Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nathalie Rouleau"'
Autor:
Stephane Parent, Nathalie Rouleau, Marie-Elaine Caruso, Paule Clément, Vincent Dupriez, Roger Bossé
Publikováno v:
ASSAY and Drug Development Technologies. 11:423-434
The epidermal growth factor receptor (EGFR) pathway is one of the most deregulated molecular pathways in human epithelial cancers. Many approved drugs were optimized to directly target EGFR but yielded only modest clinical improvement in cancer patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1877ee1714aae6c229e2a6e1bb314781
https://doi.org/10.1089/adt.2013.518
https://doi.org/10.1089/adt.2013.518
Autor:
Olivier Pluquet, Philippe Roby, Marion Bouchecareilh, Michel Moenner, Eric Chevet, Saïd Taouji, Stephane Parent, Marie-Elaine Caruso, Roger Bossé, Nathalie Rouleau
Publikováno v:
SLAS Discovery. 15:406-417
Assay technologies that were originally developed for high-throughput screening (HTS) have recently proven useful in drug discovery for activities located upstream (target identification and validation) and downstream (ADMET) of HTS. Here the authors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f03f22b455c8cc316cae00dde66b6e
https://doi.org/10.1177/1087057110363823
https://doi.org/10.1177/1087057110363823
Autor:
Philippe Roby, Richard M. Eglen, Martina Bielefeld, Chantal Illy, Terry Reisine, Roger Bossé, Nathalie Rouleau
Publikováno v:
Current Chemical Genomics
AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay Screen) is versatile assay technology developed to measuring analytes using a homogenous protocol. This technology is an example of a bead-based proximity assay and was developed from a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b757aa6cdabe3be120fe490976301e6
https://doi.org/10.2174/1875397300801010002
https://doi.org/10.2174/1875397300801010002
Autor:
Cheryl Wolting, Warren Sun, Karen Stanger, Daniela Rotin, Aaron Gajadhar, Bart Kus, Rob Cho, Aled M. Edwards, Roger Bosse, Donovan Chan, Tammy K. Lee, Nathalie Rouleau
Publikováno v:
Journal of Biological Chemistry. 280:29470-29478
Ubiquitin-protein ligases (E3s) are implicated in various human disorders and are attractive targets for therapeutic intervention. Although most cellular proteins are ubiquitinated, ubiquitination cannot be linked directly to a specific E3 for a larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5189d894971566612a63729f789d5c2
https://doi.org/10.1074/jbc.m502197200
https://doi.org/10.1074/jbc.m502197200
Publikováno v:
SLAS Discovery. 8:191-197
The interaction between nuclear receptors (NRs) and their coactivators, a key step in transcription regulation, requires a short consensus sequence called the LXXLL motif found in the coactivators' structure. Using the AlphaScreen technology, the aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b546205579cf35a4afc0b3c42052b836
https://doi.org/10.1177/1087057103252605
https://doi.org/10.1177/1087057103252605
Autor:
Nathalie Rouleau, Tom Owen-Hughes, Anu-Maarit Moilanen, Zhigang Kang, Olli A. Jänne, Kristina M. Havas, Jorma J. Palvimo, Mati Reeben, Andrii Domanskyi
Publikováno v:
Molecular Biology of the Cell. 13:2106-2119
Nuclear receptors, including the androgen receptor (AR), regulate target cell transcription through interaction with auxiliary proteins to modify chromatin structure. We describe herein a novel AR-interacting protein, termed ARIP4, that has structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd34505f5d5481c8b8b6d862cf5c979
https://doi.org/10.1091/mbc.01-10-0484
https://doi.org/10.1091/mbc.01-10-0484
Autor:
Yuan Chen, Jianghai Wang, Nathalie Rouleau, Elizabeth Andrews, Martina Bielefeld-Sevigny, Labrini Karras
Publikováno v:
Analytical Biochemistry. 375:364-366
Small ubiquitin-like proteins (SUMO) are recently discovered post-translational modifiers that regulate protein functions and intracellular trafficking. In this study, we are describing two chemoluminescence-based assays, one for SUMOylation and anot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d624f88b0c4dc5a5be02a736ff6646
https://doi.org/10.1016/j.ab.2007.11.024
https://doi.org/10.1016/j.ab.2007.11.024
Autor:
Franklin Spriggs, Zhandong Don Zhong, Chad Ray, Saloumeh K Fischer, Jenny Ly, Martin Boissonneault, Darshana Jani, Narasaiah Dontha, Nathalie Rouleau, Anita Kant, Lia Brilando, Afshin Safavi, Karolina Österlund
Publikováno v:
The AAPS journal. 14(1)
The 21st Century Bioanalytical Laboratory Platforms initiative in the BIOTEC section of the American Association of Pharmaceutical Scientists (AAPS) began with a pre-conference workshop held in Seattle, WA in June of 2009. This workshop brought toget
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a579bacaee1dbcad1826b598f84c4b1
https://pubmed.ncbi.nlm.nih.gov/22454839
https://pubmed.ncbi.nlm.nih.gov/22454839
Autor:
M G Caron, Anja Rodenbrock, Lucille Beaudet, Claire Normand, Jaime Padrós, Nathalie Rouleau, Valérie Paquet, Nancy Gauthier, Anne Labonté, Mathieu Arcand, Roberto J. Rodriguez-suarez, Julie Blouin, Marjolaine Roy, Liliana Pedro
Publikováno v:
Journal of biomolecular screening. 17(1)
Histone posttranslational modifications are among the epigenetic mechanisms that modulate chromatin structure and gene transcription. Histone methylation and demethylation are dynamic processes controlled respectively by histone methyltransferases (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1daa88526b404b50d04edc38977f8f
https://pubmed.ncbi.nlm.nih.gov/21940714
https://pubmed.ncbi.nlm.nih.gov/21940714
Autor:
Roger Bossé, Nathalie Rouleau
Publikováno v:
Handbook of Assay Development in Drug Discovery ISBN: 9781574444711
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a8cae1641c9fed4723d88a7a2a2c6c6
https://doi.org/10.1201/9781420015706.ch15
https://doi.org/10.1201/9781420015706.ch15
