Výsledky vyhledávání - "Nathalie van Leeuwen-Kerkhoff"

Akademický článek

The immunoregulatory role of monocytes and thrombomodulin in myelodysplastic neoplasms

Autor: Luca L. G. Janssen, Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Tanja D. de Gruijl, Arjan A. van de Loosdrecht

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

Myelodysplastic neoplasms (MDS) are clonal disorders of the myeloid lineage leading to peripheral blood cytopenias. Dysregulation of innate immunity is hypothesized to be a potent driver of MDS. A recent study revealed increased thrombomodulin (TM) e

Externí odkaz: https://doaj.org/article/3383244b3918458eac67d76f64cdbe5e

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Akademický článek

Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes

Autor: Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Giovanni A.M. Povoleri, Jessica A. Timms, Shahram Kordasti, Tanja D. de Gruijl, Arjan A. van de Loosdrecht

Publikováno v: Haematologica, Vol 107, Iss 3 (2021)

In myelodysplastic syndromes (MDS) the immune system is involved in pathogenesis as well as in disease progression. Dendritic cells (DC) are key players of the immune system by serving as regulators of immune responses. Their function has been scarce

Externí odkaz: https://doaj.org/article/26f1528540ce4db4a14df7d35edc7962

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Akademický článek

Thrombomodulin-expressing monocytes are associated with low-risk features in myelodysplastic syndromes and dampen excessive immune activation

Autor: Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Tanja D. de Gruijl, Shahram Kordasti, Arjan A. van de Loosdrecht

Publikováno v: Haematologica, Vol 105, Iss 4 (2020)

The bone marrow of patients with low-risk myelodysplastic syndromes (MDS) is often an inflammatory environment and associated with an active cellular immune response. An active immune response generally contributes to antitumor responses and may prev

Externí odkaz: https://doaj.org/article/ce1bc9bd25e44a2e8185f575615a02f2

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Akademický článek

Human Bone Marrow-Derived Myeloid Dendritic Cells Show an Immature Transcriptional and Functional Profile Compared to Their Peripheral Blood Counterparts and Separate from Slan+ Non-Classical Monocytes

Autor: Nathalie van Leeuwen-Kerkhoff, Kristina Lundberg, Theresia M. Westers, Shahram Kordasti, Hetty J. Bontkes, Malin Lindstedt, Tanja D. de Gruijl, Arjan A. van de Loosdrecht

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However

Externí odkaz: https://doaj.org/article/2034071a8c0544be8caa41d6334e7a30

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Case report

Autor: Nathalie van Leeuwen‐Kerkhoff, Moniek A. de Witte, Marloes W. Heijstek, Helen L. Leavis

Publikováno v: van Leeuwen-Kerkhoff, N, de Witte, M A, Heijstek, M W & Leavis, H L 2022, ' Case report : Up-front allogeneic stem cell transplantation in a patient with the VEXAS syndrome ', British Journal of Haematology, vol. 199, no. 3, pp. e12-e15 . https://doi.org/10.1111/bjh.18424
British Journal of Haematology, 199(3), e12-e15. Wiley-Blackwell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f708311e5472ffa2c0c4455431ed304
http://www.scopus.com/inward/record.url?scp=85136866805&partnerID=8YFLogxK

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Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes

Autor: Nathalie van Leeuwen-Kerkhoff, Shahram Kordasti, Theresia M. Westers, Giovanni A M Povoleri, Tanja D. de Gruijl, Pino J Poddighe, Arjan A. van de Loosdrecht, Jessica A Timms

Publikováno v: Haematologica, 107(3), 655-667. Ferrata Storti Foundation
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, Povoleri, G A M, Timms, J A, Kordasti, S, de Gruijl, T D & van de Loosdrecht, A A 2022, ' Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes ', Haematologica, vol. 107, no. 3, pp. 655-667 . https://doi.org/10.3324/haematol.2020.268136

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5391dba937cb802184434c01c08a37
https://research.vumc.nl/en/publications/db725181-9627-4bb8-b6d6-30678dae82ff

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Thrombomodulin-expressing monocytes are associated with low-risk features in myelodysplastic syndromes and dampen excessive immune activation

Autor: Arjan A. van de Loosdrecht, Tanja D. de Gruijl, Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Shahram Kordasti

Publikováno v: Haematologica
van Leeuwen-Kerkhoff, N, Westers, T M, Poddighe, P J, de Gruijl, T D, Kordasti, S & van de Loosdrecht, A A 2020, ' Thrombomodulin expressing monocytes are associated with low risk features in myelodysplastic syndromes and dampen excessive immune activation ', Haematologica, vol. 105, no. 4, pp. 961-970 . https://doi.org/10.3324/haematol.2019.219303
Haematologica, 105(4), 961-970. Ferrata Storti Foundation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38295e19a7b543e5b087a071eab3af9c
http://europepmc.org/articles/PMC7109736

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Autor: Kristina Lundberg, Shahram Kordasti, Nathalie van Leeuwen-Kerkhoff, Tanja D. de Gruijl, Arjan A. van de Loosdrecht, Malin Lindstedt, Hetty J. Bontkes, Theresia M. Westers

Publikováno v: Frontiers in Immunology
van Leeuwen-Kerkhoff, N, Lundberg, K, Westers, TM, Kordasti, S, Bontkes, HJ, Lindstedt, M, de Gruijl, TD & van de Loosdrecht, AA 2018, ' Human Bone Marrow-Derived Myeloid Dendritic Cells Show an Immature Transcriptional and Functional Profile Compared to Their Peripheral Blood Counterparts and Separate from Slan+ Non-Classical Monocytes ', Frontiers in Immunology, vol. 9, no. 1619 . https://doi.org/10.3389/fimmu.2018.01619
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 9(1619). Frontiers Media S.A.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18947a816cc7bfa910a97090194d220
http://europepmc.org/articles/PMC6055354

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Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells

Autor: Tanja D. de Gruijl, Theresia M. Westers, Malin Lindstedt, Kristina Lundberg, Arjan A. van de Loosdrecht, Shahram Kordasti, Hetty J. Bontkes, Nathalie van Leeuwen-Kerkhoff

Publikováno v: van Leeuwen-Kerkhoff, N, Lundberg, K, Westers, T M, Kordasti, S, Bontkes, H J, de Gruijl, T D, Lindstedt, M & van de Loosdrecht, A A 2017, ' Transcriptional profiling reveals functional dichotomy between human slan + non-classical monocytes and myeloid dendritic cells ', Journal of Leukocyte Biology, vol. 102, no. 4, pp. 1055-1068 . https://doi.org/10.1189/jlb.3MA0117-037R
Journal of Leukocyte Biology, 102(4), 1055-1068. FASEB

Human 6-sulfo LacNac-positive (slan+) cells have been subject to a paradigm debate. They have previously been classified as a distinct dendritic cell (DC) subset. However, evidence has emerged that they may be more related to monocytes than to DCs. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cc365d54d0dd0ac24aeb58f3b0a675
https://research.vumc.nl/en/publications/c4623abe-0cb6-45e2-9bd4-6323c053641d

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