Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Nathalie Schnetz"'
Autor:
Molly A Hall, Anurag Verma, Kristin D Brown-Gentry, Robert Goodloe, Jonathan Boston, Sarah Wilson, Bob McClellan, Cara Sutcliffe, Holly H Dilks, Nila B Gillani, Hailing Jin, Ping Mayo, Melissa Allen, Nathalie Schnetz-Boutaud, Dana C Crawford, Marylyn D Ritchie, Sarah A Pendergrass
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004678 (2014)
We performed a Phenome-wide association study (PheWAS) utilizing diverse genotypic and phenotypic data existing across multiple populations in the National Health and Nutrition Examination Surveys (NHANES), conducted by the Centers for Disease Contro
Externí odkaz:
https://doaj.org/article/853bca80253e4e2ab6be28f5b1f52594
Autor:
Deborah G Murdock, Yuki Bradford, Nathalie Schnetz-Boutaud, Ping Mayo, Melissa J Allen, Laura N D'Aoust, Xueying Liang, Sabrina L Mitchell, Stephan Zuchner, Gary W Small, John R Gilbert, Margaret A Pericak-Vance, Jonathan L Haines
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82194 (2013)
Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene
Externí odkaz:
https://doaj.org/article/13b37a1725b24af491ed6c06e102ea2d
Autor:
Kylee L Spencer, Lana M Olson, Nathalie Schnetz-Boutaud, Paul Gallins, Anita Agarwal, Alessandro Iannaccone, Stephen B Kritchevsky, Melissa Garcia, Michael A Nalls, Anne B Newman, William K Scott, Margaret A Pericak-Vance, Jonathan L Haines
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17784 (2011)
A major goal of personalized medicine is to pre-symptomatically identify individuals at high risk for disease using knowledge of each individual's particular genetic profile and constellation of environmental risk factors. With the identification of
Externí odkaz:
https://doaj.org/article/480866bdb1814eee8293a94f0207529d
Autor:
Jeffrey A Canter, Lana M Olson, Kylee Spencer, Nathalie Schnetz-Boutaud, Brent Anderson, Michael A Hauser, Silke Schmidt, Eric A Postel, Anita Agarwal, Margaret A Pericak-Vance, Paul Sternberg, Jonathan L Haines
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2091 (2008)
The objective of this study was to determine if MTND2*LHON4917G (4917G), a specific non-synonymous polymorphism in the mitochondrial genome previously associated with neurodegenerative phenotypes, is associated with increased risk for age-related mac
Externí odkaz:
https://doaj.org/article/2006c475988f4c4e8018aaaafa4d5623
Autor:
Changho Han, J. Scott Daniels, Alice L. Rodriguez, Colleen M. Niswender, Alison R. Gregro, P. Jeffrey Conn, Michael R. Wood, Craig W. Lindsley, Katrina A. Bollinger, Michael W. Wood, Mark E. Duggan, Sichen Chang, Darren W. Engers, Atin Lamsal, Ryan D. Morrison, Andrew S. Felts, Trevor C. Chopko, Nicholas J. Brandon, Nathalie Schnetz-Boutaud, Vincent B. Luscombe, Hyekyung P. Cho, Mike Poslusney, Carrie K. Jones, Donald F. Stec, Thomas M. Bridges, Michael Bubser, Bruce J. Melancon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2224-2228
This letter describes progress towards an M4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant thieno[2,3-c]pyridine core to an equipotent, non-CNS penetrant thieno[2,3-c]pyrdin-7(6H)-one c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c29ef3365adcf94a1df6de7318989723
https://doi.org/10.1016/j.bmcl.2019.06.032
https://doi.org/10.1016/j.bmcl.2019.06.032
Autor:
