Discerning asthma endotypes through comorbidity mapping

Autor: Gengjie Jia, Xue Zhong, Hae Kyung Im, Nathan Schoettler, Milton Pividori, D. Kyle Hogarth, Anne I. Sperling, Steven R. White, Edward T. Naureckas, Christopher S. Lyttle, Chikashi Terao, Yoichiro Kamatani, Masato Akiyama, Koichi Matsuda, Michiaki Kubo, Nancy J. Cox, Carole Ober, Andrey Rzhetsky, Julian Solway

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Asthma is a heterogeneous, complex syndrome that arises in individuals with various genetic and exposure variations. Here, the authors show that disease comorbidity patterns can serve as a surrogate for these variations, and identify asthma endotypes

Externí odkaz: https://doaj.org/article/c0bc253f917a42f192232de999a0a2e9

A series of COVID‐19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza

Autor: Phillip McMullen, Peter Pytel, Alexis Snyder, Heather Smith, Jasmine Vickery, James Brainer, Robert Guzy, David Wu, Nathan Schoettler, Ayodeji Adegunsoye, Anne Sperling, John Hart, Lindsay Alpert, Anthony Chang, Sandeep Gurbuxani, Thomas Krausz, Aliya N Husain, Jeffrey Mueller

Publikováno v: The Journal of Pathology: Clinical Research, Vol 7, Iss 5, Pp 459-470 (2021)

Abstract Autopsies of patients who have died from COVID‐19 have been crucial in delineating patterns of injury associated with SARS‐CoV‐2 infection. Despite their utility, comprehensive autopsy studies are somewhat lacking relative to the globa

Externí odkaz: https://doaj.org/article/57fc9257ef47416bbb35391229da3920

Genetic and epigenetic links to asthma

Autor: Andréanne Morin, Carole Ober, Nathan Schoettler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a344b1d027a5ea8523ce576f4ca12b93
https://doi.org/10.1016/b978-0-323-85419-1.00003-7

SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy

Autor: Gökhan M. Mutlu, Ayodeji Adegunsoye, Yun Fang, Tzu-Han Lee, Robert D. Guzy, Aliya N. Husain, Nathan Schoettler, Anne I. Sperling, Ru-Ting Huang, David Wu, Jeffrey Mueller

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 65:222-226

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be0ee60961490565026fd2ffe52a4de7
https://doi.org/10.1165/rcmb.2020-0564le

Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

Autor: Carole Ober, Chris G McKennan, Kevin M Magnaye, Matthew C Altman, Charles Washington, Catherine Stanhope, Katherine A Naughton, Mario G Rosasco, Leonard B Bacharier, Dean Billheimer, Diane R Gold, Lisa Gress, Tina Hartert, Suzanne Havstad, Gurjit K Khurana Hershey, Brian Hallmark, D Kyle Hogarth, Daniel J Jackson, Christine C Johnson, Meyer Kattan, Robert F Lemanske, Susan V Lynch, Eneida A Mendonca, Rachel L Miller, Edward T Naureckas, George T O'Connor, Christine M Seroogy, Ganesa Wegienka, Steven R White, Robert A Wood, Anne L Wright, Edward M Zoratti, Fernando D Martinez, Dennis Ownby, Dan L Nicolae, Albert M Levin, James E Gern, Niek Achten, John Ainsworth, Nonna Akkerman, Elizabeth Anderson, Larry J. Anderson, Howard Andrews, Elizabeth Armagost, Mary Ann Aubuchon, Julia Bach, Leonard Bacharier, Kathrine L. Barnes, Charles Barone, Irma Bauer, Paloma Beamer, Patrice Becker, Alyssa Bednarek, Stacey Bellemore, Casper G. Bendixsen, Jocelyn M. Biagini Myers, Christine Billstrand, Geraldine Birg, Shirley Blocki, Gordon Bloomberg, Kevin Bobbitt, Yury Bochkov, Karen Bourgeois, Homer Boushey, Rebecca Brockman-Schneider, Steven M. Brunwasser, Richard Budrevich, Jeffrey W. Burkle, William Busse, Agustin Calatroni, Janice Campbell, Kirsten Carlson-Dakes, Andrea Cassidy-Bushrow, James D. Chappell, Deborah Chasman, Teresa M. Chipps, Tatiana Chirkova, Deanna Cole, Alexandra Connolly, Michelle Cootauco, Kaitlin Costello, Philip Couch, Brent Coull, Mark Craven, Gina Crisafi, William Cruikshank, Kristi Curtsinger, Adnan Custovic, Suman R. Das, Douglas DaSilva, Soma Datta, Brent Davidson, Lydia De La Ossa, Mark DeVries, Qian Di, Samara Dixon, Erin Donnerbauer, Marian Dorst, Susan Doyle, Amy Dresen, William D. Dupont, Janet Durrange, Heidi Erickson, Michael D. Evans, Jerel Ezell, Leanna Farnham, Roxanne Filardo-Collins, Salvatore Finazzo, Zachary Flege, Conner Fleurat, Heather Floerke, Dorothy Floerke, Terry Foss, Angela Freie, Wayne Frome, Samantha Fye, Lisa Gagalis, Rebecca Gammell, Ronald E. Gangnon, James E. Ge, Tebeb Gebretsadik, Peter Gergen, James E. Gern, Heike Gibson, Edlira Gjerasi, Diane R. Gold, Nicole Gonzalez, Kayla Goodman, Kristine Grindle, Taylor Groeschen, Marilyn Halonen, Jaime Hart, Tina V. Hartert, Patrick Heinritz, Sharon Hensley Alford, Julie Herbstman, Kellie Hernandez, Lori Hoepner, Daniel J. Jackson, Samadhan J. Jadhao, Katy Jaffee, Peter James, Jacqueline Jezioro, Marcia Jimenez Pescador, Christine C. Johnson, Tara Johnson, Camille Johnson, Amelia Jones, Kyra Jones, Paul Jones, Carolina Jordan, Christine LM Joseph, Kristina Keidel, Matthew C. Keifer, Rick Kelley, Gurgit K. Khurana Hershey, Haejin Kim, Itai Kloog, Tammy Kronenwetter Koepel, Clint Koerkenmeier, Laura Ladick, Carin Lamm, Emma Larkin, Howard Lederman, Aviva Lee-Parritz, Stephanie Leimenstoll, Robert F. Lemanske, Jr., Grace K. LeMasters, Albert M. Levin, Jessica Levine, Xinhua Liu, Zhouwen Liu, Silvia Lopez, Nathan Lothrop, Stephanie Lovinsky-Desir, Nicholas Lukacs, Susan Lynch, Christian Lynch, Erik Mann, Jennifer Martin, Lisa Martin, Fernando D. Martinez, Elizabeth Matsui, Katherine McCauley, Megan Mccollum, Judith McCullough, Chris G. McKennon, Jennifer Meece, Eneida Mendonca, Lance Mikus, Rachel L. Miller, Patricia Minton, Herman Mitchell, Vicki Moon, Paul E. Moore, Wayne Morgan, Valerie Morgan, David Morgan, Liza Murrison, Charlotte Nicholas, Daniel Nicolae, Adam Nunez, George O'Connor, Sharon O'Toole, Brent F. Olson, Irene Ong, Sarah Osmundson, Tressa Pappas, Frederica Perera, Matthew Perzanowski, Edward Peterson, Marcela Pierce, Penny Price-Johnson, Victoria Rajamanickam, Judyth Ramirez, Kimberly Ray, Megan Renneberg, Weeberb Requia, Kylie Riley, Janelle Rivera, Neisha Rivers, Kathy Roberg, Theresa Rogers, Christian Rosas-Salazar, Pat Russell, Patrick H. Ryan, Yoel Sadovsky, Lisa Salazar, Hugh Sampson, Megan Sandel, Nathan Schoettler, Joel Schwartz, Dena Scott, Christine M. Seroogy, Renee Sharp, Meghan H. Shilts, Steve Sigelman, Anne Marie Singh, Alexandra Sitarik, Ernestine Smartt, Ronald Sorkness, Christine Sorkness, Amber Spangenberg, Rhoda Sperling, David Spies, Debra A. Stern, Brandy Stoffel, R. Stokes Peebles, Gina Stouffer, Cathey Strauchman Boyer, Caitlin Suddeuth, Umberto Tachinardi, Deliang Tang, Zhengzheng Tang, Jena Tate, William Taylor, Krista Tensing, Elizabeth Tesson, Kathy Thompson, Emma Thompson, Christopher Tisler, Alkis Togias, Kedir Turi, Victoria Turner, Marina Tuzova, Jeffrey J. VanWormer, Cynthia M. Visness, Rose Vrtis, Anthony Wahlman, Lena Wang, Karen Wells, William Wentworth-Sheilds, Lisa Wheatley, Nitsa Whitney, L. Keoki Williams, Frank Witter, Christopher Wolfe, Robert A. Wood, Kimberley Woodcroft, Kim B. Woodward, Anne L. Wright, Rosalind Wright, Pingsheng Wu, Melissa Yaeger, Perri Yaniv, Antonella Zanobetti, Shirley Zhang, Patricia Zook, Edward M. Zoratti

Publikováno v: lancet. Respiratory medicine, 8(5), 482-492. Elsevier Limited

Background: African ancestry is associated with a higher prevalence and greater severity of asthma than European ancestries, yet genetic studies of the most common locus associated with childhood-onset asthma, 17q12–21, in African Americans have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7146468386db6c091b7e3aaef02926ed
http://www.scopus.com/inward/record.url?scp=85084083177&partnerID=8YFLogxK