cruxhalorhodopsin,
Autor:
Ariel Edward Hight, Barbara G. Shinn-Cunningham, Edward S. Boyden, Daniel B. Polley, Jenny X. Chen, Kenneth E. Hancock, Nathan C. Klapoetke, Daniel J. Lee, Wei Guo
Publikováno v:
Nature Publishing Group
Scientific Reports
Scientific Reports
Optogenetics provides a means to dissect the organization and function of neural circuits. Optogenetics also offers the translational promise of restoring sensation, enabling movement or supplanting abnormal activity patterns in pathological brain ci
Autor:
Alexander van der Bourg, Maya Mills, Amy S. Chuong, Adrian Cheng, Andrea Benucci, Atsushi Miyawaki, Ladan Egolf, Matteo Carandini, Nathan C. Klapoetke, Fritjof Helmchen, Bosiljka Tasic, Edward S. Boyden, Susan M. Sunkin, Lu Li, R. Clay Reid, Yusuke Niino, Andras Nagy, Claudio Monetti, Ruth M. Empson, Hong Gu, Linda Madisen, Thomas Knöpfel, Thuc Nghi Nguyen, Aleena R. Garner, Hongkui Zeng, Daisuke Shimaoka
Publikováno v:
PMC
ResearcherID
ResearcherID
available in PMC 2016 March 04
An increasingly powerful approach for studying brain circuits relies on targeting genetically encoded sensors and effectors to specific cell types. However, current approaches for this are still limited in function
An increasingly powerful approach for studying brain circuits relies on targeting genetically encoded sensors and effectors to specific cell types. However, current approaches for this are still limited in function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448b9c6d15e8ef9fbb38bfab62ad8117
https://doi.org/10.5167/uzh-117185
https://doi.org/10.5167/uzh-117185
Autor:
Amy S. Chuong, Barbara Surek, Brian Y. Chow, Jun Wang, Amanda Birdsey-Benson, Stefan R. Pulver, Vivek Jayaraman, Zhijian Tian, Yinlong Xie, Yong Ku Cho, Nathan C. Klapoetke, Gane Ka-Shu Wong, Eric J. Carpenter, Michael Melkonian, Zhixiang Yan, Yong Zhang, Sung Soo Kim, Tania K. Morimoto, Martha Constantine-Paton, Yasunobu Murata, Edward S. Boyden
Publikováno v:
Nature methods
Optogenetic tools enable examination of how specific cell types contribute to brain circuit functions. A long-standing question is whether it is possible to independently activate two distinct neural populations in mammalian brain tissue. Such a capa
Publikováno v:
Methods in enzymology. 497
The life and operation of cells involve many physiological processes that take place over fast timescales of milliseconds to minutes. Genetically-encoded technologies for driving or suppressing specific fast physiological processes in intact cells, p