Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Nathalie Reuter"'
Autor:
Anne M. Kiirikki, Hanne S. Antila, Lara S. Bort, Pavel Buslaev, Fernando Favela-Rosales, Tiago Mendes Ferreira, Patrick F. J. Fuchs, Rebeca Garcia-Fandino, Ivan Gushchin, Batuhan Kav, Norbert Kučerka, Patrik Kula, Milla Kurki, Alexander Kuzmin, Anusha Lalitha, Fabio Lolicato, Jesper J. Madsen, Markus S. Miettinen, Cedric Mingham, Luca Monticelli, Ricky Nencini, Alexey M. Nesterenko, Thomas J. Piggot, Ángel Piñeiro, Nathalie Reuter, Suman Samantray, Fabián Suárez-Lestón, Reza Talandashti, O. H. Samuli Ollila
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Tools based on artificial intelligence (AI) are currently revolutionising many fields, yet their applications are often limited by the lack of suitable training data in programmatically accessible format. Here we propose an effective solutio
Externí odkaz:
https://doaj.org/article/acfa193917a24cbab8ffde269f7d7c0d
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0294827 (2024)
Neutrophil proteinase 3 (PR3) is an important drug target for inflammatory lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Drug discovery efforts targeting PR3 require active enzyme for in vitro characterization, such
Externí odkaz:
https://doaj.org/article/fc1527840d6345d0bbe0675811fd2772
Publikováno v:
Membranes, Vol 14, Iss 5, p 105 (2024)
The role of aromatic amino acids in peripheral protein membrane binding has been reported to involve cation–π interactions with choline lipids. In this study, we have investigated the interactions of the model pentapeptide Ac-WL-X-LL-OH (where X =
Externí odkaz:
https://doaj.org/article/2236dd2f8d6344d8929eb0285c61c6f4
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010346 (2022)
Peripheral membrane proteins (PMPs) include a wide variety of proteins that have in common to bind transiently to the chemically complex interfacial region of membranes through their interfacial binding site (IBS). In contrast to protein-protein or p
Externí odkaz:
https://doaj.org/article/baa78e879db243cb9148d40ca13e6c12
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 532-547 (2020)
N-terminal acetyltransferases (NATs) belong to the superfamily of acetyltransferases. They are enzymes catalysing the transfer of an acetyl group from acetyl coenzyme A to the N-terminus of polypeptide chains. N-terminal acetylation is one of the mos
Externí odkaz:
https://doaj.org/article/c0bab6a947cb4e70817490881c617cf5
Autor:
Emmanuel E Moutoussamy, Qaiser Waheed, Greta J Binford, Hanif M Khan, Shane M Moran, Anna R Eitel, Matthew H J Cordes, Nathalie Reuter
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009871 (2022)
Spider venom GDPD-like phospholipases D (SicTox) have been identified to be one of the major toxins in recluse spider venom. They are divided into two major clades: the α clade and the β clade. Most α clade toxins present high activity against lip
Externí odkaz:
https://doaj.org/article/a50e9a4e541b4ce4a972ecd447bb3e19
Publikováno v:
Molecules, Vol 27, Iss 19, p 6184 (2022)
Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes are a virulence factor in many Gram-positive organisms. The specific activity of the Bacillus thuringiensis PI-PLC is significantly increased by adding phosphatidylcholine (PC) to vesicle
Externí odkaz:
https://doaj.org/article/23f3e0f487c74cf48d77ddb631a9ccc9
Publikováno v:
Advances in Physics: X, Vol 6, Iss 1 (2021)
Peripheral membrane proteins (PMPs) bind temporarily to the surface of biological membranes. They also exist in a soluble form and their tertiary structure is often known. Yet, their membrane-bound form and their interfacial-binding site with membran
Externí odkaz:
https://doaj.org/article/edf82aaaaf7f4af0a644dae6e2cd38a9
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1007988 (2020)
The enzymes of the GCN5-related N-acetyltransferase (GNAT) superfamily count more than 870 000 members through all kingdoms of life and share the same structural fold. GNAT enzymes transfer an acyl moiety from acyl coenzyme A to a wide range of subst
Externí odkaz:
https://doaj.org/article/ba2c21e0af314c908e0fcdd3570aee64
Autor:
Edvin Fuglebakk, Nathalie Reuter
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 7, p e1006325 (2018)
With remarkable spatial and temporal specificities, peripheral membrane proteins bind to biological membranes. They do this without compromising solubility of the protein, and their binding sites are not easily distinguished. Prototypical peripheral
Externí odkaz:
https://doaj.org/article/86f4c21cf4414dccadddeb3d65dc1eb0