Výsledky vyhledávání - "Nathan B. Mantlo"

Akademický článek

Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure

Autor: Guoqing Cao, Thomas P. Beyer, Youyan Zhang, Robert J. Schmidt, Yan Q. Chen, Sandra L. Cockerham, Karen M. Zimmerman, Sotirios K. Karathanasis, Ellen A. Cannady, Todd Fields, Nathan B. Mantlo

Publikováno v: Journal of Lipid Research, Vol 52, Iss 12, Pp 2169-2176 (2011)

Cholesteryl ester transfer protein (CETP) catalyses the exchange of cholesteryl ester and triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in modulating plasma HDL cholesterol levels in humans is well established a

Externí odkaz: https://doaj.org/article/814d7db5161b4c7e8b11650ddcf3aa93

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In vivo pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for angiotensin AT2 receptors

Autor: Theodore P. Broten, William J. Greenlee, Robert A. Gabel, Nathan B. Mantlo, Peter K. S. Siegl, Debra Ondeyka, Salah D. Kivlighn, Raymond S.L. Chang, Gloria J. Zingaro, Raymond E. Gibson

Publikováno v: European Journal of Pharmacology. 294:439-450

L-163,017 (6-[benzoylamino]-7-methyl-2-propyl-3-[(2′-(N-(3-methyl-1-butoxy)carbonylaminosulfonyl)[1,1′]-biphenyl-4-yl]-methyl]-3H-imidazo-[4,5-b] is a potent, orally active, nonpeptide angiotensin II receptor antagonist. Conscious rats and dogs w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bee47301c887cc474cb3e85ad342b77
https://doi.org/10.1016/0014-2999(95)00564-1

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Acidic phenols: a new class of potent nonpeptide angiotensin II receptor antagonists

Autor: W.J. Greenlee, Dorothy Levorse, Kenneth J. Fitch, Jim Tata, Peter K. S. Siegl, R. S. L. Chang, Karen Owens, Dooseop Kim, Tsing-Bau Chen, Gloria J. Zingaro, S. Scheck, Daljit S. Dhanoa, Nathan B. Mantlo, Salah D. Kivlighn

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:207-212

A series of imidazo[4,5-b]pyridine-based acidic phenols (Table 1,2) and biphenyl ethers (Table 3) are exemplified as novel non-peptide AII receptor antagonists. 0,0′-substituents which affect the acidity of the phenolic portion dramatically impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b4edd3df3b4f383961e4375095d9fa8
https://doi.org/10.1016/s0960-894x(01)81148-3

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Evaluation of heterocyclic acid equivalents as tetrazole replacements in imidazopyridine-based nonpeptide angiotensin II receptor antagonists

Autor: Salah D. Kivlighn, R. S. L. Chang, Dooseop Kim, Nathan B. Mantlo, W.J. Greenlee

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:41-44

A series of imidazol[4,5-b] pyridine AII antagonists incorporating heterocyclic acid equivalents, e.g., oxathiadiazoles, thiatriazoles, and dioxobenzothiadiazines, are exemplified as novel non-peptide AII receptor antagonists. The most potent antagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaa12ccad1144f10b09e820348556f5e
https://doi.org/10.1016/s0960-894x(01)81119-7

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ChemInform Abstract: Imidazo(4,5-b)pyridine-Based AT1/AT2 Angiotensin II Receptor Antagonists

Autor: Debra Ondeyka, Nathan B. Mantlo, Salah D. Kivlighn, Raymond S.L. Chang, William J. Greenlee, Peter K. S. Siegl, Dooseop Kim

Publikováno v: ChemInform. 25

The structure-activity relationships of 6-amido-imidazol [4,5-b]pyridine-based angiostensin II antagonists ( V demonstrate that high affinity for the AT1 and AT2 receptors is largely dependent upon the R1 and R4 substituents. Of this series, L-162,44

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::543aebd983b439c9a4019b0412babc53
https://doi.org/10.1002/chin.199426185

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