Addition of Electrophilic Radicals to 2-Benzyloxyglycals: Synthesis and Functionalization of Fluorinated α-C-Glycosides and Derivatives

Autor: Xavier Pannecoucke, Nathalie Van Hijfte, Thomas Poisson, Sophie Colombel, Eric Leclerc

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2013, 19 (38), pp.12778-12787. ⟨10.1002/chem.201302070⟩

International audience; A new method for the synthesis of fluorinated α-C-glycosides is described. The reactions between highly electrophilic radicals (fluorinated or unfluorinated) and a 2-benzyloxyglucal or galactal provide 2-keto-D-arabino- or 2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fdfb28fce60b6f9abaff0a5cba2207
https://doi.org/10.1002/chem.201302070

Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors

Autor: Fanny Gassiot, Bénédicte Daydé-Cazals, Abdelaziz Yasri, Aurélia Spenlinhauer, Nozha Borjini, Pierre Warnault, Gwénaël Chevé, Nathalie Van Hijfte, Mathilde Singer, Benoit Bestgen, Bénédicte Fauvel, Clémence Feneyrolles

Publikováno v: Journal of medicinal chemistry. 59(8)

Efforts were made to improve a series of potent dual ABL/SRC inhibitors based on a 7-azaindole core with the aim of developing compounds that demonstrate a wider activity on selected oncogenic kinases. Multi-targeted kinase inhibitors (MTKIs) were th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e6babf75db64f165d1500fae2d7431
https://pubmed.ncbi.nlm.nih.gov/27010810

ChemInform Abstract: Indium-Promoted Diastereoselective Addition of Fluorinated Haloallylic Derivatives to Imines

Autor: Gérald Lemonnier, Nathalie Van Hijfte, Xavier Pannecoucke, Thomas Poisson, Samuel Couve-Bonnaire

Publikováno v: ChemInform. 45

We report herein the first general access to fluorinated homoallylic amines by means of an addition of fluorinated organoindium reagent. The corresponding amines were obtained in good to excellent yield with excellent diastereoisomeric ratio. A plaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32954a62229c40ff91b7fbe06dd099bb
https://doi.org/10.1002/chin.201442049

Recent progress in the design, study, and development of c-Jun N-terminal kinase inhibitors as anticancer agents

Autor: Nathalie Van Hijfte, Aurélie Bros, Bénédicte Fauvel, Arthur Deroide, Aziz Yasri, Khalid Bougrin, Clémence Feneyrolles, Gwénaël Chevé, Abdellah Messoussi, Bénédicte Daydé-Cazals

Publikováno v: Chemistrybiology. 21(11)

The c-Jun N-terminal kinase (JNK) family, with its three members JNK1, JNK2, and JNK3, is a subfamily of mitogen-activated protein kinases. Involved in many aspects of cellular processes, JNK has been also associated with pathological states such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afe5e291c4aef445016d2ea365b2d92
https://pubmed.ncbi.nlm.nih.gov/25442375

Eaton's reagent-mediated domino π-cationic arylations of aromatic carboxylic acids to Iasi-red polymethoxylated polycyclic aromatic hydrocarbons: products with unprecedented biological activities as tubulin polymerization inhibitors

Autor: Alina Ghinet, Adam Daïch, Ulrich Darbost, Nathalie Van Hijfte, Benoît Rigo, Bertrand Lede, Jean‐Pierre Henichart, Philippe Gautret, Elena Bîcu

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (32), pp.10117-10130. ⟨10.1002/chem.201402377⟩
Chemistry-A European Journal, 2014, 20 (32), pp.10117-10130. ⟨10.1002/chem.201402377⟩

International audience; A rapid domino π-cationic arylation of aromatic carboxylic acids, mediated by Eaton's reagent, has been developed for the synthesis of Iasi-red polymethoxylated polycyclic aromatic hydrocarbons (PAHs). This route is currently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a03a549ae4eb4d3b3208d56d70f16c
https://pubmed.ncbi.nlm.nih.gov/25042333