Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Nathan C Winn"'
Autor:
Nathan C Winn, Zachary I Grunewald, Ying Liu, Timothy D Heden, Lauren M Nyhoff, Jill A Kanaley
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170690 (2017)
BACKGROUND AND PURPOSE:Irisin is an exercise-responsive myokine that has been proposed to exert anti-obesity benefits; yet its response during exercise in obese women is not described. This study characterized plasma irisin levels during a single bou
Externí odkaz:
https://doaj.org/article/cb3d7cdf1c624d89bdaef62c3ef7a416
Autor:
Nathan C. Winn, Michael W. Schleh, Jamie N. Garcia, Louise Lantier, Owen P. McGuinness, Joslin A. Blair, Alyssa H. Hasty, David H. Wasserman
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101901- (2024)
Mammals are protected from changes in environmental temperature by altering energetic processes that modify heat production. Insulin is the dominant stimulus of glucose uptake and metabolism, which are fundamental for thermogenic processes. The purpo
Externí odkaz:
https://doaj.org/article/2f51ca3484694f5b8883840b5ba0654e
Autor:
Neil T. Sprenkle, Nathan C. Winn, Kaitlyn E. Bunn, Yang Zhao, Deborah J. Park, Brenna G. Giese, John J. Karijolich, K. Mark Ansel, C. Henrique Serezani, Alyssa H. Hasty, Heather H. Pua
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112928- (2023)
Summary: Identifying molecular circuits that control adipose tissue macrophage (ATM) function is necessary to understand how ATMs contribute to tissue homeostasis and obesity-induced insulin resistance. In this study, we find that mice with a myeloid
Externí odkaz:
https://doaj.org/article/818abb9941584f42ae9b426fc3080508
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Adipose immune cells contribute to obesity-related disease, but less is known about weight cycling. Here, authors show that weight loss reduces diabetes risk, but inflammatory adipose immune cell populations persist and may contribute to worsened dia
Externí odkaz:
https://doaj.org/article/adec12737944444d9b747a7e1e9dd050
Autor:
Rebecca K. Dirkes, Nathan C. Winn, Thomas J. Jurrissen, Dennis B. Lubahn, Victoria J. Vieira-Potter, Jaume Padilla, Pamela S. Hinton
Publikováno v:
FACETS, Vol 5, Pp 328-348 (2020)
Estrogen receptor-α knockout (ERKO) in female rodents results in bone loss associated with increased osteocyte sclerostin expression; whether this also occurs in males is unknown. Here, we examined the effects of ERKO on femoral cortical geometry, t
Externí odkaz:
https://doaj.org/article/18f707a56b924fa9b9c2a145b02258df
Autor:
Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Nathan C. Winn, Jaume Padilla, Marc Liesa, Harold S. Sacks, Orian S. Shirihai
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102087- (2021)
Beige adipocyte mitochondria contribute to thermogenesis by uncoupling and by ATP-consuming futile cycles. Since uncoupling may inhibit ATP synthesis, it is expected that expenditure through ATP synthesis is segregated to a disparate population of mi
Externí odkaz:
https://doaj.org/article/4b8e9dfe1be44446bb4a1b85629f27e1
Publikováno v:
The Journal of Physiology. 600:4485-4501
Triggering receptor expressed on myeloid cells 2 (Trem2) is highly expressed on myeloid cells and is involved in cellular lipid homeostasis and inflammatory processes. Trem2 deletion in mice (Trem2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682f54382729acdfa2144307ba803c33
https://doi.org/10.1113/jp283684
https://doi.org/10.1113/jp283684
Autor:
Nathan C. Winn, Matthew A. Cottam, Monica Bhanot, Heather L. Caslin, Jamie N. Garcia, Rafael Arrojo e Drigo, Alyssa H. Hasty
Publikováno v:
Diabetes. 71:2313-2330
In the setting of obesity and insulin resistance, glycemia is controlled in part by β-cell compensation and subsequent hyperinsulinemia. Weight loss improves glycemia and decreases hyperinsulinemia, whereas weight cycling worsens glycemic control. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05ed30036a11ed8f1f9131f4b4f5e16
https://doi.org/10.2337/db22-0161
https://doi.org/10.2337/db22-0161
Publikováno v:
Am J Physiol Endocrinol Metab
Tissue iron overload is associated with insulin resistance and mitochondrial dysfunction in rodents and humans; however, the mechanisms or cell types that mediate this phenotype are not completely understood. Macrophages (Mɸs) are known to contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8371afcfed30983d72490e1d328ec441
https://doi.org/10.1152/ajpendo.00116.2021
https://doi.org/10.1152/ajpendo.00116.2021
Autor:
Alyssa H. Hasty, Rafael Arrojo e Drigo, Jamie N. Garcia, Heather L. Caslin, Monica Bhanot, Matthew A. Cottam, Nathan C. Winn
In the setting of obesity and insulin resistance, glycemia is controlled in part by beta cell compensation and subsequent hyperinsulinemia. Weight loss improves glycemia and decreases hyperinsulinemia, whereas weight cycling worsens glycemic control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e3788ce8f6415090d921f0409bf7d4
https://doi.org/10.2337/figshare.20246628.v1
https://doi.org/10.2337/figshare.20246628.v1
