Výsledky vyhledávání - "Nathan A, Bracey"

Separation anxiety: Splitting PD-L1 from CD80 suppresses autoimmunity

Autor: Nathan A. Bracey, Jonathan S. Maltzman

Publikováno v: Science Immunology. 7

A monoclonal antibody targeting CD80 on antigen presenting cells disrupts cis-interactions with PD-L1, reviving T cell inhibitory checkpoint signaling to suppress autoimmunity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c3fea3dc423fd4fe8cdd38972174d5e
https://doi.org/10.1126/sciimmunol.abq1728

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Tissue-selective alternate promoters guide NLRP6 expression

Autor: Nathan A. Bracey, Justin Chun, M. Eric Hyndman, Paul M. K. Gordon, Stephen E. Girardin, Jaye M. Platnich, Hyunjae Chung, Justin A. MacDonald, Daniel A. Muruve, Paul L. Beck, Arthur Lau

Publikováno v: Life Science Alliance

The NLRP6 innate immune sensor is regulated by tissue-selective alternate promoters that facilitate translational gene silencing outside of the intestinal epithelium in both humans and mice.
The pryin domain (PYD) domain is involved in protein i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f9fdfab277f5fb9fc89e94ffd79b7
http://europepmc.org/articles/PMC7772780

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Argyria caused by chronic ingestion of silver

Autor: David N. Juurlink, Nathan A. Bracey, Jonathan S. Zipursky

An 84-year-old woman was referred to our clinic with grey discolouration of her face. She had a history of hypertension that was managed with amlodipine and olmesartan. She reported that she had ingested an ionic silver solution (1 mg/mL), which she

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b304e9469b66f20eb474e4e75e7ddef5
https://europepmc.org/articles/PMC5798984/

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Hierarchical Regulation of Wound Healing by NOD-Like Receptors in Cardiovascular Disease

Autor: Nathan A. Bracey, Daniel A. Muruve, Henry J. Duff

Publikováno v: Antioxidants & Redox Signaling. 22:1176-1187

Persistent nonmicrobial tissue injury leads to the nonlinear activation of integrated wound-healing pathways. In chronic cardiovascular diseases, local tissue undergoes dynamic remodeling involving both structural cells and professional innate immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1606e93ff7c7c22210874808f2856ed
https://doi.org/10.1089/ars.2014.6125

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Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome

Autor: Justin Chun, James R. Wright, Henry J. Duff, Paul W.M. Fedak, Daniel A. Muruve, H. Christopher Meijndert, Benjamin Gershkovich, Paul L. Beck, Nathan A. Bracey, Akosua Vilaysane

Publikováno v: Journal of Biological Chemistry. 289:19571-19584

Nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) is a pattern recognition receptor that is implicated in the pathogenesis of inflammation and chronic diseases. Although much is known regarding the NLRP3 inflammasome that reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fef17218ed755addadee06ed8a759e
https://doi.org/10.1074/jbc.m114.550624

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The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β

Autor: Simon A. Hirota, Habib Jabagi, James R. Wright, Nathan A. Bracey, Daniel A. Muruve, Lisa M. Semeniuk, Justin A. MacDonald, Henry J. Duff, Jiqing Guo, Daniel Roach, Paul L. Beck, James P. Lees-Miller

Publikováno v: Experimental Physiology. 98:462-472

Heart failure is associated with a low-grade and chronic cardiac inflammation that impairs function; however, the mechanisms by which this sterile inflammation occurs in structural heart disease remain poorly defined. Cardiac-specific heterozygous ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e32556ec61bd78d230a02e1977629150
https://doi.org/10.1113/expphysiol.2012.068338

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Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β

Autor: Chunhua Shi, James C. Cross, Darrell D. Belke, Xiang Zhao, Guoqi Teng, Henry J. Duff, Edward R. O'Brien, Nathan A. Bracey, Paul W.M. Fedak, James P. Lees-Miller, Yong-Xiang Chen

Publikováno v: Circulation. Arrhythmia and electrophysiology. 8(2)

Background— N629D KCNH2 is a human missense long-QT2 mutation. Previously, we reported that the N629D/N629D mutation embryos disrupted cardiac looping, right ventricle development, and ablated I Kr activity at E9.5. The present study evaluates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d841bff53d4be02c0376db87d9dfab
https://pubmed.ncbi.nlm.nih.gov/25900989

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Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium

Autor: Sharon A. Clark, Akosua Vilaysane, Justin Chun, Henry J. Duff, Kiril Trpkov, Shirin Bonni, Gabrielle French, Wenjie Wang, Nathan A. Bracey, Xiangyu Wang, Paul L. Beck, Daniel A. Muruve

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 190(3)

Tubulointerstitial inflammation and fibrosis are strongly associated with the outcome of chronic kidney disease. We recently demonstrated that the NOD-like receptor, pyrin domain containing-3 (NLRP3) contributes to renal inflammation, injury, and fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5850181481801f3f7185a8d6a38caa47
https://pubmed.ncbi.nlm.nih.gov/23264657

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