Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nathan A. Truchan"'
Autor:
Austin Reuter, Samantha Pabich, Rachel J. Fenske, Alicia M Weeks, Dawn Belt Davis, Chinmai Patibandla, Elizabeth D. Cox, Harpreet K Sandhu, Randall Nall, Cecilia E Kaiser, Margaret Punt, Nathan A. Truchan, Allison L. Brill, Michelle E. Kimple, Darby C. Peter, Benjamin Wancewicz, Ying Ge, Jeffrey M. Harrington, Michael Daniels
Publikováno v:
ACS Pharmacol Transl Sci
We and others previously reported increased signaling through the Prostaglandin E3 Receptor (EP3), a G protein-coupled receptor (GPCR) for the arachidonic acid metabolite, prostaglandin E2 (PGE2), is associated with {beta}-cell dysfunction of type 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498dcd0cf9582fe7fd0a0ca4994b64f1
https://doi.org/10.1021/acsptsci.1c00045
https://doi.org/10.1021/acsptsci.1c00045
Autor:
Yudong Song, Luke Bugada, Ruiting Li, Hongxiang Hu, Luchen Zhang, Chengyi Li, Hebao Yuan, Krishani Kumari Rajanayake, Nathan A. Truchan, Fei Wen, Wei Gao, Duxin Sun
Publikováno v:
Sci Transl Med
Immunomodulators that remodel the tumor immunosuppressive microenvironment have been combined with anti–programmed death 1 (α-PD1) or anti–programmed death ligand 1 (α-PDL1) immunotherapy but have shown limited success in clinical trials. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fbee0829c9ed83b35cdb2592ee07e3
https://doi.org/10.1126/scitranslmed.abl3649
https://doi.org/10.1126/scitranslmed.abl3649
Autor:
Sushant Bhatnagar, Angie T Oler, Mary E Rabaglia, Donald S Stapleton, Kathryn L Schueler, Nathan A Truchan, Sara L Worzella, Jonathan P Stoehr, Susanne M Clee, Brian S Yandell, Mark P Keller, Debbie C Thurmond, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002323 (2011)
We previously mapped a type 2 diabetes (T2D) locus on chromosome 16 (Chr 16) in an F2 intercross from the BTBR T (+) tf (BTBR) Lep(ob/ob) and C57BL/6 (B6) Lep(ob/ob) mouse strains. Introgression of BTBR Chr 16 into B6 mice resulted in a consomic mous
Externí odkaz:
https://doaj.org/article/f5f6a4e093c04a5b93c5c3211496fac1
Autor:
Mark Cadena, Quincy Eckert Harenda, Michelle E. Kimple, Harpreet K. Brar, Erin Laundre, Jaclyn A. Wisinski, Haley Wienkes, Rachel J. Fenske, Feyza Engin, Kathryn A. Carbajal, Jinjin Cai, Allison L. Brill, Timothy E. Graham, Michael D. Schaid, Nathan A. Truchan
Publikováno v:
Endocrinology. 158:1645-1658
The α-subunit of the heterotrimeric Gz protein, Gαz, promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gαz protein would preserve functional β-cell mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e38097c30271c3b225bcbcfa7ad6d26
https://doi.org/10.1210/en.2016-1700
https://doi.org/10.1210/en.2016-1700
Autor:
Nathan A. Truchan, Buchanan R, Austin Reuter, Harpreet K Sandhu, Rachel J. Fenske, Michelle E. Kimple, Jeffrey M. Harrington, Moeller J
ObjectiveSignaling through Prostaglandin E3 Receptor (EP3), a G protein-coupled receptor for E series prostaglandins such as prostaglandin E2(PGE2), has been linked to the beta-cell dysfunction and loss of beta-cell mass in type 2 diabetes (T2D). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d5df1b5668095b178d7356a6e3122
Autor:
Rashpal S. Dhillon, Luis A. Fernandez, Sophia M. Sdao, Emma L. Baar, Jeremy D. Rogers, Dudley W. Lamming, Brian A. Schmidt, Kevin W. Eliceiri, Nathan A. Truchan, Chetan Poudel, Matthew J. Merrins, Trillian Gregg, John M. Denu, Michelle E. Kimple
Publikováno v:
Diabetes
Aging is accompanied by impaired glucose homeostasis and an increased risk of type 2 diabetes, culminating in the failure of insulin secretion from pancreatic β-cells. To investigate the effects of age on β-cell metabolism, we established a novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3da9d0bb875e9105642b0016c380fb
https://doi.org/10.2337/db16-0432
https://doi.org/10.2337/db16-0432
Autor:
Jennifer B. Moss, Renee L. Pasker, Nathan A. Truchan, Harpreet K. Brar, Taylor C. Rosa, Christopher B. Newgard, Michelle E. Kimple, Patrick J. Casey
Publikováno v:
Journal of Biological Chemistry. 287:20344-20355
Insufficient plasma insulin levels caused by deficits in both pancreatic β-cell function and mass contribute to the pathogenesis of type 2 diabetes. This loss of insulin-producing capacity is termed β-cell decompensation. Our work is focused on def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9be8deaf64cf3574bfe1f9d34581dd1
https://doi.org/10.1074/jbc.m112.359745
https://doi.org/10.1074/jbc.m112.359745
Autor:
Nathan A. Truchan, Michelle E. Kimple, Harpreet K. Brar, Shannon J. Gallagher, Joshua C. Neuman
Publikováno v:
Islets. 7(3)
One complication to comparing β-cell function among islet preparations, whether from genetically identical or diverse animals or human organ donors, is the number of islets required per assay. Islet numbers can be limiting, meaning that fewer condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b10168a545c55ad247bde1d004a0a48
https://pubmed.ncbi.nlm.nih.gov/26452321
https://pubmed.ncbi.nlm.nih.gov/26452321
Publikováno v:
The FASEB Journal. 29
In type 1 diabetes (T1D), an autoimmune insulitis leads to β-cell death. The non-obese diabetic (NOD) mouse model mimics these facets of the human disease. Our laboratory has previously shown that ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fb23549a0991e141bcc64ae7824ccc5
https://doi.org/10.1096/fasebj.29.1_supplement.973.1
https://doi.org/10.1096/fasebj.29.1_supplement.973.1
Publikováno v:
Journal of Visualized Experiments.
Uncontrolled glycemia is a hallmark of diabetes mellitus and promotes morbidities like neuropathy, nephropathy, and retinopathy. With the increasing prevalence of diabetes, both immune-mediated type 1 and obesity-linked type 2, studies aimed at delin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373d448e07eabe2845b5a20e39dbf39e
https://doi.org/10.3791/50374
https://doi.org/10.3791/50374