Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nathan C. Bingham"'
Publikováno v:
Molecular Medicine, Vol 24, Iss 1, Pp 1-10 (2018)
Abstract Background Exposure of rodents to chronic high-fat diet (HFD) results in upregulation of inflammatory markers and proliferation of microglia within the mediobasal hypothalamus. Such hypothalamic inflammation is associated with metabolic dysf
Externí odkaz:
https://doaj.org/article/59a5caca5c1e4205b6256e09fc99b74f
Autor:
Elly Brokamp, Ashley H. Shoemaker, Nathan C. Bingham, Laura Fairbrother, Ann O. Scheimann, Jennifer L. Miller, Althea Robinson Shelton, Jessica Duis, Parisa Salehi, Anna Childers, Pieter Joost van Wattum
Publikováno v:
Molecular Genetics & Genomic Medicine
Background Prader–Willi syndrome (PWS) is a complex neuroendocrine disorder affecting approximately 1/15,000–1/30,000 people. Unmet medical needs of individuals with PWS make it a rare disease that models the importance of multidisciplinary appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b18cedbf1bc0e229fa23b1da67c245
https://pubmed.ncbi.nlm.nih.gov/30697974
https://pubmed.ncbi.nlm.nih.gov/30697974
Autor:
Todd M. Jenkins, Nathan C. Bingham, Thomas H. Inge, Susan R. Rose, Jennifer Black, Vincent E. Horne
Publikováno v:
Obesity (Silver Spring, Md.). 26(11)
Objective Hypothalamic obesity (HyOb) is a rare cause of rapid weight gain and early metabolic comorbidities. Effective treatment strategies are limited. The registry collected participant data and compared treatment approaches. Methods The Internati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b50dc0ecb56c76f8f2e7a2e89756549
https://pubmed.ncbi.nlm.nih.gov/30296362
https://pubmed.ncbi.nlm.nih.gov/30296362
Autor:
Nathan C. Bingham, Javier E. Stern, Anneke Alkemade, Jessica A. Filosa, Andries Kalsbeek, Paul T. Pfluger, Martin Gericke, Chun-Xia Yi, Martin Krüger, Ingo Bechmann, Matthias H. Tschöp, James P. Herman, Stephen C. Woods, Richard A. Lang, Marcus Baumann, Sophie Hanske, Dhiraj G. Kabra
Publikováno v:
Mol. Metab. 1, 95-100 (2012)
Molecular metabolism, 1(1-2), 95-100. Elsevier GmbH
Molecular Metabolism, 1, 95-100. Elsevier B.V.
Molecular metabolism, 1(1-2), 95-100. Elsevier GmbH
Molecular Metabolism, 1, 95-100. Elsevier B.V.
Obesity, type 2 diabetes, and related diseases represent major health threats to modem society. Related pathophysiology of impaired neuronal function in hypothalamic control centers regulating metabolism and body weight has been dissected extensively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd74ecd33900c8c83099c9ca56e7e636
https://doi.org/10.1016/j.molmet.2012.08.004
https://doi.org/10.1016/j.molmet.2012.08.004
Publikováno v:
Human Molecular Genetics. 18:405-417
Sexually dimorphic development of the gonads is controlled by positive and negative regulators produced by somatic cells. Many Wnt ligands, including ones that signal via the canonical beta-catenin pathway, are expressed in fetal gonads. beta-catenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44320f54707697214f823dd82740af44
https://doi.org/10.1093/hmg/ddn362
https://doi.org/10.1093/hmg/ddn362
Publikováno v:
Endocrinology. 149:2138-2148
Leptin, an adipocyte-derived hormone, has emerged as a critical regulator of energy homeostasis. The leptin receptor (Lepr) is expressed in discrete regions of the brain; among the sites of highest expression are several mediobasal hypothalamic nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223534b1a7cebcafd9de424c4892d73b
https://doi.org/10.1210/en.2007-1200
https://doi.org/10.1210/en.2007-1200
Publikováno v:
European Journal of Endocrinology. 157:233-238
Objective: Steroidogenic factor 1 (SF1), officially designated NR5A1, is a nuclear receptor that plays key roles in endocrine development and function. Previous reports of human SF1 mutations revealed a spectrum of phenotypes affecting adrenal functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9e0519a7d79648d9d274e810dcd59f
https://doi.org/10.1530/eje-07-0113
https://doi.org/10.1530/eje-07-0113
Publikováno v:
genesis. 44:419-424
The Cre-loxP strategy provides an approach to disrupt genes in specific tissues and/or cell types, circumventing lethality associated with global knockouts or secondary effects due to gene inactivation at other sites. A critical component is the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b637ae62c19eca96441bfa826aa3c3e8
https://doi.org/10.1002/dvg.20231
https://doi.org/10.1002/dvg.20231
Autor:
H. Eric Xu, Kelly Suino, Amanda Kovach, Steven A. Kliewer, Nathan C. Bingham, Jennifer Daugherty, Yong Li, Mihwa Choi, Greg Cavey
Publikováno v:
Molecular Cell. 17(4):491-502
The orphan nuclear receptor steroidogenic factor 1 (SF-1) regulates the differentiation and function of endocrine glands. Although SF-1 is constitutively active in cell-based assays, it is not known whether this transcriptional activity is modulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab490638e93b3dd4b5a0e6f497c53b4
Autor:
William E. Rainey, Nathan C. Bingham, Ana Elisa C. Billerbeck, Berenice B. Mendonca, Keith L. Parker, Sorahia Domenice, Rafaela Vieira Correa
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:1767-1772
Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor that plays key roles in endocrine development and function. Knockout mice lacking SF-1 have adrenal and gonadal agenesis, impaired gonadotropin expression, and structural abnormalities of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3f205b62c56f93422eccd680feb6e1
https://doi.org/10.1210/jc.2003-031240
https://doi.org/10.1210/jc.2003-031240