Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nathalie R Reinhard"'
Autor:
Marieke Mastop, Nathalie R Reinhard, Cristiane R Zuconelli, Fenna Terwey, Theodorus W J Gadella, Jakobus van Unen, Merel J W Adjobo-Hermans, Joachim Goedhart
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195649 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0193705.].
Externí odkaz:
https://doaj.org/article/0b005f688a0b4cbe86761776992737de
Autor:
Marieke Mastop, Nathalie R Reinhard, Cristiane R Zuconelli, Fenna Terwey, Theodorus W J Gadella, Jakobus van Unen, Merel J W Adjobo-Hermans, Joachim Goedhart
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193705 (2018)
Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs). To this end, FRET based biosensors are made, employing heterotrimeric G-protein subunits
Externí odkaz:
https://doaj.org/article/fb7f53712c4d43f2ba1afea9d76b4818
Autor:
Jakobus van Unen, Anette D Stumpf, Benedikt Schmid, Nathalie R Reinhard, Peter L Hordijk, Carsten Hoffmann, Theodorus W J Gadella, Joachim Goedhart
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146789 (2016)
G-protein coupled receptors (GPCRs) can activate a heterotrimeric G-protein complex with subsecond kinetics. Genetically encoded biosensors based on Förster resonance energy transfer (FRET) are ideally suited for the study of such fast signaling eve
Externí odkaz:
https://doaj.org/article/112c57089ccf4aa78c57144f016e1bfe
Autor:
Nathalie R. Reinhard, Ana Jimenez Orgaz, Ugne Kazlauskaite, Simon Tol, Ivo van der Bijl, Anne-Marieke D. van Stalborch, Iman van den Bout, Arnoud Sonnenberg, Kalim Nawaz, Coert Margadant
Publikováno v:
Matrix biology, 93, 60-78. Elsevier
Collective cell behaviour during embryogenesis and tissue repair requires the coordination of intercellular junctions, cytoskeleton-dependent shape changes controlled by Rho GTPases, and integrin-dependent cell-matrix adhesion. Many different integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878c37e4eaa11c8dd21de79cde1fcaf0
https://doi.org/10.1016/j.matbio.2020.05.005
https://doi.org/10.1016/j.matbio.2020.05.005
Autor:
Joana Amado-Azevedo, Nathalie R. Reinhard, G.P. van Nieuw Amerongen, Peter L. Hordijk, Victor W.M. van Hinsbergh, J. van Bezu
Publikováno v:
Amado-Azevedo, J, Reinhard, N R, van Bezu, J, van Nieuw Amerongen, G P, van Hinsbergh, V W M & Hordijk, P L 2018, ' The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity ', Vascular Pharmacology, vol. 101, pp. 38-47 . https://doi.org/10.1016/j.vph.2017.11.007
Vascular Pharmacology, 101, 38-47. Elsevier Inc.
Vascular Pharmacology, 101, 38-47. Elsevier Inc.
