Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nathan A. Hatcher"'
Autor:
Cheryl E. G. Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G. Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M. Van Deerlin, John Q. Trojanowski, Virginia M. Y. Lee, Matthew E. Kennedy, Matthew J. Fell, Michael X. Henderson
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in the form of Lewy pathology. While most cases are sporadic, there are rar
Externí odkaz:
https://doaj.org/article/ffdac8823595475f8729dc4c771b2777
Autor:
Santhosh Satapati, Daniel P. Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Yingjiang Zhou, Zhao Ren, Michelle Chen, Yeon-Hee Lim, Nathan G. Hatcher, Xiujuan Wen, Payal R. Sheth, David G. McLaren, Stephen F. Previs
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 20-28 (2022)
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions. A
Externí odkaz:
https://doaj.org/article/103ba40a3e5a45859c5af8ed7bf87a21
Autor:
Nanyan Rena Zhang, Nathan G. Hatcher, Kim Ekroos, Komal Kedia, Monika Kandebo, Jacob N. Marcus, Sean M. Smith, Kevin P. Bateman, Daniel S. Spellman
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100218- (2022)
A major challenge of lipidomics is to determine and quantify the precise content of complex lipidomes to the exact lipid molecular species. Often, multiple methods are needed to achieve sufficient lipidomic coverage to make these determinations. Mult
Externí odkaz:
https://doaj.org/article/dab7af844e374932baf5dd7f758560ce
Autor:
Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A. Gretzula, Monika Kandebo, Dawn Toolan, Nathan G. Hatcher, Lei Ma, Wei Lemaire, Gregory C. Adam, Christine Burlein, Christina Minnick, Rose Flick, Marla L. Watt, James Mulhearn, Mark Fraley, Robert E. Drolet, Jacob N. Marcus, Sean M. Smith
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSp
Externí odkaz:
https://doaj.org/article/5bb119e476704557a1fe920f9ef43979
Publikováno v:
Proteomes, Vol 10, Iss 3, p 26 (2022)
Alzheimer’s disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline. The two cardinal neuropathological hallmarks of AD include the buildup of cerebral β amyloid (Aβ) plaques and neurofibrillary ta
Externí odkaz:
https://doaj.org/article/ce2f195e94ef497a90be7e3c28059353
Autor:
Anthony J. Roecker, Kathy M. Schirripa, H. Marie Loughran, Ling Tong, Tao Liang, Kerry L. Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D. Altman, Melissa C. Ford, Robert E. Drolet, Mali Cosden, Sarah Jinn, Nathan G. Hatcher, Lihang Yao, Monika Kandebo, Joshua D. Vardigan, Rosemarie B. Flick, Xiaomei Liu, Christina Minnick, Laura A. Price, Marla L. Watt, Wei Lemaire, Christine Burlein, Gregory C. Adam, Lauren A. Austin, Jacob N. Marcus, Sean M. Smith, Mark E. Fraley
Publikováno v:
ACS Medicinal Chemistry Letters. 14:146-155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a75f2713f77a436a3c71e753c7d659
https://doi.org/10.1021/acsmedchemlett.2c00441
https://doi.org/10.1021/acsmedchemlett.2c00441
Autor:
Emily M. Rocha, Briana R. De Miranda, Sandra Castro, Robert Drolet, Nathan G. Hatcher, Lihang Yao, Sean M. Smith, Matthew T. Keeney, Roberto Di Maio, Julia Kofler, Teresa G. Hastings, J. Timothy Greenamyre
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
LRRK2 has been implicated in endolysosomal function and likely plays a central role in idiopathic Parkinson's disease (iPD). In iPD, dopaminergic neurons within the substantia nigra are characterized by increased LRRK2 kinase activity, endolysosomal
Externí odkaz:
https://doaj.org/article/b76d6613c5e54dbdb50a6161ab538feb
Autor:
Casey L. Mahoney-Crane, Megha Viswanathan, Dreson Russell, Rachel A.C. Curtiss, Jennifer Freire, Sai Sumedha Bobba, Sean D. Coyle, Monika Kandebo, Lihang Yao, Bang-Lin Wan, Nathan G. Hatcher, Sean M. Smith, Jacob N. Marcus, Laura A. Volpicelli-Daley
Publikováno v:
The Journal of Neuroscience. 43:501-521
The most common genetic risk factor for Parkinson's disease (PD) is heterozygous mutationsGBA1, which encodes for the lysosomal enzyme, glucocerebrosidase. Reduced glucocerebrosidase activity associates with an accumulation of abnormal α-synuclein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e53fa31184f65b618e50145e3c5d29
https://doi.org/10.1523/jneurosci.0680-22.2022
https://doi.org/10.1523/jneurosci.0680-22.2022
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102240 (2014)
Many cost-benefit decisions reduce to simple choices between approach or avoidance (or active disregard) to salient stimuli. Physiologically, critical factors in such decisions are modulators of the homeostatic neural networks that bias decision proc
Externí odkaz:
https://doaj.org/article/b154cdbcc25b451a8d34dd62390079e9
Autor:
Kim Ekroos, Nathan G. Hatcher, Lihang Yao, Melissa Sherman, Gregory Van Aken, Daniel DeBord, Laura Maxon, Kelly L Wormwood Moser
Publikováno v:
Analytica chimica acta. 1146
Defects in sphingolipid metabolism have emerged as a common link across neurodegenerative disorders, and a deeper understanding of the lipid content in preclinical models and patient specimens offers opportunities for development of new therapeutic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43b0206d1dce94f3b4cd438ac4d14e7
https://pubmed.ncbi.nlm.nih.gov/33461722
https://pubmed.ncbi.nlm.nih.gov/33461722