Výsledky vyhledávání - "Nathalie Tombo"

Akademický článek

Mitofilin Heterozygote Mice Display an Increase in Myocardial Injury and Inflammation after Ischemia/Reperfusion

Autor: Yansheng Feng, Abdulhafiz Imam Aliagan, Nathalie Tombo, Jean C. Bopassa

Publikováno v: Antioxidants, Vol 12, Iss 4, p 921 (2023)

Mitochondrial inner membrane protein (Mitofilin/Mic60) is part of a big complex that constituent the mitochondrial inner membrane organizing system (MINOS), which plays a critical role in maintaining mitochondrial architecture and function. We recent

Externí odkaz: https://doaj.org/article/750e8e155a6b48a09966e3f1f8922668

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Akademický článek

RIP3 Translocation into Mitochondria Promotes Mitofilin Degradation to Increase Inflammation and Kidney Injury after Renal Ischemia–Reperfusion

Autor: Yansheng Feng, Abdulhafiz Imam Aliagan, Nathalie Tombo, Derrick Draeger, Jean C. Bopassa

Publikováno v: Cells, Vol 11, Iss 12, p 1894 (2022)

The receptor-interacting protein kinase 3 (RIP3) has been reported to regulate programmed necrosis–necroptosis forms of cell death with important functions in inflammation. We investigated whether RIP3 translocates into mitochondria in response to

Externí odkaz: https://doaj.org/article/bf37a7d28cd542819f49946d903c400e

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Akademický článek

Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway

Autor: Abdulhafiz Imam Aliagan, Ngonidzashe B. Madungwe, Nathalie Tombo, Yansheng Feng, Jean C. Bopassa

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

Introduction: Estrogen (17β-estradiol, E2) is well-known to induce cardioprotective effects against ischemia/reperfusion (I/R) injury. We recently reported that acute application of E2 at the onset of reperfusion in vivo induces cardioprotective eff

Externí odkaz: https://doaj.org/article/ec8651b3c30c42fdba95c2a004716173

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Cardiac ischemia/reperfusion stress reduces inner mitochondrial membrane protein (mitofilin) levels during early reperfusion

Autor: Yansheng Feng, Nathalie Tombo, Abdulhafiz Imam Aliagan, Jean C. Bopassa, Harpreet Singh

Publikováno v: Free Radic Biol Med

Mitochondrial inner membrane protein (Mitofilin or Mic60) is a mitochondria-shaping protein that plays a key role in maintaining mitochondrial cristae structure and remodeling. We recently showed that Mitofilin knockdown in H9c2 myoblasts induces mit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860ee8286b5196b5f39404c5ab8d00df
https://doi.org/10.1016/j.freeradbiomed.2020.06.039

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Autor: Ngonidzashe B Madungwe, Yansheng Feng, Jean C. Bopassa, Nathalie Tombo, Abdulhafiz Imam Aliagan

Publikováno v: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7818a1fb9a0156eb339abae00693403d
https://pubmed.ncbi.nlm.nih.gov/33193095

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Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

Autor: Yansheng Feng, Nathalie Tombo, Ngonidzashe B. Madungwe, Abdulhafiz Imam Aliagan, Jean C. Bopassa

Publikováno v: Biochem Biophys Res Commun

Ferroptosis is a distinct iron-dependent mechanism of regulated cell death recognized in cancer and ischemia/reperfusion (I/R) injury of different organs. It has been reported that molecules such as liproxstatin-1 (Lip-1) inhibit ferroptosis and prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5974a2ea36e3f61d9c74296f02118d96
https://pubmed.ncbi.nlm.nih.gov/31623831

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Abstract 162: Liproxstatin-1 Treatment Protects the Myocardium Against I-R Injury By Decreasing VDAC1 Levels and Increasing GPX4 Activity

Autor: Li Liu, Yansheng Feng, Abdulhafiz Imam Aliagan, Nathalie Tombo, Ngonidzashe B. Madungwe, Jean C. Bopassa

Publikováno v: Circulation Research. 125

Introduction: Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS) and liproxstatin-1 is a potent inhibitor of ferroptosis. We investigated whether Liproxstatin-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acb720ef17d9a88313bcea893f8490d2
https://doi.org/10.1161/res.125.suppl_1.162

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Mitochondrial inner membrane protein (mitofilin) knockdown induces cell death by apoptosis via an AIF-PARP-dependent mechanism and cell cycle arrest

Autor: Yansheng Feng, Mihaela Lie, Li Liu, Nathalie Tombo, Ferdinand Kaya, Jean C. Bopassa, Ngonidzashe B. Madungwe

Mitofilin is an inner membrane protein that has been defined as a mitochondria-shaping protein in controlling and maintaining mitochondrial cristae structure and remodeling. We determined the role of mitofilin in cell survival by investigating the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b41199549a76ef253d68a082124891
https://europepmc.org/articles/PMC6087732/

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