Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nathalie Pacico"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84755 (2014)
Research in the epilepsy field is moving from a primary focus on controlling seizures to addressing disease pathophysiology. This requires the adoption of resource- and time-consuming animal models of chronic epilepsy which are no longer able to sust
Externí odkaz:
https://doaj.org/article/ce0fbc5a4f2245f09d23a748309d9c28
Autor:
Berni Sweeney, Marta Westwood, Kerry Louise Tyson, David McMillan, Geofrey Odede, Gillian Burgess, Terry Baker, Daniel John Lightwood, Patrick Downey, Georges Mairet-Coello, Rebecca Munro, Martin Citron, Robert G. Griffin, Dale Starkie, Marie-Laetitia Mushikiwabo, Nathalie Pacico, Ruodan Nan, Sophie Jung, Rachel Angers, Jean-Philippe Courade, Andrew George Popplewell
Publikováno v:
Acta Neuropathologica
In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive sprea
Publikováno v:
Pharmacology. 96:131-136
Background/Aims: To this date, the only available drugs for treating Alzheimer's disease are cognitive enhancers, which may improve the cognitive function of patients for a few years while the disease continues to progress. As such, there are intense
Autor:
Stéphane Meunier, Laurent Provins, Philippe Collart, Ananda Kumar Kanduluru, Christian Wolff, Marie-Laure Delporte, Alain Wagner, Nathalie Pacico, Sébastien Lengelé, Cecile Pegurier, Lakshmana Rao Vadali, Nathalie Bosman, Karine Leclercq
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2542-2545
The discovery and optimization of a novel class of selective submicromolar KCC2 blockers is described. Details of synthesis and SAR are given together with ADME properties of selected compounds. A methylsulfone residue on the R(1) phenyl group improv
Autor:
Michael G. Narotsky, Jacques J. Picard, Nathalie Pacico, Françoise Gofflot, Nathalie Wéry, Robert J. Kavlock
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 67:59-67
BACKGROUND: Previously, we showed that prenatal exposure to boric acid (BA), an industrial agent with large production, causes alterations of the axial skeleton in rat embryos, reminiscent of homeotic transformations. Indeed, Sprague-Dawley rats expo
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84755 (2014)
PLoS ONE
PLoS ONE
Research in the epilepsy field is moving from a primary focus on controlling seizures to addressing disease pathophysiology. This requires the adoption of resource- and time-consuming animal models of chronic epilepsy which are no longer able to sust
Autor:
Nathalie Pacico, Philippe Ghisdal, Nadine Noel, Etienne Hanon, Patrik Foerch, Murielle Martini, Christian Wolff
Publikováno v:
Journal of biomolecular screening. 19(3)
Gamma amino butyric acid receptors (GABA) are major therapeutic targets for the development of drugs in neurological and psychiatric disorders. The new generation of GABAA modulators is targeting subtype selectivity and low/partial efficacy on the re
Autor:
Jacques J. Picard, Leïla Abbas, Sophie Remacle, René Rezsohazy, Nathalie Pacico, Anthony Gavalas, Françoise Gofflot, Olivier De Backer
Publikováno v:
Molecular and Cellular Biology, Vol. 24, no. 19, p. 8567-75 (2004)
Homeodomain containing transcription factors of the Hox family play critical roles in patterning the anteroposterior embryonic body axis, as well as in controlling several steps of organogenesis. Several Hox proteins have been shown to cooperate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7ce8aad0ad662488ad3ced9bb9d6e5
https://europepmc.org/articles/PMC516739/
https://europepmc.org/articles/PMC516739/
Autor:
Nathalie, Wéry, Michael G, Narotsky, Nathalie, Pacico, Robert J, Kavlock, Jacques J, Picard, Françoise, Gofflot
Publikováno v:
Birth defects research. Part A, Clinical and molecular teratology. 67(1)
Previously, we showed that prenatal exposure to boric acid (BA), an industrial agent with large production, causes alterations of the axial skeleton in rat embryos, reminiscent of homeotic transformations. Indeed, Sprague-Dawley rats exposed in utero