Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nathan A. Zautke"'
Autor:
Nevena Mollova, Alexei V. Ivanov, Ian Henderson, Parkhill Eric Q, Jeffrey Chisholm, Kwan Leung, Andrew G. Cole, Sandra A. Brunn, Andrei Glushkov, Dmitry Koltun, Natalya I. Vasilevich, Nathan A. Zautke, Timur Zilbershtein, Jeff Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2048-2052
We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the central bicyclic scaffold has proven key to our potency optimization effort. The most potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae47b61e32bb963232729ec6fd27d146
https://doi.org/10.1016/j.bmcl.2009.02.019
https://doi.org/10.1016/j.bmcl.2009.02.019
Autor:
Ian Henderson, Jeffrey Chisholm, Nathan A. Zautke, Melanie Boze, Jia Hao, Timur Zilbershtein, Natalya I. Vasilevich, Dmitry Koltun, Jeff Zablocki, Elena Mayboroda, Andrei Glushkov, Sandra A. Brunn, Nancy Chu, Parkhill Eric Q, Kwan Leung, Andrew G. Cole, Nevena Mollova
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(11)
We discovered a structurally novel SCD (Delta9 desaturase) inhibitor 4a (CVT-11,563) that has 119 nM potency in a human cell-based (HEPG2) SCD assay and selectivity against Delta5 and Delta6 desaturases. This compound has 90% oral bioavailability (ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267f1f48f3c68a85bf85432fd1bc18f2
https://pubmed.ncbi.nlm.nih.gov/19394219
https://pubmed.ncbi.nlm.nih.gov/19394219
Publikováno v:
The Journal of Trauma: Injury, Infection, and Critical Care. 57:443
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42ddef9c3918f2d601993a8582763867
https://doi.org/10.1097/00005373-200408000-00072
https://doi.org/10.1097/00005373-200408000-00072
Autor:
Watters, Jennifer M, Brundage, Susan I, Todd, S Rob, Zautke, Nathan A, Stefater, J A, Lam, J C, Muller, Patrick J, Malinoski, Darren, Schreiber, Martin A
Publikováno v:
Shock; Sep2004, Vol. 22 Issue 3, p283-287, 5p