Bénédicte Dubois, Lucia Corrado, Deborah F. Mason, Allan G. Kermode, Pentti J. Tienari, Annette Bang Oturai, Charles Hillier, Adrian J. Ivinson, Stephen L. Hauser, Ashley Beecham, Jeannette Lechner-Scott, Vincent Thijs, Jonathan L. Haines, Sarah Edkins, Alexander T. Dilthey, Daniele Cusi, Guy Nagels, David A. Hafler, Mark Slee, Petra Nilsson, James S. Wiley, Lou Brundin, Amy Strange, Elizabeth Visser, Mireia Sospedra, Athena Hadjixenofontos, Sergio E. Baranzini, Jenny Link, Robert Andrews, Viola Biberacher, Helle Bach Søndergaard, Vittorio Martinelli, Tomas Olsson, Gillian L Hall, Stephen Sawcer, Stacy J. Caillier, Per Soelberg Sørensen, Céline Bellenguez, Cornelia M. van Duijn, Frauke Zipp, Nikolaos A. Patsopoulos, Cristin McCabe, Colin Freeman, Simon Broadley, Luisa Bernardinelli, Margaret A. Pericak-Vance, Jan Hillert, Wassila Carpentier, Sandip Shaunak, Anne Spurkland, Barnaby Fiddes, Judith Field, Jan Lycke, Christina M. Lill, Federica Esposito, Ioanna Konidari, Elisabeth Gulowsen Celius, Christian Gieger, Helmut Butzkueven, Ling Shen, James F. Wilson, Magdalena Lindén, Tejas S. Shah, Amie Baker, Dionysia K. Xifara, Hong Quach, Laura Bergamaschi, Rogier Q. Hintzen, Jacob L. McCauley, Janna Saarela, J W Thorpe, Christine Lebrun-Frenay, Felix Luessi, Sandra D'Alfonso, B. E. Kendall, Helga Westerlind, Giancarlo Comi, Nathalie Schnetz-Boutaud, Paola Brambilla, Chris Cotsapas, Anders Hamsten, William Camu, Achim Berthele, Kjell-Morten Myhr, Clive Hawkins, Richard Nicholas, James Harley, Carl A. Anderson, Keijo Koivisto, Irene Coman, Neil Robertson, Hakon Hakonarson, Finn Sellebjerg, Fredrik Piehl, Alessia Di Sapio, Loukas Moutsianas, Mehdi Alizadeh, Lars Alfredsson, Catherine Schaefer, David Rog, Virpi Leppa, C. Martin, Bruce A.C. Cree, Christopher Halfpenny, Irina Elovaara, Filippo Martinelli-Boneschi, Cordelia Langford, Hanne F. Harbo, Wim Robberecht, Isabelle Cournu-Rebeix, Steve Vucic, Izaura Lima Bomfim, Irene Y. Frohlich, Michelle Lee, Bertrand Fontaine, Bernhard Hemmer, Eva Zindler, Chris C. A. Spencer, Malin Larsson, Simon Shields, Ilijas Jelcic, Juliane Winkelmann, Jorge R. Oksenberg, Alastair Wilkins, Silvia Delgado, Volker Siffrin, Helena C. Kronsbein, Bruno Brochet, Panos Deloukas, Daniela Galimberti, Nikos Evangelou, Rebecca C. Selter, Maja Jagodic, Martin Duddy, Timothy Harrower, Per Hall, Nadia Barizzone, Siân Price, Matti Pirinen, Pierre-Antoine Gourraud, Thomas M.C. Binder, Giuseppe Liberatore, Mark Lathrop, M.-M. Hoshi, Garrett Hellenthal, Melissa Sorosina, Thomas Korn, Clara Guaschino, Roland Martin, Jeremy Hobart, Marco Salvetti, Peter Donnelly, Ingrid Kockum, An Goris, Alastair Compston, Mariaemma Rodegher, Dorothea Buck, Clara P. Manrique, Christiane Graetz, Benedicte A. Lie, Trevor J. Kilpatrick, Andrew Graham, Anu Kemppinen, Maria Ban, Gil McVean, John Zajicek, Hannah Blackburn, Mary F. Davis, Emilie Sundqvist, Bruce V. Taylor, Maurizio Leone, Lisa F. Barcellos, Fabio Macciardi, Gilles Defer, Vincent Damotte, Satu Männistö, Graeme J. Stewart, Gordon Mazibrada, Inger Lise Mero, Andre Franke, Philip L. De Jager, Verena Grummel, Mauri Reunanen, David R. Booth, Anna Ticca, Angela Jochim, Leentje Cosemans, Julia Y Mescheriakova, Cristina Agliardi, Paola Cavalla, Jeffrey C. Barrett, Sarah E. Hunt, Gavin Band
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2013, 45 (11), pp.1353-1360. ⟨10.1038/ng.2770⟩
Beecham, A H, Patsopoulos, N A, Xifara, D K, Davis, M F, Kemppinen, A, Cotsapas, C, Shah, T S, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, H F, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, J R, Hintzen, R, Barcellos, L F, Agliardi, C, Alfredsson, L, Alizadeh, M, Anderson, C, Andrews, R, Søndergaard, H B, Baker, A, Band, G, Baranzini, S E, Barizzone, N, Barrett, J, Bellenguez, C, Bergamaschi, L, Bernardinelli, L, Berthele, A, Biberacher, V, Binder, T M C, Blackburn, H, Bomfim, I L, Brambilla, P, Broadley, S, Wilson, J F & Henderson, P 2013, ' Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis ', Nature Genetics, vol. 45, no. 11, pp. 1353-60 . https://doi.org/10.1038/ng.2770
