Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nathan A. Wigner"'
Autor:
Nathan A. Wigner, Derek J. Donegan
Publikováno v:
Current Orthopaedic Practice. 25:208-212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa852d6b3e29d2b1822a8953f83914d1
https://doi.org/10.1097/bco.0000000000000110
https://doi.org/10.1097/bco.0000000000000110
Autor:
Thomas A. Einhorn, Dana T. Graves, Daniel Cusher, Anna C. Belkina, Sanjeev Kakar, Dana Daukss, Elise F. Morgan, Louis C. Gerstenfeld, Nathan A. Wigner, Maisa O Al-Sebaei
Publikováno v:
Journal of Bone and Mineral Research
Previous studies showed that loss of tumor necrosis factor α (TNFα) signaling delayed fracture healing by delaying chondrocyte apoptosis and cartilage resorption. Mechanistic studies showed that TNFα induced Fas expression within chondrocytes; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05d18c744abfa52efa6c426eca7f9be
http://europepmc.org/articles/PMC4305200
http://europepmc.org/articles/PMC4305200
Publikováno v:
Journal of Cellular Physiology. 228:2232-2242
Runx2 and Runx3 are known to be expressed in the growth plate during endochondral bone formation. Here we addressed the functional role of Runx3 as distinct from Runx2 by using two models of postnatal bone repair: fracture healing that proceeds by an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b37e47c0dc3ce13761acacedcbb8501b
https://doi.org/10.1002/jcp.24396
https://doi.org/10.1002/jcp.24396
Autor:
Katya Ravid, Nathan A. Wigner, Nitin Kulkarni, Louis C. Gerstenfeld, Hillary Johnston-Cox, Shannon H. Carroll
Publikováno v:
Journal of Biological Chemistry. 287:15718-15727
The differentiation of osteoblasts from their precursors, mesenchymal stem cells, is an important component of bone homeostasis as well as fracture healing. The A2B adenosine receptor (A2BAR) is a Gαs/αq-protein-coupled receptor that signals via cA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e558e858ffa1d7882b100c97194796
https://doi.org/10.1074/jbc.m112.344994
https://doi.org/10.1074/jbc.m112.344994
Autor:
Mark Yakavonis, Louis C. Gerstenfeld, Thomas A. Einhorn, Brett D. Meeks, Brian Tinsley, Nathan A. Wigner, Nitin Kulkarni, Megan Young
Publikováno v:
Injury. 43:274-278
Whilst the majority of fractures heal normally, it is estimated that ∼10% of fractures exhibit some level of delayed or impaired healing. Although radiography is the primary diagnostic tool to assess the progression of fracture healing, radiographi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08436649933bbd6b44fd85d618fbad97
https://doi.org/10.1016/j.injury.2011.05.038
https://doi.org/10.1016/j.injury.2011.05.038
Autor:
Graciela Bauzá, George Miller, Neema Kaseje, Louis C. Gerstenfeld, Peter A. Burke, Nathan A. Wigner, Zhongyan Wang
Publikováno v:
Journal of Trauma: Injury, Infection & Critical Care. 70:948-953
BACKGROUND:: The acute-phase response (APR) is critical to the body's ability to successfully respond to injury. A murine model of closed unilateral femur fractures and bilateral femur fracture were used to study the effect of injury magnitude on thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d79ed83b8ad3996b9bde781947006a
https://doi.org/10.1097/ta.0b013e3181e1d27b
https://doi.org/10.1097/ta.0b013e3181e1d27b
Autor:
Thomas A. Einhorn, Kristy T. Salisbury Palomares, Louis C. Gerstenfeld, Nathan A. Wigner, Elise F. Morgan, Marc E. Lenburg
Publikováno v:
Arthritis & Rheumatism. 62:1108-1118
Articular cartilage injuries and degenerative joint diseases such as osteoarthritis pose significant treatment challenges due to the insufficiency of the natural repair response in damaged joint tissues. In recent years, techniques such as microfract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2dab1e55024eb25837595779c1f44d
https://doi.org/10.1002/art.27343
https://doi.org/10.1002/art.27343
Autor:
Zachary D. Mason, A. David Davis, Nathan A. Wigner, Louis C. Gerstenfeld, Elise F. Morgan, Thomas A. Einhorn, Gavin B. Bishop
Publikováno v:
Bone. 43:1031-1038
Fracture healing involves multiple stages of repair and coordinated actions of multiple cell types. Consequently, it may be possible to enhance healing through treatment strategies that target more than one repair process or cell type. The goal of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0979ec0143e31d80e7ebbd67ac72bd
https://doi.org/10.1016/j.bone.2008.07.251
https://doi.org/10.1016/j.bone.2008.07.251
Autor:
Michael Song, Sanjeev Kakar, Maisa O Al-Sebaei, Kimberly A. Jacobsen, Lincoln J Miara, George L. Barnes, Philip C. Trackman, Gregory Hon, Elise F. Morgan, Nathan A. Wigner, Louis C. Gerstenfeld, Daniel Toben, Thomas A. Einhorn, Siddharth R. Vora
Publikováno v:
Journal of Bone and Mineral Research. 22:1903-1912
Studies have shown that systemic PTH treatment enhanced the rate of bone repair in rodent models. However, the mechanisms through which PTH affects bone repair have not been elucidated. In these studies we show that PTH primarily enhanced the earlies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb356a4fab682058cd61c97a8bf8e912
https://doi.org/10.1359/jbmr.070724
https://doi.org/10.1359/jbmr.070724
Publikováno v:
Journal of cellular physiology. 228(11)
Runx2 and Runx3 are known to be expressed in the growth plate during endochondral bone formation. Here we addressed the functional role of Runx3 as distinct from Runx2 by using two models of postnatal bone repair: fracture healing that proceeds by an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7cb3c21558b36ac0e0ea1419efea1d87
https://pubmed.ncbi.nlm.nih.gov/23625810
https://pubmed.ncbi.nlm.nih.gov/23625810