Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Nathalie Théret"'
Autor:
Matthieu Bouguéon, Vincent Legagneux, Octave Hazard, Jérémy Bomo, Anne Siegel, Jérôme Feret, Nathalie Théret
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1011858 (2024)
Hepatic stellate cells (HSC) are the source of extracellular matrix (ECM) whose overproduction leads to fibrosis, a condition that impairs liver functions in chronic liver diseases. Understanding the dynamics of HSCs will provide insights needed to d
Externí odkaz:
https://doaj.org/article/4e8d8be507604fb5b0fd775570547d7c
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011404 (2023)
Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families. Here we propose
Externí odkaz:
https://doaj.org/article/9c1a1b04859040578efcd3e7f2373bb1
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background The liver plays a major role in the metabolic activation of xenobiotics (drugs, chemicals such as pollutants, pesticides, food additives...). Among environmental contaminants of concern, heterocyclic aromatic amines (HAA) are xeno
Externí odkaz:
https://doaj.org/article/cf66101bd722434a88b86199a73f7f2c
Autor:
Ines Malenica, Julien Adam, Stéphanie Corgnac, Laura Mezquita, Edouard Auclin, Isabelle Damei, Laetitia Grynszpan, Gwendoline Gros, Vincent de Montpréville, David Planchard, Nathalie Théret, Benjamin Besse, Fathia Mami-Chouaib
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Response to PD-1 checkpoint blockade is unpredictable in lung cancer patients. Here authors show in human lung and mouse tumour models that low or absent αV integrin expression leads to better tumour growth control by anti-PD-1 via reduced TGF-β ac
Externí odkaz:
https://doaj.org/article/9f76efab27fb4f01b8031919754f4805
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010175 (2022)
Most biological processes are orchestrated by large-scale molecular networks which are described in large-scale model repositories and whose dynamics are extremely complex. An observed phenotype is a state of this system that results from control mec
Externí odkaz:
https://doaj.org/article/52918137ace746518787c7d819c32802
Autor:
Maxime Folschette, Vincent Legagneux, Arnaud Poret, Lokmane Chebouba, Carito Guziolowski, Nathalie Théret
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Integrating genome-wide gene expression patient profiles with regulatory knowledge is a challenging task because of the inherent heterogeneity, noise and incompleteness of biological data. From the computational side, several solv
Externí odkaz:
https://doaj.org/article/8853508052934fa38cea3be7db971abe
Publikováno v:
PeerJ, Vol 5, p e3703 (2017)
Background Heterocyclic aromatic amines (HAA) are environmental and food contaminants that are potentially carcinogenic for humans. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is one of the most abundant HAA formed in cooked meat. MeIQx is
Externí odkaz:
https://doaj.org/article/2e33bced6fd844688122062d3be3f150
Autor:
Michaël Ruff, Anthony Leyme, Fabienne Le Cann, Dominique Bonnier, Jacques Le Seyec, Franck Chesnel, Laurent Fattet, Ruth Rimokh, Georges Baffet, Nathalie Théret
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139179 (2015)
The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated with human cancers, however its role remain unclear. We have previously reported that ADAM12 expression is induced by the transforming growth factor, TGF-β an
Externí odkaz:
https://doaj.org/article/32d2e83f62bd4946a600658760f68a72
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33761 (2012)
TIF1γ (Transcriptional Intermediary Factor 1 γ) has been implicated in Smad-dependent signaling by Transforming Growth Factor beta (TGF-β). Paradoxically, TIF1γ functions both as a transcriptional repressor or as an alternative transcription fact
Externí odkaz:
https://doaj.org/article/a60aac4bd0944f2e973767004d21009c
Autor:
David Gilot, Nolwenn Le Meur, Fanny Giudicelli, Marc Le Vée, Dominique Lagadic-Gossmann, Nathalie Théret, Olivier Fardel
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18261 (2011)
The aryl hydrocarbon receptor (AhR) is a transcription factor activated by several environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and involved in carcinogenesis and various physiological processes, including immune resp
Externí odkaz:
https://doaj.org/article/d9020e2943854eb18e0c9d2d57c856d3