Výsledky vyhledávání - "Nathalie Touchet"

Akademický článek

Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice

Autor: Anne Eckert, Katharina Schindowski, Silke Leutner, Christian Luckhaus, Nathalie Touchet, Christian Czech, Walter E. Müller

Publikováno v: Neurobiology of Disease, Vol 8, Iss 2, Pp 331-342 (2001)

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell

Externí odkaz: https://doaj.org/article/a997bd3402fe4b9b91e6a231ee2cdc38

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Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in β-amyloid load

Autor: Charles Duyckaerts, Laurent Pradier, Nathalie Touchet, Luc Mercken, Nicolas Sergeant, André Delacourte, Gunter Tremp, Dominique Santiard-Baron, Dominique Langui, Benoît Delatour, Véronique Blanchard, Brigitte Schombert, Maryse Delehedde, Marie-Françoise Paul

Publikováno v: Journal of Neurochemistry. 93:330-338

FE65 is an adaptor protein that interacts with the cytoplasmic tail of the amyloid precursor protein (APP). In cultured non-neuronal cells, the formation of the FE65-APP complex is a key element for the modulation of APP processing, signalling and be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d10d9748debebe820bedaac9aef76df
https://doi.org/10.1111/j.1471-4159.2005.03026.x

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Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1

Autor: Jean Pierre Brion, Gunter Tremp, Nathalie Touchet, Laurent Pradier, Allal Boutajangout, Véronique Blanchard, Michèle Authelet

Publikováno v: Neurobiology of Disease, Vol 15, Iss 1, Pp 47-60 (2004)

To study the role of Abeta amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R), a mutant form of APP (751SL) and a mutant form of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2fdb6651445bb1641022cf88e81888
https://doi.org/10.1016/j.nbd.2003.09.007

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Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice

Autor: Laurent Pradier, Micheline Gohin, Thomas A. Bayer, Dominique Langui, Christian Czech, Véronique Blanchard, Charles Duyckaerts, Thierry Canton, Nathalie Touchet, Michel Planche, Saliha Moussaoui, Gunter Tremp, Oliver Wirths, Bruno Bonici, Iness Jedidi

Publikováno v: Experimental Neurology. 184:247-263

Several novel transgenic mouse models expressing different mutant APPs in combination with mutant PS1 have been developed. These models have been analyzed to investigate the formation and progressive alterations of dystrophic neurites (DNs) in relati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6077054157ec6976baabbd4ace241274
https://doi.org/10.1016/s0014-4886(03)00252-8

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Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress

Autor: Jacques Hugon, Gunter Tremp, Catherine Yardin, Laurent Pradier, Françoise Esclaire, Marie-Claire Baclet, Faraj Terro, Nathalie Touchet, Wassim Elyaman, Christian Czech

Publikováno v: Journal of Neuroscience Research. 69:530-539

Most early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations in two related genes, ps1 and ps2. FAD-linked mutant PS1 alters proteolytic processing of the amyloid precursor protein and increases vulnerability to apoptosis indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2657d88b934bdea02061a375be9b27b
https://doi.org/10.1002/jnr.10312

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Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1

Autor: Jean Pierre Brion, Laurent Pradier, Michèle Authelet, Allal Boutajangout, Nathalie Touchet, Véronique Blanchard, Karelle Leroy, Gunter Tremp

Publikováno v: Neuroscience Letters. 318:29-33

Neurofibrillary tangles, composed of tau proteins, are a key lesion observed in sporadic forms of Alzheimer's disease and in familial forms associated with mutations of presenilin-1 (PS1). We have generated a double transgenic mouse line expressing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4183a569f8f568b2d679dc2c55cd90c4
https://doi.org/10.1016/s0304-3940(01)02461-2

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Proteolytical processing of mutated human amyloid precursor protein in transgenic mice

Autor: Martine Mazadier, Michel Reibaud, Luc Mercken, Pia Delaere, Nathalie Touchet, Sylvie Dreisler, Gunter Tremp, Laurent Pradier, Manfred Theisen, Christian Czech, Anne Francoise Macq, Brigitte Schombert, Jean-Noël Octave, Konrad Beyreuther

Publikováno v: Molecular Brain Research. 47:108-116

The evidence that betaA4 is central to the pathology of Alzheimer's disease (AD) came from the identification of several missense mutations in the amyloid precursor protein (APP) gene co-segregating with familial AD (FAD). In an attempt to study the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8b790eeb3d4465d78b51804c5a4d01
https://doi.org/10.1016/s0169-328x(97)00039-9

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Expression of human FE65 in Amyloid Precursor Protein transgenic mice is associated with a reduction in beta-Amyloid load

Autor: Dominique, Santiard-Baron, Dominique, Langui, Maryse, Delehedde, Benoît, Delatour, Brigitte, Schombert, Nathalie, Touchet, Günter, Tremp, Marie-Françoise, Paul, Véronique, Blanchard, Nicolas, Sergeant, André, Delacourte, Charles, Duyckaerts, Laurent, Pradier, Luc, Mercken

Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2005, 93 (2), pp.330-8. ⟨10.1111/j.1471-4159.2005.03026.x⟩

International audience; FE65 is an adaptor protein that interacts with the cytoplasmic tail of the amyloid precursor protein (APP). In cultured non-neuronal cells, the formation of the FE65-APP complex is a key element for the modulation of APP proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::df336c40f6bdc94015305fe315ae694f
https://hal.archives-ouvertes.fr/hal-00173286

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Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations

Autor: Walter E. Müller, Christian Czech, Silke Leutner, Katharina Schindowski, Nathalie Touchet, Anne Eckert

Publikováno v: Neuroscience letters. 292(2)

Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress. Here, we provide in vivo evidence indicating that brains of tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4acb3389569dad7b3080680470f5a48
https://pubmed.ncbi.nlm.nih.gov/10998555

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