Nature genetics
Nature Genetics, 2013, 45 (11), pp.1353-1360. ⟨10.1038/ng.2770⟩
Nature Genetics, 45(11), 1353-+. Nature Publishing Group
Nature Genetics, Nature Publishing Group, 2013, 45 (11), pp.1353-1360. ⟨10.1038/ng.2770⟩
Beecham, A H, Patsopoulos, N A, Xifara, D K, Davis, M F, Kemppinen, A, Cotsapas, C, Shah, T S, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, H F, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, J R, Hintzen, R, Barcellos, L F, Agliardi, C, Alfredsson, L, Alizadeh, M, Anderson, C, Andrews, R, Søndergaard, H B, Baker, A, Band, G, Baranzini, S E, Barizzone, N, Barrett, J, Bellenguez, C, Bergamaschi, L, Bernardinelli, L, Berthele, A, Biberacher, V, Binder, T M C, Blackburn, H, Bomfim, I L, Brambilla, P, Broadley, S, Wilson, J F & Henderson, P 2013, ' Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis ', Nature Genetics, vol. 45, no. 11, pp. 1353-60 . https://doi.org/10.1038/ng.2770
Nature genetics
Nature Genetics, 2013, 45 (11), pp.1353-1360. ⟨10.1038/ng.2770⟩
Nature Genetics, 45(11), 1353-+. Nature Publishing Group
International audience; Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaed6c6a6596c74a380f29f543038e03
https://doi.org/10.1038/ng.2770
https://doi.org/10.1038/ng.2770
Autor:
Jonathan L. Haines, Nathalie Schnetz-Boutaud, Michael L. Cuccaro, A. M. Wotawa, B. M. Anderson, Jacquelaine Bartlett, Harry H. Wright, J. R. Gilbert, Ruth K. Abramson, Margaret A. Pericak-Vance
Publikováno v:
neurogenetics. 10:209-216
Autism is characterized as one of the pervasive developmental disorders, a spectrum of often severe behavioral and cognitive disturbances of early development. The high heritability of autism has driven multiple efforts to identify genetic variation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfea57d63154832dc832bee0355e28bc
https://doi.org/10.1007/s10048-009-0171-7
https://doi.org/10.1007/s10048-009-0171-7
Autor:
Ruth K. Abramson, Jill Gilbert, Jonathan L. Haines, Jacquelaine Bartlett, Nathalie Schnetz-Boutaud, Michael L. Cuccaro, B. M. Anderson, Harry H. Wright, Margaret A. Pericak-Vance
Publikováno v:
Autism Research. 1:364-369
Autism is a severe neurodevelopmental disorder characterized by a triad of complications. Autistic individuals display significant disturbances in language and reciprocal social interactions, combined with repetitive and stereotypic behaviors. Preval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b49fac3cde9f11b1900d07bc1b1645
https://doi.org/10.1002/aur.55
https://doi.org/10.1002/aur.55
Publikováno v:
Chemical Research in Toxicology. 20:1200-1210
The OPdG adduct N (2)-(3-oxo-1-propenyl)dG, formed in DNA exposed to malondialdehyde, was introduced into 5'-d(ATCGC XCGGCATG)-3'.5'-d(CATGCCGCGAT)-3' at pH 7 (X = OPdG). The OPdG adduct is the base-catalyzed rearrangement product of the M 1dG adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf403e94e3b49b06d08ba695b915dbf9
https://doi.org/10.1021/tx700121j
https://doi.org/10.1021/tx700121j
Autor:
Jonathan L. Haines, Eric A. Postel, John R. Gilbert, Paul Gallins, Silke Schmidt, Nathalie Schnetz-Boutaud, Michael A. Hauser, Kylee L. Spencer, Margaret A. Pericak-Vance, William K. Scott, Anita Agarwal
Publikováno v:
Ophthalmology. 114:1151-1156
Objective To examine the potential gene–environment interaction between cigarette smoking and the complement factor H (CFH) T1277C polymorphism, 2 strong risk factors for age-related macular degeneration (AMD). Design Retrospective case–control s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de3ec23c0a1efb76ffa5e196eed2fd2
https://doi.org/10.1016/j.ophtha.2006.08.054
https://doi.org/10.1016/j.ophtha.2006.08.054