Endothelial cells line the vasculature and act as gatekeepers that control the passage of plasma, macromolecules and cells from the circulation to the interstitial space. Dysfunction of the endothelial barrier can lead to uncontrolled leak or edema.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76822081db90db8fd4a39be93dd962ce
https://doi.org/10.1016/j.vph.2017.11.007
https://doi.org/10.1016/j.vph.2017.11.007
Autor:
Peter L. Hordijk, Theodorus W. J. Gadella, Esmeralda K. Bosma, Nathalie R. Reinhard, Joachim Goedhart, Yi I. Wu, Marieke Mastop, Taofei Yin
Publikováno v:
Molecular biology of the cell, 28(23), 3371-3382. American Society for Cell Biology
Molecular Biology of the Cell, 28(23), 3371-3382. American Society for Cell Biology
Reinhard, N R, Mastop, M, Yin, T, Wu, Y, Bosma, E K, Gadella, T W J, Goedhart, J & Hordijk, P L 2017, ' The balance between Gα i-Cdc42/Rac and Gα 1/ 2/ 13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate ', Molecular Biology of the Cell, vol. 28, no. 23, pp. 3371-3382 . https://doi.org/10.1091/mbc.E17-03-0136
Molecular Biology of the Cell, 28(23), 3371-3382. American Society for Cell Biology
Reinhard, N R, Mastop, M, Yin, T, Wu, Y, Bosma, E K, Gadella, T W J, Goedhart, J & Hordijk, P L 2017, ' The balance between Gα i-Cdc42/Rac and Gα 1/ 2/ 13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate ', Molecular Biology of the Cell, vol. 28, no. 23, pp. 3371-3382 . https://doi.org/10.1091/mbc.E17-03-0136
The bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins, and involved in many physiological processes, including angiogenesis, inflammatory responses, and vascular stabilization. S1P can bind to several G-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe2ae73b96e3b0c6d308cba4eec2b7b
https://doi.org/10.1091/mbc.e17-03-0136
https://doi.org/10.1091/mbc.e17-03-0136
Autor:
Peter L. Hordijk, Theodorus W. J. Gadella, Anna O. Chertkova, Sanne van der Niet, Joachim Goedhart, Nathalie R. Reinhard, Marten Postma
The Rho GTPase family is involved in actin dynamics and regulates the barrier function of the endothelium. One of the main barrier-promoting Rho GTPases is Cdc42, also known as cell division control protein 42 homolog. Currently, regulation of Cdc42-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f225042023f779b3ce1fc20dd2666
Autor:
Victor W.M. van Hinsbergh, G.P. van Nieuw Amerongen, Victor W. van Beusechem, Nathalie R. Reinhard, Joana Amado-Azevedo, Peter L. Hordijk, Rene X. Menezes, J. van Bezu
Publikováno v:
Scientific Reports, 7(1):10132. Nature Publishing Group
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Amado-Azevedo, J, Reinhard, N R, van Bezu, J, Menezes, R X, Van Beusechem, V W, Van Nieuw Amerongen, G P, Van Hinsbergh, V W M & Hordijk, P L 2017, ' A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity ', Scientific Reports, vol. 7, no. 1, 10132 . https://doi.org/10.1038/s41598-017-10392-0
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Amado-Azevedo, J, Reinhard, N R, van Bezu, J, Menezes, R X, Van Beusechem, V W, Van Nieuw Amerongen, G P, Van Hinsbergh, V W M & Hordijk, P L 2017, ' A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity ', Scientific Reports, vol. 7, no. 1, 10132 . https://doi.org/10.1038/s41598-017-10392-0
Endothelial barrier function is carefully controlled to protect tissues from edema and damage inflicted by extravasated leukocytes. RhoGTPases, in conjunction with myriad regulatory proteins, exert both positive and negative effects on the endothelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e2edfb8a00071b8f28323266b57502
https://doi.org/10.1038/s41598-017-10392-0
https://doi.org/10.1038/s41598-017-10392-0
Autor:
Nathalie R. Reinhard, Cristiane R. Zuconelli, Jakobus van Unen, Fenna Terwey, Joachim Goedhart, Marieke Mastop, Merel J. W. Adjobo-Hermans, Theodorus W. J. Gadella
Publikováno v:
PLoS ONE
PLoS One, 13, 3
PLoS ONE, 13(3):e0193705. Public Library of Science
PLoS ONE, Vol 13, Iss 3, p e0193705 (2018)
PLoS One, 13
PLoS One, 13, 3
PLoS ONE, 13(3):e0193705. Public Library of Science
PLoS ONE, Vol 13, Iss 3, p e0193705 (2018)
PLoS One, 13
Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs). To this end, FRET based biosensors are made, employing heterotrimeric G-protein subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989e1c0da9c58cc0c4727123a6fc228d
https://pubmed.ncbi.nlm.nih.gov/29617442
https://pubmed.ncbi.nlm.nih.gov/29617442
Autor:
Fenna Terwey, Nathalie R. Reinhard, Joachim Goedhart, Marieke Mastop, Theodorus W. J. Gadella, Cristiane R. Zuconelli, Jakobus van Unen, Merel J. W. Adjobo-Hermans
Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs). To this end, FRET based biosensors are made, employing heterotrimeric G-protein subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877a5460d91ce737766958f221374567
https://doi.org/10.1101/220632
https://doi.org/10.1101/220632