Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nathan A Groathouse"'
Autor:
Becky L Rivoire, Nathan A Groathouse, Stephen TerLouw, Kapil Dev Neupane, Chaman Ranjit, Bishwa Raj Sapkota, Saraswoti Khadge, Chhatra B Kunwar, Murdo Macdonald, Rachel Hawksworth, Min B Thapa, Deanna A Hagge, Melinda Tibbals, Carol Smith, Tina Dube, Dewei She, Mark Wolff, Eric Zhou, Mamodikoe Makhene, Robin Mason, Christine Sizemore, Patrick J Brennan
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2811 (2014)
New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in human trial
Externí odkaz:
https://doaj.org/article/7e1eeddeb5ad4ae4898d8b0c85f7af5a
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2791 (2014)
True incidence of leprosy and its impact on transmission will not be understood until a tool is available to measure pre-symptomatic infection. Diagnosis of leprosy disease is currently based on clinical symptoms, which on average take 3-10 years to
Externí odkaz:
https://doaj.org/article/40e3bb9e66dd4794a3789d0f034eb511
Publikováno v:
Clinical and Vaccine Immunology. 20:181-190
The cell-mediated immunity (CMI)-based in vitro gamma interferon release assay (IGRA) of Mycobacterium leprae -specific antigens has potential as a promising diagnostic means to detect those individuals in the early stages of M. leprae infection. Dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ff6046bffab5ce6a7e678cdd4a2033
https://doi.org/10.1128/cvi.00419-12
https://doi.org/10.1128/cvi.00419-12
Autor:
Patrick J. Brennan, Nathan A. Groathouse, Amol G. Amin, Maria Angela M. Marques, John T. Belisle, Dennis L. Knudson, Richard A. Slayden, John S. Spencer, Robert H. Gelber
Publikováno v:
Infection and Immunity. 74:6458-6466
Although the global prevalence of leprosy has decreased over the last few decades due to an effective multidrug regimen, large numbers of new cases are still being reported, raising questions as to the ability to identify patients likely to spread di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574655ea0815c5f9a45250bf482b65ab
https://doi.org/10.1128/iai.00041-06
https://doi.org/10.1128/iai.00041-06
Autor:
Dennis L. Knudson, Patrick J. Brennan, Susan E. Brown, Nathan A. Groathouse, Richard A. Slayden
Publikováno v:
Journal of Clinical Microbiology. 44:1502-1508
Molecular diagnostic and epidemiology studies require appreciable amounts of high-quality DNA. Molecular epidemiologic methods have not been routinely applied to the obligate intracellular organism Mycobacterium leprae because of the difficulty of ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c649a9edf2d523bc91980a315915083b
https://doi.org/10.1128/jcm.44.4.1502-1508.2006
https://doi.org/10.1128/jcm.44.4.1502-1508.2006
Autor:
Patrick J. Brennan, Varalakshmi D. Vissa, Hansuk Kim, Sang Nae Cho, Nathan A. Groathouse, Becky Rivoire, Hyeyoung Lee
Publikováno v:
Journal of Clinical Microbiology. 42:1666-1672
The need for molecular tools for the differentiation of isolates of Mycobacterium leprae , the organism that causes leprosy, is urgent in view of the continuing high levels of new case detection, despite years of aggressive chemotherapy and the conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155133c6bf828ba9ed2489fb1b9e0f12
https://doi.org/10.1128/jcm.42.4.1666-1672.2004
https://doi.org/10.1128/jcm.42.4.1666-1672.2004
Autor:
Chaman Ranjit, Bishwa Raj Sapkota, Chhatra B. Kunwar, Patrick J. Brennan, Becky Rivoire, Eric Zhou, Robin Mason, Mark Wolff, Nathan A. Groathouse, RA Hawksworth, Christine Sizemore, Stephen TerLouw, Melinda Tibbals, Saraswoti Khadge, Mamodikoe Makhene, Min B Thapa, Dewei She, Murdo Macdonald, Tina Dube, Carol Smith, Kapil D. Neupane, Deanna A. Hagge
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2811 (2014)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background New tools are required for the diagnosis of pre-symptomatic leprosy towards further reduction of disease burden and its associated reactions. To address this need, two new skin test antigens were developed to assess safety and efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acf393841e8da768aee75fe8b403e40
http://europepmc.org/articles/PMC4038488?pdf=render
http://europepmc.org/articles/PMC4038488?pdf=render
Autor:
Nicholas J Cheronis, John E. Repine, Richard A Bowen, Sanford R. Simon, Nathan A Groathouse, John C. Cheronis
Publikováno v:
Journal of Pulmonary & Respiratory Medicine.
Animal models are often used to identify aspects of the pathophysiology and to develop new therapeutic interventions for human disorders. Leukocyte serine elastases are key mediators of inflammation and meaningful therapeutic targets because of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c128d1ba0a11059655bc11e34233dfff
https://doi.org/10.4172/2161-105x.1000155
https://doi.org/10.4172/2161-105x.1000155
Autor:
Nathan A. Groathouse, Patrick J. Brennan, Becky Rivoire, Miyako Kimura, Sang Nae Cho, David Gingrich, Rama Murthy Sakamuri, Varalakshmi Vissa, Susan Krueger-Koplin
Publikováno v:
Journal of clinical microbiology. 47(6)
Mycobacterium leprae is the noncultivable pathogen of leprosy. Since the genome sequence of an isolate of M. leprae has become available, multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) has been explored as a tool for strain typin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf465cb4e87d03fe214eb792a812e3a4
https://pubmed.ncbi.nlm.nih.gov/19386839
https://pubmed.ncbi.nlm.nih.gov/19386839
Autor:
Patrick J. Brennan, John S. Spencer, Greg C. Ireton, Nathan A. Groathouse, Robert H. Gelber, Wakako Goto, Raodoh Mohamath, Steven G. Reed, Jeffrey A. Guderian, Stephen T. Reece
Despite the success of multidrug therapy in reducing the number of registered leprosy cases worldwide, evidence suggests thatMycobacterium lepraecontinues to be transmitted. A serological diagnostic test capable of identifying and allowing treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e276df72dd461047d7d837368ef498
https://europepmc.org/articles/PMC1391965/
https://europepmc.org/articles/PMC1391965/
