Výsledky vyhledávání - "Nathan B. P. Adams"

Akademický článek

Transporter characterisation reveals aminoethylphosphonate mineralisation as a key step in the marine phosphorus redox cycle

Autor: Andrew R. J. Murphy, David J. Scanlan, Yin Chen, Nathan B. P. Adams, William A. Cadman, Andrew Bottrill, Gary Bending, John P. Hammond, Andrew Hitchcock, Elizabeth M. H. Wellington, Ian D. E. A. Lidbury

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Here the authors show that 2-aminoethylphosphonate (2AEP) mineralisation is widespread in the global ocean, operating independently of exogenous inorganic phosphate concentration. They propose 2AEP may be a major route for the regeneration of phospha

Externí odkaz: https://doaj.org/article/ee97040b023c4eed912fd25d3538fa4b

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Akademický článek

The molecular basis of phosphite and hypophosphite recognition by ABC-transporters

Autor: Claudine Bisson, Nathan B. P. Adams, Ben Stevenson, Amanda A. Brindley, Despo Polyviou, Thomas S. Bibby, Patrick J. Baker, C. Neil Hunter, Andrew Hitchcock

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Some bacteria can use inorganic phosphite and hypophosphite as sources of inorganic phosphorus. Here, the authors report crystal structures of the periplasmic proteins that bind these reduced phosphorus species and show that a P-H…π interaction be

Externí odkaz: https://doaj.org/article/fb628c898a23417e81de94e06a980504

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How the O2-dependent Mg-protoporphyrin monomethyl ester cyclase forms the fifth ring of chlorophylls

Autor: Mark J. Dickman, Guangyu E. Chen, Philip J. Jackson, Nathan B. P. Adams, C. Neil Hunter

Publikováno v: Nature plants
Nature Plants

Mg-protoporphyrin IX monomethyl ester (MgPME) cyclase catalyses the formation of the isocyclic ring, producing protochlorophyllide a and contributing substantially to the absorption properties of chlorophylls and bacteriochlorophylls. The O2-dependen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f964047fd3bdab07867bd442fe87ef7
http://europepmc.org/articles/PMC7610348

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The ChlD subunit links the motor and porphyrin binding subunits of magnesium chelatase

Autor: Nathan B. P. Adams, Andrew Hitchcock, Bethany Johnson, Amanda A. Brindley, Mark J. Dickman, Philip J. Jackson, David A. Farmer, James D. Reid, C. Neil Hunter

Publikováno v: Biochemical Journal

Magnesium chelatase initiates chlorophyll biosynthesis, catalysing the MgATP2−-dependent insertion of a Mg2+ ion into protoporphyrin IX. The catalytic core of this large enzyme complex consists of three subunits: Bch/ChlI, Bch/ChlD and Bch/ChlH (in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26637e1cbe808bbe1bd159bc33facc6f
https://doi.org/10.1042/bcj20190095

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Quantifying the Interaction of Phosphite with ABC Transporters: MicroScale Thermophoresis and a Novel His-Tag Labeling Approach

Autor: Tanja, Bartoschik, Amit, Gupta, Beate, Kern, Andrew, Hitchcock, Nathan B P, Adams, Nuska, Tschammer

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2168

The combination of MicroScale Thermophoresis (MST) and near-native site-specific His-tag labeling enables simple, robust, and reliable determination of the binding affinity between proteins and ligands. To demonstrate its applicability for periplasmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7816c13bf19fc21a4b8d8babb85592ba
https://pubmed.ncbi.nlm.nih.gov/33582986

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The active site of magnesium chelatase

Autor: Nathan B P, Adams, Claudine, Bisson, Amanda A, Brindley, David A, Farmer, Paul A, Davison, James D, Reid, C Neil, Hunter

Publikováno v: Nature plants. 6(12)

The insertion of magnesium into protoporphyrin initiates the biosynthesis of chlorophyll, the pigment that underpins photosynthesis. This reaction, catalysed by the magnesium chelatase complex, couples ATP hydrolysis by a ChlID motor complex to chela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8648c028516e72d25c1ff8ff34fd06c0
https://pubmed.ncbi.nlm.nih.gov/33257858

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Quantifying the Interaction of Phosphite with ABC Transporters: MicroScale Thermophoresis and a Novel His-Tag Labeling Approach

Autor: Beate Kern, Nathan B. P. Adams, Andrew Hitchcock, Amit J. Gupta, Nuska Tschammer, Tanja Bartoschik

Publikováno v: Methods in Molecular Biology ISBN: 9781071607237

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bbe5b67218f3d03c105f325742e7507
https://doi.org/10.1007/978-1-0716-0724-4_2

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Phosphite binding by the HtxB periplasmic binding protein depends on the protonation state of the ligand

Autor: Angus J. Robertson, Nathan B. P. Adams, Claudine Bisson, Andrew Hitchcock, C. Neil Hunter

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

Phosphorus acquisition is critical for life. In low phosphate conditions, some species of bacteria have evolved mechanisms to import reduced phosphorus compounds, such as phosphite and hypophosphite, as alternative phosphorus sources. Uptake is facil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6b57c8087fd820226e05aec206819e
http://europepmc.org/articles/PMC6629693

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Nanomechanical and Thermophoretic Analyses of the Nucleotide-Dependent Interactions between the AAA+ Subunits of Magnesium Chelatase

Autor: Cvetelin Vasilev, Amanda A. Brindley, Nathan B. P. Adams, C. Neil Hunter

Publikováno v: Journal of the American Chemical Society

In chlorophyll biosynthesis, the magnesium chelatase enzyme complex catalyzes the insertion of a Mg(2+) ion into protoporphyrin IX. Prior to this event, two of the three subunits, the AAA(+) proteins ChlI and ChlD, form a ChlID-MgATP complex. We used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07149a11d22857897a8e56134d3b3de0
https://doi.org/10.1021/jacs.6b02827

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Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo –designed heme protein

Autor: George A. Sutherland, Andrew Hitchcock, Nathan B. P. Adams, C. Neil Hunter, Fabio Sterpone, Pierre Tufféry, Katie J. Grayson, Dirk B. Auman, Daphne M.J. Mermans, P. Leslie Dutton, Angus J. Robertson, Alexander S. Jones, Colin Robinson, Amanda A. Brindley, Philippe Derreumaux

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (18), pp.6672-6681. ⟨10.1074/jbc.RA117.000880⟩
The Journal of Biological Chemistry

Protein transport across the cytoplasmic membrane of bacterial cells is mediated by either the general secretion (Sec) system or the twin-arginine translocase (Tat). The Tat machinery exports folded and cofactor-containing proteins from the cytoplasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d47a2941212908a5e7afb119168d42
https://hal.archives-ouvertes.fr/hal-02360042

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