Výsledky vyhledávání - "Nathan A, Snyder"

Akademický článek

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Autor: Nathan A. Snyder, Adam Kim, Louis Kester, Andrew N. Gale, Christian Studer, Dominic Hoepfner, Silvio Roggo, Stephen B. Helliwell, Kyle W. Cunningham

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 829-840 (2019)

Gene knockout and knockdown strategies have been immensely successful probes of gene function, but small molecule inhibitors (SMIs) of gene products allow much greater time resolution and are particularly useful when the targets are essential for cel

Externí odkaz: https://doaj.org/article/3c656557bb5648078cf2ced79446adef

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Akademický článek

H+ and Pi Byproducts of Glycosylation Affect Ca2+ Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1

Autor: Nathan A. Snyder, Christopher P. Stefan, Camille T. Soroudi, Adam Kim, Carlos Evangelista, Kyle W. Cunningham

Publikováno v: G3: Genes, Genomes, Genetics, Vol 7, Iss 12, Pp 3913-3924 (2017)

Glycosylation reactions in the Golgi complex and the endoplasmic reticulum utilize nucleotide sugars as donors and produce inorganic phosphate (Pi) and acid (H+) as byproducts. Here we show that homologs of mammalian XPR1 and TMEM165 (termed Erd1 and

Externí odkaz: https://doaj.org/article/892216a29abd43f2a3e13a43633bbd9f

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Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes

Autor: Vanessa Simões, Blanche K. Cizubu, Lana Harley, Ye Zhou, Joshua Pajak, Nathan A. Snyder, Jonathan Bouvette, Mario J. Borgnia, Gaurav Arya, Alberto Bartesaghi, Gustavo M. Silva

Publikováno v: Cell reports. 39(8)

Protein ubiquitination is an essential process that rapidly regulates protein synthesis, function, and fate in dynamic environments. Within its non-proteolytic functions, we showed that K63-linked polyubiquitinated conjugates heavily accumulate in ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb1e691295d8f9d5691bc3a39a6b538
https://pubmed.ncbi.nlm.nih.gov/35613580

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Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response

Autor: Gustavo M. Silva, Nathan A. Snyder

Publikováno v: The Journal of Biological Chemistry

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability. To regulate this process, deubiquitinating enzymes (DUBs) counte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c743630c2855f90492c29a0b696db4
http://europepmc.org/articles/PMC8424594

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Milk biosynthesis requires the Golgi cation exchanger TMEM165

Autor: Nathan A. Snyder, Mitchell V. Palmer, Kyle W. Cunningham, Timothy A. Reinhardt

Publikováno v: Journal of Biological Chemistry. 294:3181-3191

Milk is a hallmark of mammals that is critical for normal growth and development of offspring. During biosynthesis of lactose in the Golgi complex, H(+) is produced as a by-product, and there is no known mechanism for maintaining luminal pH within th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84de2e63328ed647056aa6f6be6b8bd
https://doi.org/10.1074/jbc.ra118.006270

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Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Autor: Silvio Roggo, Louis Kester, Andrew N. Gale, Dominic Hoepfner, Adam Kim, Christian Studer, Kyle W. Cunningham, Stephen B. Helliwell, Nathan A. Snyder

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 3, Pp 829-840 (2019)
G3: Genes|Genomes|Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e106314c27f8698de9ebf66de56c4130
http://g3journal.org/lookup/doi/10.1534/g3.118.200748

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Teachers' Perceived Advantages and Disadvantages of Using Flipped Classrooms in ELA and Non-ELA Classrooms

Autor: Nathan C. Snyder

As teachers and institutions continue to incorporate the flipped learning model for delivering curricula to students, more needs to be known about its efficacy in the classroom, especially in secondary classrooms, as the majority of published literat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc3804162e19b6336010b5a3c61c37b
https://doi.org/10.4018/978-1-5225-7663-1.ch078

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CaGdt1 plays a compensatory role for the calcium pump CaPmr1 in the regulation of calcium signaling and cell wall integrity signaling in Candida albicans

Autor: Junjun Wang, Faiza Asghar, Nathan A. Snyder, Kyle W. Cunningham, Linghuo Jiang

Publikováno v: Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-16 (2018)

Background Saccharomyces cerevisiae ScGdt1 and mammalian TMEM165 are two members of the UPF0016 membrane protein family that is likely to form a new group of Ca2+/H+ antiporter and/or a Mn2+ transporter in the Golgi apparatus. We have previously show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f4652bd76998e98b124fbfb077c9eb
http://europepmc.org/articles/PMC6025805

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Autor: Nathan A, Snyder, Christopher P, Stefan, Camille T, Soroudi, Adam, Kim, Carlos, Evangelista, Kyle W, Cunningham

Publikováno v: G3: Genes|Genomes|Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30d5a22d0db085374db7448dc38a273a
https://pubmed.ncbi.nlm.nih.gov/29042410

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