Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Nathan Brinkman"'
Autor:
Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Leonardo O. Reis, Nathan Brinkman, Arthur L. Burnett, Fernando Ferreira Costa, Fábio Henrique Silva
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the penile erection control mechanism and resulting in prolonged penile erec
Externí odkaz:
https://doaj.org/article/97a1aed1fb2640a7a30ac134e1540622
Autor:
Maria Feola, Andrea Zamperone, Daniel Moskop, Huiyong Chen, Carla Casu, Dechen Lama, Julie Di Martino, Mansour Djedaini, Luena Papa, Marc Ruiz Martinez, Tenzin Choesang, Jose Javier Bravo-Cordero, Matthew MacKay, Paul Zumbo, Nathan Brinkman, Charles S. Abrams, Stefano Rivella, Shilpa Hattangadi, Christopher E. Mason, Ronald Hoffman, Peng Ji, Antonia Follenzi, Yelena Z. Ginzburg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Maria Feola et al., elucidate the compensatory role of pleckstrin-2 in ineffective erythropoiesis in β-thalassemic mice by reducing cofilin-mediated apoptosis and enhancing enucleation by activating RacGTPases. These findings could support future th
Externí odkaz:
https://doaj.org/article/e6bba204b45a41b58086958c1edd4975
Autor:
Alex Adusei Agyemang, Suvi Vallius Kvist, Nathan Brinkman, Thomas Gentinetta, Miriam Illa, Niklas Ortenlöf, Bo Holmqvist, David Ley, Magnus Gram
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with deposition of redox active cell-free hemoglobin (Hb), derived from hemorrhagic cerebrospinal fluid (CSF), in the cerebrum and cerebellum. In a recent study, u
Externí odkaz:
https://doaj.org/article/82df9ef0f8c04fa597ace728d66fe69d
Autor:
Tian Lin, Jialin Liu, Feng Huang, Tjitske S R van Engelen, Sujatha R Thundivalappil, Frank E Riley, Michael Super, Alexander L Watters, Ann Smith, Nathan Brinkman, Donald E Ingber, H Shaw Warren
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 22-31 (2016)
Abstract Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to proteas
Externí odkaz:
https://doaj.org/article/d28aaa6444a64457a7d78b6782fbfc10
Autor:
Nicolas S. Merle, Anne Grunenwald, Marie-Lucile Figueres, Sophie Chauvet, Marie Daugan, Samantha Knockaert, Tania Robe-Rybkine, Remi Noe, Olivia May, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P. Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D. Dimitrov, Lubka T. Roumenina
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Intravascular erythrocyte destruction, accompanied by the release of pro-oxidative and pro-inflammatory components hemoglobin and heme, is a common event in the pathogenesis of numerous diseases with heterogeneous etiology and clinical features. A fr
Externí odkaz:
https://doaj.org/article/bb438c2a6781455db45860b5d624b879
Autor:
John D Belcher, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, Hao Nguyen, Phong Nguyen, Trevor Killeen, Sylvia M Miescher, Nathan Brinkman, Karl A Nath, Clifford J Steer, Gregory M Vercellotti
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196455 (2018)
During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states. Hapt
Externí odkaz:
https://doaj.org/article/37b25741c6b04581bd4abeec6a919507
Publikováno v:
Biotechnology Journal.
Publikováno v:
Rossi's Principles of Transfusion Medicine. :216-235
Autor:
Jonathan D. Knott, Michael S. Sabbah, Bradley R. Lewis, Abdalla Hassan, James D. Gladden, Malcolm R. Bell, David R. Holmes, Nathan Brinkman, Brent Konz, Mandeep Singh, Charanjit S. Rihal, Gregory W. Barsness, Abhiram Prasad, Gurpreet S. Sandhu, Rajiv Gulati, Yader Sandoval
Publikováno v:
Journal of the Society for Cardiovascular Angiography & Interventions. 2:100590
Autor:
Thomas Gentinetta, John D. Belcher, Valérie Brügger-Verdon, Jacqueline Adam, Tanja Ruthsatz, Joseph Bain, Daniel Schu, Lisa Ventrici, Monika Edler, Hadi Lioe, Kalpeshkumar Patel, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, Andreas Wassmer, Meena Jain, Marcel Mischnik, Matthias Pelzing, Kirstee Martin, Roslyn Davis, Svetlana Didichenko, Alexander Schaub, Nathan Brinkman, Eva Herzog, Adrian Zürcher, Gregory M. Vercellotti, Gregory J. Kato, Gerald Höbarth
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 630, p 630 (2022)
Journal of Clinical Medicine; Volume 11; Issue 3; Pages: 630
Journal of Clinical Medicine; Volume 11; Issue 3; Pages: 630
People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates inflammatory cell adhesio