Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nathan, Yoganathan"'
Autor:
Mayra Trentin-Sonoda, Joseph Zimpelmann, Karishma Tailor, John W. Gillard, Nathan Yoganathan, Traian Sulea, Kevin D. Burns
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 10 (2023)
Background: Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin (Ang) II to Ang-(1-7), promoting vasodilatation, and inhibiting oxidative stress and inflammation. Plasma membrane ACE2 is the receptor for all known SARS-CoV-2 (severe acute r
Externí odkaz:
https://doaj.org/article/ad4d0e9cf9494a689a3481920aa10e84
Autor:
Etienne, Lessard, Kerry, Rennie, Arsalan, Haqqani, Binbing, Ling, James, Whitfield, Andrea, Paradis, Joseph, Araujo, Nathan, Yoganathan, John, Gillard, Danica, Stanimirovic, Balu, Chakravarthy
Publikováno v:
Pharmaceutical Research. 39:1497-1507
Purpose We have recently demonstrated the brain-delivery of an Amyloid-ß oligomer (Aßo)-binding peptide-therapeutic fused to the BBB-crossing single domain antibody FC5. The bi-functional fusion protein, FC5-mFc-ABP (KG207-M) lowered both CSF and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8352decebaeedc0494444945852056f5
https://doi.org/10.1007/s11095-022-03285-z
https://doi.org/10.1007/s11095-022-03285-z
Autor:
A. Claudio Cuello, Sulantha Mathotaarachchi, Julie Ottoy, Kerry Rennie, Arturo Aliaga, D. Louis Collins, Danica Stanimirovic, Nathan Yoganathan, Serge Gauthier, Pedro Rosa-Neto, Etienne Lessard, Tharick A. Pascoal, Balu Chakravarthy, Monica Shin, Axel Mathieu, Min Su Kang, Kely Quispialaya, Kaj Blennow, M. Mallar Chakravarty, Arsalan S. Haqqani, Michael Waterston, Jean-Paul Soucy, Henrik Zetterberg, Åsa Sandelius, Gassan Massarweh
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:788-801
In vivo biomarker abnormalities provide measures to monitor therapeutic interventions targeting amyloid-β pathology as well as its effects on downstream processes associated with Alzheimer’s disease pathophysiology. Here, we applied an in vivo lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::392a5503e19a3ed64764211d7fe8051a
https://doi.org/10.1177/0271678x211035625
https://doi.org/10.1177/0271678x211035625
Autor:
Min Su, Kang, Monica, Shin, Julie, Ottoy, Arturo Aliaga, Aliaga, Sulantha, Mathotaarachchi, Kely, Quispialaya, Tharick A, Pascoal, D Louis, Collins, M Mallar, Chakravarty, Axel, Mathieu, Åsa, Sandelius, Kaj, Blennow, Henrik, Zetterberg, Gassan, Massarweh, Jean-Paul, Soucy, A Claudio, Cuello, Serge, Gauthier, Michael, Waterston, Nathan, Yoganathan, Etienne, Lessard, Arsalan, Haqqani, Kerry, Rennie, Danica, Stanimirovic, Balu, Chakravarthy, Pedro, Rosa-Neto
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 42(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ad751f7b4cc0e2b0c1bf3ea3c1a9a2b
https://pubmed.ncbi.nlm.nih.gov/34378436
https://pubmed.ncbi.nlm.nih.gov/34378436
Autor:
Julie Haukenfrers, Robert Pon, Trevor Atkinson, Joseph S. Tauskela, Arsalan S. Haqqani, Danica Stanimirovic, Christie Delaney, Kerry Rennie, Rosa Comas, Jim Callaway, Renu Dudani, Balu Chakravarthy, Claudie Charlebois, Ganesh Guhados, Michael J McCluskie, Michel Ménard, Amy Aylsworth, John W. Gillard, Gerard Agbayani, Nathan Yoganathan, Eric Brunette, Susan Jiang, Craig Bihun, Bassel Akache
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f54d8b12f563436b1d922f02d6789b4
https://doi.org/10.1002/alz.044198
https://doi.org/10.1002/alz.044198
Autor:
Danica Stanimirovic, Alexandra T. Star, Nathan Yoganathan, Pedro Rosa-Neto, Balu Chakravarthy, Marguerite Ball, Michel Ménard, Alex Pelletier, James F. Whitfield, Christie Delaney, Kerry Rennie, Eric Grazzini, Susan Jiang, Trevor Atkinson, Leslie Brown, Eric Brunette, Martin N. Perkins, Arsalan S. Haqqani, Etienne Lessard, Wen Ding, Yves Durocher, Marie Parat, Ewa Baumann, Michael Waterston
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa61338d65a3d5c264b7ca79df8168d
https://doi.org/10.1016/j.jalz.2017.06.703
https://doi.org/10.1016/j.jalz.2017.06.703
Autor:
Min Su Kang, Jean-Paul Soucy, Pedro Rosa-Neto, Monica Shin, Michael Waterston, Louis Collins, Serge Gauthier, Claudio Cuello, Christie Delaney, Arsalan S. Haqqani, Leslie Brown, Kerry Rennie, Balu Chakravarthy, Alex Pelletier, Yves Durocher, Nathan Yoganathan, Danica Stanimirovic, Gassan Massarweh
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ea30cd6356da8fef62bd0564aa26ae4
https://doi.org/10.1016/j.jalz.2017.07.224
https://doi.org/10.1016/j.jalz.2017.07.224
Autor:
Phuong Uyen Le, Kevin Petrecca, Abdolali Amiri, Alexandre Moquin, Gayane Machkalyan, Nathan Yoganathan, Dusica Maysinger, John W. Gillard
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 109
Carbonic anhydrase IX (CAIX) is a transmembrane enzyme upregulated in several types of tumors including glioblastoma multiforme (GBM). GBM is among the most aggressive tumors among gliomas. Temozolomide (TMZ) therapy combined with surgical or radiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98834a9d271e5d09f3d65d89081ffb73
https://pubmed.ncbi.nlm.nih.gov/27702686
https://pubmed.ncbi.nlm.nih.gov/27702686
Autor:
Nathan Yoganathan
Publikováno v:
BMC Proceedings
According to American Cancer Society projections for 2014, approximately 1.5 million new cancers are expected to be diagnosed and more than several hundred patients are expected to die of cancer, with more than 90% of these cancers being solid tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7ed77c675fc5be29652b022b7e3630
https://doi.org/10.1186/1753-6561-8-s4-o16
https://doi.org/10.1186/1753-6561-8-s4-o16
Autor:
Penny Costello, Jun Yan, Dan Leung, Mojgan Jabali, Shoukat Dedhar, T. Nathan Yoganathan, Arthur Yee, Zaihui Zhang, Jasbinder Sanghera, Xiaoyi Chen
Publikováno v:
Biochemical Pharmacology. 60:1115-1119
Integrin-mediated cell adhesion is known to regulate gene expression through the activation of transcription factors. We have recently revealed that these activations are mediated through integrin-linked kinase (ILK). ILK is an ankyrin repeat-contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7094cff977f0e1aa78f6c62cf94719
https://doi.org/10.1016/s0006-2952(00)00444-5
https://doi.org/10.1016/s0006-2952(00)00444-5