Výsledky vyhledávání - "Nathan, Gumlaw"

Akademický článek

A bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetes.

Autor: Hongmei Zhao, Jozsef Karman, Ji-Lei Jiang, Jinhua Zhang, Nathan Gumlaw, John Lydon, Qun Zhou, Huawei Qiu, Canwen Jiang, Seng H Cheng, Yunxiang Zhu

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63530 (2013)

Crosslinking ligand-engaged cytotoxic T lymphocyte antigen-4 (CTLA-4) to the T cell receptor (TCR) with a bispecific fusion protein (BsB) comprised of a mutant mouse CD80 and lymphocyte activation antigen-3 (LAG-3) has been shown to attenuate TCR sig

Externí odkaz: https://doaj.org/article/4bc2461a64c84f2eb8cb8f2124dc291e

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Ligation of Cytotoxic T Lymphocyte Antigen-4 to T Cell Receptor Inhibits T Cell Activation and Directs Differentiation into Foxp3+ Regulatory T Cells

Autor: Nathan Gumlaw, Jose Sancho, Yunxiang Zhu, Canwen Jiang, Ji-Lei Jiang, Juanita Campos-Rivera, Hongmei Zhao, Seng H. Cheng, Jozsef Karman, Jinhua Zhang

Publikováno v: Journal of Biological Chemistry. 287:11098-11107

Cross-linking of ligand-engaged cytotoxic T lymphocyte antigen-4 (CTLA-4) to the T cell receptor (TCR) during the early phase of T cell activation attenuates TCR signaling, leading to T cell inhibition. To promote this event, a bispecific fusion prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833fc6b60b266bf888411842b03f2742
https://doi.org/10.1074/jbc.m111.283705

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Single Molecule Analysis of a Red Fluorescent RecA Protein Reveals a Defect in Nucleoprotein Filament Nucleation That Relates to Its Reduced Biological Functions

Autor: Ichiro Amitani, Nathan Gumlaw, Steven J. Sandler, Naofumi Handa, Stephen C. Kowalczykowski

Publikováno v: Journal of Biological Chemistry. 284:18664-18673

Fluorescent fusion proteins are exceedingly useful for monitoring protein localization in situ or visualizing protein behavior at the single molecule level. Unfortunately, some proteins are rendered inactive by the fusion. To circumvent this problem,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1368d9ccc311008fea8ea4866871813a
https://doi.org/10.1074/jbc.m109.004895

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Localization of RecA in Escherichia coli K-12 using RecA-GFP

Autor: Richard C. Centore, Steven J. Sandler, Edward Long, Nathan Gumlaw, Nicholas Renzette, Su-Ping Yeh, Marlee Krieger, Ruethairat Boonsombat, Jared T. Nordman

Publikováno v: Molecular Microbiology. 57:1074-1085

RecA is important in recombination, DNA repair and repair of replication forks. It functions through the production of a protein-DNA filament. To study the localization of RecA in live Escherichia coli cells, the RecA protein was fused to the green f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90c5e8f57320e3b504592dfaf79ae651
https://doi.org/10.1111/j.1365-2958.2005.04755.x

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Proteasome Inhibition Is Partially Effective in Attenuating Pre-Existing Immunity against Recombinant Adeno-Associated Viral Vectors

Autor: Jozsef Karman, Ji-Lei Jiang, Nathan Gumlaw, Jinhua Zhang, Yunxiang Zhu, Seng H. Cheng

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e34684 (2012)

Pre-existing immunity against adeno-associated virus (AAV) remains a major challenge facing the clinical use of systemic administration of recombinant AAV vectors for the treatment of genetic and acquired diseases using gene therapy. In this study, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf4700c8fb944e7e0a7d33ab8230974
http://europepmc.org/articles/PMC3326043

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Lowering Glycosphingolipid Levels in CD4+ T Cells Attenuates T Cell Receptor Signaling, Cytokine Production, and Differentiation to the Th17 Lineage*

Autor: Johanne Kaplan, Craig Siegel, Seng H. Cheng, Pete Maniatis, Wei-Lien Chuang, Nathan Gumlaw, Yunxiang Zhu, Canwen Jiang, Hongmei Zhao, Ji Lei Jiang, James A. Shayman, Jozsef Karman, Jinhua Zhang, Andrea Edling

Lipid rafts reportedly have a role in coalescing key signaling molecules into the immunological synapse during T cell activation, thereby modulating T cell receptor (TCR) signaling activity. Recent findings suggest that a correlation may exist betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f860e80008486541fafd33304aed3bd2
https://europepmc.org/articles/PMC3083190/

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Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma

Autor: Yunxiang Zhu, Jozsef Karman, Andrew M. Siwkowski, Seng H. Cheng, Nathan Gumlaw, Nelson S. Yew, Jennifer Tedstone, Melanie Ruzek, Craig Siegel, Shuling Guo, Canwen Jiang

Publikováno v: International immunology. 22(7)

Lipid rafts reportedly play an important role in modulating the activation of mast cells and granulocytes, the primary effector cells of airway hyperresponsiveness and asthma. Activation is mediated through resident signaling molecules whose activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0c7beebf2c39954aaf5544bfe3d82a
https://pubmed.ncbi.nlm.nih.gov/20497953

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Glycoengineered acid alpha-glucosidase with improved efficacy at correcting the metabolic aberrations and motor function deficits in a mouse model of Pompe disease

Autor: Scott D. Bercury, Robin J. Ziegler, Mariko Kudo, Robert J. Mattaliano, Canwen Jiang, Seng H. Cheng, Jinhua Zhang, Ji-Lei Jiang, Nathan Gumlaw, William M. Canfield, Karen Lee, Yunxiang Zhu, Tim Edmunds

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 17(6)

Improving the delivery of therapeutics to disease-affected tissues can increase their efficacy and safety. Here, we show that chemical conjugation of a synthetic oligosaccharide harboring mannose 6-phosphate (M6P) residues onto recombinant human acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d467d2053b2922c9dc1b5110db09615e
https://pubmed.ncbi.nlm.nih.gov/19277015

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DinI and RecX modulate RecA-DNA structures in Escherichia coli K-12

Autor: Steven J. Sandler, Nathan Gumlaw, Nicholas Renzette

Publikováno v: Molecular microbiology. 63(1)

Summary RecA plays a central role in recombination, DNA repair and SOS induction through forming a RecA- DNA helical filament. Biochemical observations show that at low ratios to RecA, DinI and RecX stabilize and destabilize RecA-DNA filaments, respe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ef5ecd19e3b290cb98bbe4dbe0532a
https://pubmed.ncbi.nlm.nih.gov/17163974

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Localization of RecA in Escherichia coli K-12 using RecA-GFP

Autor: Nicholas, Renzette, Nathan, Gumlaw, Jared T, Nordman, Marlee, Krieger, Su-Ping, Yeh, Edward, Long, Richard, Centore, Ruethairat, Boonsombat, Steven J, Sandler

Publikováno v: Molecular microbiology. 57(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac2c8d43057798e2507347d3f8ce3c2b
https://pubmed.ncbi.nlm.nih.gov/16091045

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