Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing miceResearch in context

Autor: Silvia Marino, Daniëlle de Ridder, Ryan T. Bishop, Nathalie Renema, Marco Ponzetti, Antonia Sophocleous, Mattia Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, Asim Khogeer, Stuart H. Ralston, Jürg Gertsch, Francois Lamoureux, Dominique Heymann, Nadia Rucci, Aymen I. Idris

Publikováno v: EBioMedicine, Vol 44, Iss , Pp 452-466 (2019)

Background: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degra

Externí odkaz: https://doaj.org/article/ebe9f63efbf641769fb4ae082d43376f

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A

Autor: Daniëlle de Ridder, Silvia Marino, Ryan T. Bishop, Nathalie Renema, Chantal Chenu, Dominique Heymann, Aymen I. Idris

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Abstract Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing. Here, we report a previously unknown role of Sema3A in the regulation of ectop

Externí odkaz: https://doaj.org/article/994150735f414fcf99e03f4cca7c2b49

Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice

Autor: Daniëlle de Ridder, Mattia Capulli, Aymen I. Idris, Stuart H. Ralston, Francois Lamoureux, Ryan T. Bishop, Nathalie Renema, J Gertsch, Silvia Marino, Giovana Carrasco, Antonia Sophocleous, Abdullah Aljeffery, Dominique Heymann, Marco Ponzetti, Nadia Rucci, Asim Khogeer, Marianela Dalghi Gens

Publikováno v: Marino, Silvia; de Ridder, Daniëlle; Bishop, Ryan T; Renema, Nathalie; Ponzetti, Marco; Sophocleous, Antonia; Capulli, Mattia; Aljeffery, Abdullah; Carrasco, Giovana; Dalghi Gens, Marianela; Khogeer, Asim; Ralston, Stuart H; Gertsch, Jürg; Lamoureux, Francois; Heymann, Dominique; Rucci, Nadia; Idris, Aymen I (2019). Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice. EBioMedicine, 44, pp. 452-466. Elsevier 10.1016/j.ebiom.2019.05.048
Marino, S, de Ridder, D, Bishop, R T, Renema, N, Ponzetti, M, Sophocleous, A, Capulli, M, Aljeffery, A, Carrasco, G, Gens, M D, Khogeer, A, Ralston, S H, Gertsch, J, Lamoureux, F, Heymann, D, Rucci, N & Idris, A I 2019, ' Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice ', EBioMedicine, vol. 44, pp. 452-466 . https://doi.org/10.1016/j.ebiom.2019.05.048

Background: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b882aca44604b85a9659724a7212be

Murine Models of Bone Sarcomas

Autor: Agamemnon E. Grigoriadis, Nathalie Renema, Camille Jacques, Dominique Heymann, Benjamin Ory, Carl R. Walkley

Publikováno v: Methods in Molecular Biology ISBN: 9781493989966
Bone Research Protocols
Bone Research Protocols, pp.331-342, 2019

This chapter describes the procedures for inducing bone sarcoma in mice. Two models based on inoculation of cancer cells in paraosseous and intraosseous site will be described. In addition to providing technical aspects of anesthesia and surgical opt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7f92823adbe6920becd19b152d40b5
https://doi.org/10.1007/978-1-4939-8997-3_18

Paradoxical Effects of JZL184, an Inhibitor of Monoacylglycerol Lipase, on Bone Remodelling in Healthy and Cancer-Bearing Mice

Autor: Aymen I. Idris, Stuart H. Ralston, Ryan T. Bishop, Dominique Heymann, Daniëlle de Ridder, Jürg Gertsch, Francois Lamoureux, Mattia Capulli, Nadia Rucci, Marianela Dalghi Gens, Asim Kheeger, Nathalie Renema, Abdullah Aljeffery, Marco Ponzetti, Antonia Sophocleous, Silvia Marino, Giovana Carrasco

Publikováno v: SSRN Electronic Journal.

Cancer associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degradation of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::116d361983ad96cea37a0aae0de308d9
https://doi.org/10.2139/ssrn.3301619