Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Nathan A. Clark"'
Autor:
Catalina Pereira, Gerardo A Arroyo-Martinez, Matthew Z Guo, Michael S Downey, Emma R Kelly, Kathryn J Grive, Shantha K Mahadevaiah, Jennie R Sims, Vitor M Faca, Charlton Tsai, Carl J Schiltz, Niek Wit, Heinz Jacobs, Nathan L Clark, Raimundo Freire, James Turner, Amy M Lyndaker, Miguel A Brieno-Enriquez, Paula E Cohen, Marcus B Smolka, Robert S Weiss
Publikováno v:
eLife, Vol 11 (2022)
DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A an
Externí odkaz:
https://doaj.org/article/57deb83a4c11495681d45121899c60e3
Publikováno v:
eLife, Vol 11 (2022)
Vertebrates evolved mechanisms for sodium conservation and gas exchange in conjunction with migration from aquatic to terrestrial habitats. Epithelial Na+ channel (ENaC) function is critical to systems responsible for extracellular fluid homeostasis
Externí odkaz:
https://doaj.org/article/2071508c1cb94448b6e38bf0be4ac560
Autor:
Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Homologous recombination (HR) is an essential DNA repair pathway for genomic stability. Here the authors show that C17orf53/MCM8IP, an OB-fold containing protein, promotes HR through direct binding and activation of the MCM8-9 helicase complex.
Externí odkaz:
https://doaj.org/article/86fa91a9e36c4bd1bfde918a8bfb93ee
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 6 (2021)
AbstractBaker’s yeast contains a large number of duplicated genes; some function redundantly, whereas others have more specialized roles. We used the MLH family of DNA mismatch repair (MMR) proteins as a model to better understand the steps that le
Externí odkaz:
https://doaj.org/article/f4e301790a1f4db8a9548b50e7079f60
Autor:
Dana M Talsness, Katie G Owings, Emily Coelho, Gaelle Mercenne, John M Pleinis, Raghavendran Partha, Kevin A Hope, Aamir R Zuberi, Nathan L Clark, Cathleen M Lutz, Aylin R Rodan, Clement Y Chow
Publikováno v:
eLife, Vol 9 (2020)
N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears. To model the phenotypic variab
Externí odkaz:
https://doaj.org/article/b15615d75fd24af79e4e3c0481b7aa57
Autor:
Alfonso J. Tafur, Nathan P. Clark, Alex C. Spyropoulos, Na Li, Eric Kaplovitch, Kira MacDougall, Sam Schulman, Joseph A. Caprini, James Douketis
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 19 (2020)
Background In the PAUSE (Perioperative Anticoagulant Use for Surgery Evaluation) Study, a simple, standardized, perioperative interruption strategy was provided for patients with nonvalvular atrial fibrillation taking direct oral anticoagulants (DOAC
Externí odkaz:
https://doaj.org/article/7de21de30c804f2ea1f38fd8e9c77c41
Autor:
Lauren Cline, Erika Marie G. Generoso, Nicholas D’Apice, Sara K. Dellinger, Amber Tovey, Nathan P. Clark, Fang Nui, Rita Hui, Stephanie A. Hale, Tanya Ramsey, Kimi Pontoppidan, Hasmig Ekmekdjian, Kristen Fink, Daniel M. Witt, Mark A. Crowther, Thomas Delate
Publikováno v:
Journal of Thrombosis and Thrombolysis. 55:355-364
Autor:
Kira MacDougall, James D. Douketis, Na Li, Nathan P. Clark, Alfonso Tafur, Julien D'Astous, Joanne Duncan, Sam Schulman, Alex C. Spyropoulos
Publikováno v:
TH Open, Vol 04, Iss 03, Pp e255-e262 (2020)
Introduction The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) Study assessed a standardized perioperative management strategy in patients with atrial fibrillation who were taking a direct oral anticoagulant (DOAC) and required an
Externí odkaz:
https://doaj.org/article/4d1d26a693bc4e7e859f3f38a1187fca
Publikováno v:
eLife, Vol 9 (2020)
Although lifespan in mammals varies over 100-fold, the precise evolutionary mechanisms underlying variation in longevity remain unknown. Species-specific genetic changes have been observed in long-lived species including the naked mole-rat, bats, and
Externí odkaz:
https://doaj.org/article/ba7dace06e084af69dc9a3c87027f940
Autor:
Allie M Graham, Jerrica M Jamison, Marisol Bustos, Charlotte Cournoyer, Alexa Michaels, Jason S Presnell, Rebecca Richter, Daniel E Crocker, Ari Fustukjian, Margaret E Hunter, Lorrie D Rea, Judit Marsillach, Clement E Furlong, Wynn K Meyer, Nathan L Clark
Publikováno v:
Molecular Biology and Evolution. 40
Convergent adaptation to the same environment by multiple lineages frequently involves rapid evolutionary change at the same genes, implicating these genes as important for environmental adaptation. Such adaptive molecular changes may yield either ch