Výsledky vyhledávání - "Nathan, Trim"

Impaired Proteolysis of Collagen I Inhibits Proliferation of Hepatic Stellate Cells

Autor: Nathan Trim, John P. Iredale, James Chan, Andrew Nash, Xiaoying Zhou, Aqeel Jamil, R. Christopher Benyon

Publikováno v: Journal of Biological Chemistry. 281:39757-39765

Myofibroblastic-activated hepatic stellate cells are the major source of the collagen I-rich extracellular matrix in liver fibrosis but also produce matrix metalloproteinases, which remodel this protein. We have investigated the role of collagen I pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e07dc5eab581e9b63c1216d7b7176839
https://doi.org/10.1074/jbc.m605621200

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Hepatocytes Express Nerve Growth Factor during Liver Injury

Autor: John P. Iredale, Christothea M. Constandinou, Kenneth J. Hillan, Derek A. Mann, R. Christopher Benyon, Timothy J. Kendall, Fiona Oakley, Nathan Trim, Alane M. Gray, Gretchen Frantz, Weilan Ye

Publikováno v: The American Journal of Pathology. 163:1849-1858

A key feature of recovery from liver fibrosis is hepatic stellate cell (HSC) apoptosis, which serves the dual function of removing the major source of neomatrix and tissue inhibitors of metalloproteinases thereby facilitating matrix degradation. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89278a09fe23a6fa50adc8a2ff8ff2d4
https://doi.org/10.1016/s0002-9440(10)63544-4

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Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo

Autor: Elizabeth J. Williams, B H Grove, RC Benyon, John P. Iredale, E N Unemori, Michael J. P. Arthur, R Hadwin, Nathan Trim

Publikováno v: Gut. 49:577-583

BACKGROUND—Following liver injury, hepatic stellate cells (HSC) transform into myofibroblast-like cells (activation) and are the major source of type I collagen and the potent collagenase inhibitors tissue inhibitors of metalloproteinases 1 and 2 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceba680f1a2659eb68b134c842c5643
https://doi.org/10.1136/gut.49.4.577

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The role of cAMP in the actions of the peptide AF3 in the parasitic nematodes Ascaris suum and Ascaridia galli

Autor: Lindy Holden-Dye, Julie E Brooman, Nathan Trim, Robert J. Walker

Publikováno v: Molecular and Biochemical Parasitology. 93:263-271

AF3 (AVPGVLRFamide) is an endogenous RFamide-like peptide isolated from the parasitic nematode Ascaris suum. It has a potent and long lasting excitatory effect in A. suum and Ascaridia galli. This is mediated by a mechanism independent of the nicotin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2f3cdfefbc36f67349d682cd5b7abd
https://doi.org/10.1016/s0166-6851(98)00039-5

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Mutation in collagen‐I that confers resistance to the action of collagenase results in failure of recovery from CCl4‐induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration

Autor: Nathan Trim, John P. Iredale, Xiaoying Zhou, Razao Issa, Christopher Benyon, Harry Millward-Sadler, Stephen M. Krane

Publikováno v: The FASEB Journal. 17:47-49

Collagen-I, which predominates in the neomatrix of fibrotic liver, regulates hepatocyte and hepatic stellate cell (HSC) phenotypes. Recovery from liver fibrosis is accompanied by hepatocyte regeneration, matrix degradation, and HSC apoptosis. Using m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb8288c79e4f37100481651f22d2015f
https://doi.org/10.1096/fj.02-0494fje

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Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis

Autor: Xiaoying, Zhou, Aqeel, Jamil, Andrew, Nash, James, Chan, Nathan, Trim, John P, Iredale, R Christopher, Benyon

Publikováno v: The Journal of biological chemistry. 281(52)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33a8be8f7497e866c1cf33f0568d1869
https://pubmed.ncbi.nlm.nih.gov/17060319

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Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking

Autor: Jonathan A. Fallowfield, Emma Sands, Andreas Knorr, Xiaoying Zhou, R. Christopher Benyon, Michael J. P. Arthur, Marianna D. A. Gaça, Nathan Trim, John P. Iredale, Christothea M. Constandinou, Ibnauf Suliman, Razao Issa, Harry Millward-Sadler

Publikováno v: Gastroenterology. 126(7)

Background & Aims: Liver fibrosis and cirrhosis result from the excessive secretion of matrix proteins by hepatic stellate cells (HSCs). Previously considered irreversible, we have studied a model of cirrhosis to determine the mechanisms mediating an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45666739212ee371e530d269d7ba11f9
https://pubmed.ncbi.nlm.nih.gov/15188175

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Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration

Autor: Razao, Issa, Xiaoying, Zhou, Nathan, Trim, Harry, Millward-Sadler, Stephen, Krane, Christopher, Benyon, John, Iredale

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a861bcfdc01cac55f7a167d5c1152afd
https://pubmed.ncbi.nlm.nih.gov/12475903

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Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats

Autor: John P. Iredale, Michael J. P. Arthur, Razo Issa, John N. Primrose, Nathan Trim, Matthew C. Wright, Derek A. Mann, David E. Smart, Graeme I. Murray

Publikováno v: Gastroenterology. 121(3)

Background & Aims: Hepatic stellate cells (HSCs) play a pivotal role in liver fibrosis and stimulating their apoptosis could be an effective treatment for liver fibrosis. Methods: Activated HSCs, hepatocytes, and rats with liver fibrosis were treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a902b7126cdd9415a85519a1cf37e0f8
https://pubmed.ncbi.nlm.nih.gov/11522753

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Hepatic Stellate Cells Express the Low Affinity Nerve Growth Factor Receptor p75 and Undergo Apoptosis in Response to Nerve Growth Factor Stimulation

Autor: David R. Fine, Martyn Evans, Razao Issa, Sue Morgan, Bridget S. Wilkins, Nathan Trim, Simon C. Afford, John P. Iredale

We have examined the expression of p75, a member of the TNF receptor superfamily in hepatic stellate cells (HSC) and pancreatic stellate cells (PSC). Activated HSC and PSC were demonstrated by Western blot analysis to express p75. p75 was immunolocal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec2c1fea4eb2e9b8e0322b07f3fc632
https://europepmc.org/articles/PMC1876895/

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