Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Autor: Bas B. Oude Munnink, Roel H.T. Nijhuis, Nathalie Worp, Marjan Boter, Babette Weller, Babs E. Verstrepen, Corine GeurtsvanKessel, Maarten L. Corsten, Anne Russcher, Marion Koopmans

Publikováno v: Emerging Infectious Diseases, Vol 28, Iss 9, Pp 1920-1923 (2022)

We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and dis

Externí odkaz: https://doaj.org/article/0b7d7093a5db4db98222c58b8a494aeb

Microcalorimetry: A Novel Application to Measure In Vitro Phage Susceptibility of Staphylococcus aureus in Human Serum

Autor: Michèle M. Molendijk, My V. T. Phan, Lonneke G. M. Bode, Nikolas Strepis, Divyae K. Prasad, Nathalie Worp, David F. Nieuwenhuijse, Claudia M. E. Schapendonk, Bouke K. H. L. Boekema, Annelies Verbon, Marion P. G. Koopmans, Miranda de Graaf, Willem J. B. van Wamel

Publikováno v: Viruses, 15(1):14. Multidisciplinary Digital Publishing Institute (MDPI)
Viruses; Volume 15; Issue 1; Pages: 14

Infections involving antibiotic resistant Staphylococcus aureus (S. aureus) represent a major challenge to successful treatment. Further, although bacteriophages (phages) could be an alternative to antibiotics, there exists a lack of correlation in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ea355b8904e27ffe093f43a9195668
https://pure.eur.nl/en/publications/a51ac33d-9325-4bd8-a680-fc55077b68ed

An early warning system for emerging SARS-CoV-2 variants

Autor: Lorenzo Subissi, Anne von Gottberg, Lipi Thukral, Nathalie Worp, Bas B. Oude Munnink, Surabhi Rathore, Laith J. Abu-Raddad, Ximena Aguilera, Erik Alm, Brett N. Archer, Homa Attar Cohen, Amal Barakat, Wendy S. Barclay, Jinal N. Bhiman, Leon Caly, Meera Chand, Mark Chen, Ann Cullinane, Tulio de Oliveira, Christian Drosten, Julian Druce, Paul Effler, Ihab El Masry, Adama Faye, Simani Gaseitsiwe, Elodie Ghedin, Rebecca Grant, Bart L. Haagmans, Belinda L. Herring, Shilpa S. Iyer, Zyleen Kassamali, Manish Kakkar, Rebecca J. Kondor, Juliana A. Leite, Yee-Sin Leo, Gabriel M. Leung, Marco Marklewitz, Sikhulile Moyo, Jairo Mendez-Rico, Nada M. Melhem, Vincent Munster, Karen Nahapetyan, Djin-Ye Oh, Boris I. Pavlin, Thomas P. Peacock, Malik Peiris, Zhibin Peng, Leo L. M. Poon, Andrew Rambaut, Jilian Sacks, Yinzhong Shen, Marilda M. Siqueira, Sofonias K. Tessema, Erik M. Volz, Volker Thiel, Sylvie van der Werf, Sylvie Briand, Mark D. Perkins, Maria D. Van Kerkhove, Marion P. G. Koopmans, Anurag Agrawal

Publikováno v: Nature Medicine
Nature Medicine, 2022, 28 (6), pp.1110-1115. ⟨10.1038/s41591-022-01836-w⟩
Nature Medicine, 28(6), 1110-1115. Nature Publishing Group

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301b16846e7ffa38ab66d475410b1270
https://hal-pasteur.archives-ouvertes.fr/pasteur-04098063

Correction to Resolving Chemical Modifications to a Single Amino Acid within a Peptide Using a Biological Nanopore

Autor: Giovanni Maglia, Rienk Eelkema, Cees Dekker, Gang Huang, Chirlmin Joo, Nathalie Worp, Laura Restrepo-Pérez, Peggy R. Bohländer

Publikováno v: ACS Nano

While DNA sequencing is now amply available, fast, and inexpensive, protein sequencing remains a tremendous challenge. Nanopores may allow for developing a protein sequencer with single-molecule capabilities. As identification of 20 different amino a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c7eb066b1ef2486b1d085f61e47e96
https://doi.org/10.1021/acsnano.0c01699

GPCRmd uncovers the dynamics of the 3D-GPCRome

Autor: Minos-Timotheos Matsoukas, David E. Gloriam, Ismael Rodríguez-Espigares, Agnieszka Sztyler, Davide Provasi, Arnau Cordomí, Peter Kolb, David Aranda-García, Toni Giorgino, Ferran Sanz, Mariona Torrens-Fontanals, Peter W. Hildebrand, Maria Marti-Solano, Mireia Olivella, Alejandro Varela-Rial, Gianni De Fabritiis, José Carlos Gómez-Tamayo, Laura Pérez-Benito, Tomasz Maciej Stepniewski, Eduardo Mayol, Silvana Vasile, Slawomir Filipek, Ulrich Zachariae, Jens Carlsson, Dorota Latek, Harel Weinstein, Gáspár Pándy-Szekeres, Przemyslaw Miszta, Willem Jespers, Nathalie Worp, Mireia Jiménez-Rosés, Juan Manuel Ramírez-Anguita, Marta Filizola, George Khelashvili, Angel Gonzalez, Brian Medel Lacruz, Pierre Matricon, Iván Rodríguez-Torrecillas, Xavier Deupi, Adrián Morales-Pastor, Jessica Sallander, Hugo Gutiérrez-de-Terán, Johanna K. S. Tiemann, Jana Selent, Jon Kapla, Ramon Guixà-González, Santiago Ríos

Publikováno v: Nature Methods
Nature methods (Online) 17 (2020): 777–787. doi:10.1038/s41592-020-0884-y
info:cnr-pdr/source/autori:Rodríguez-Espigares, Ismael; Torrens-Fontanals, Mariona; Tiemann, Johanna K.S.; Aranda-García, David; Ramírez-Anguita, Juan Manuel; Stepniewski, Tomasz Maciej; Worp, Nathalie; Varela-Rial, Alejandro; Morales-Pastor, Adrián; Medel-Lacruz, Brian; Pándy-Szekeres, Gáspár; Mayol, Eduardo; Giorgino, Toni; Carlsson, Jens; Deupi, Xavier; Filipek, Slawomir; Filizola, Marta; Gómez-Tamayo, José Carlos; Gonzalez, Angel; Gutiérrez-de-Terán, Hugo; Jiménez-Rosés, Mireia; Jespers, Willem; Kapla, Jon; Khelashvili, George; Kolb, Peter; Latek, Dorota; Marti-Solano, Maria; Matricon, Pierre; Matsoukas, Minos Timotheos; Miszta, Przemyslaw; Olivella, Mireia; Perez-Benito, Laura; Provasi, Davide; Ríos, Santiago; R. Torrecillas, Iván; Sallander, Jessica; Sztyler, Agnieszka; Vasile, Silvana; Weinstein, Harel; Zachariae, Ulrich; Hildebrand, Peter W.; De Fabritiis, Gianni; Sanz, Ferran; Gloriam, David E.; Cordomi, Arnau; Guixà-González, Ramon; Selent, Jana/titolo:GPCRmd uncovers the dynamics of the 3D-GPCRome/doi:10.1038%2Fs41592-020-0884-y/rivista:Nature methods (Online)/anno:2020/pagina_da:777/pagina_a:787/intervallo_pagine:777–787/volume:17

G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes and are the most frequent targets of approved drugs. The explosion in the number of new three-dimensional (3D) molecular structures of GPCRs (3D-GPCRome) over the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb6367e2808eb6eb81235f76f7853ad