Výsledky vyhledávání - "Nathalie O. P. van Uden"

Generation and Characterization of Anti–Citrullinated Protein Antibody–Producing B Cell Clones From Rheumatoid Arthritis Patients

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.), 71(3), 340-350. John Wiley and Sons Ltd
Arthritis and Rheumatology, 71(3), 340-350

Objective Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA). Aside from autoantibody production, the function of autoantigen-specific B cells remains poorly understood in the context of this disease. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae26a4e9fc8395d769facd9f4118af6
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060924655&origin=inward

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BOB.1 controls memory B-cell fate in the germinal center reaction

Autor: Dominique Baeten, Lisa G. M. van Baarsen, Sophie Brouard, Maartje J. Levels, Tom O'Toole, Nataliya Yeremenko, Arjen Q. Bakker, Mikhail Krasavin, Cynthia M. Fehres, JF Semmelink, Iris C Blijdorp, Alexey Tomilin, Marieke E. Doorenspleet, Kristine Germar, Nathalie O. P. van Uden, Hergen Spits

Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, Elsevier, 2019, Epub ahead of print. ⟨10.1016/j.jaut.2019.04.011⟩
Journal of autoimmunity, 101, 131-144. Academic Press Inc.
Journal of Autoimmunity, 2019, Epub ahead of print. ⟨10.1016/j.jaut.2019.04.011⟩
Journal of Autoimmunity, 101, 131-144. Academic Press Inc.
Levels, M J, Fehres, C M, van Baarsen, L G M, van Uden, N O P, Germar, K, O'Toole, T G, Blijdorp, I C J, Semmelink, J F, Doorenspleet, M E, Bakker, A Q, Krasavin, M, Tomilin, A, Brouard, S, Spits, H, Baeten, D L P & Yeremenko, N G 2019, ' BOB.1 controls memory B-cell fate in the germinal center reaction ', Journal of Autoimmunity, vol. 101, pp. 131-144 . https://doi.org/10.1016/j.jaut.2019.04.011

International audience; During T cell-dependent (TD) germinal center (GC) responses, naïve B cells are instructed to differentiate towards GC B cells (GCBC), high-affinity long-lived plasma cells (LLPC) or memory B cells (Bmem). Alterations in the B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e232d10099951e3019af3160a7360f
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067009896&origin=inward

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Immunophenotypic Analysis Reveals Differences in Circulating Immune Cells in the Peripheral Blood of Patients with Segmental and Nonsegmental Vitiligo

Autor: Saskia Chielie, Nicoline F. Post, Marcella Willemsen, Marcel W. Bekkenk, E. Helen Kemp, Rosalie M. Luiten, Nathalie O. P. van Uden, V. S. Narayan

Publikováno v: Journal of Investigative Dermatology. Nature Publishing Group
Journal of investigative dermatology. Nature Publishing Group
Willemsen, M, Post, N F, van Uden, N O P, Narayan, V S, Chielie, S, Kemp, E H, Bekkenk, M W & Luiten, R M 2021, ' Immunophenotypic Analysis Reveals Differences in Circulating Immune Cells in the Peripheral Blood of Patients with Segmental and Nonsegmental Vitiligo ', Journal of Investigative Dermatology . https://doi.org/10.1016/j.jid.2021.05.022

Accumulating studies have indicated immune-based destruction of melanocytes in both segmental vitiligo (SV) and non-SV (NSV). Whereas SV often occurs unilaterally during childhood and stabilizes after an initial period of activity, the disease course

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https://research.vumc.nl/en/publications/7c2d0081-d129-45d7-8b2e-ffea8cae1e1b

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Akademický článek

Respiratory syncytial virus induced type I IFN production by pDC is regulated by RSV-infected airway epithelial cells, RSV-exposed monocytes and virus specific antibodies.

Autor: Marcel A Schijf, Michael V Lukens, Debby Kruijsen, Nathalie O P van Uden, Johan Garssen, Frank E J Coenjaerts, Belinda Van't Land, Grada M van Bleek

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81695 (2013)

Innate immune responses elicited upon virus exposure are crucial for the effective eradication of viruses, the onset of adaptive immune responses and for establishing proper immune memory. Respiratory syncytial virus (RSV) is responsible for a high d

Externí odkaz: https://doaj.org/article/9f818a34cf37438da5a11a6e2f3cc094

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A secondary role for hypoxia and HIF1 in the regulation of (IFNγ-induced) PD-L1 expression in melanoma

Autor: Jan Koster, Karin J. Willemsen, Rosalie M. Luiten, Anneloes van Duijn, Nathalie O. P. van Uden, Lieke L. Hoyng, Sterre Erades, Walbert J. Bakker

Publikováno v: Cancer immunology, immunotherapy. Springer Science and Business Media Deutschland GmbH

Cancer cells are able to escape immune surveillance by upregulating programmed death ligand 1 (PD-L1). A key regulator of PD-L1 expression is transcriptional stimulation by the IFNγ/JAK/STAT pathway. Recent studies suggest that hypoxia can induce PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb1619d04933a9b89498ff2b6f10c63
https://pubmed.ncbi.nlm.nih.gov/34268602

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Serum antibodies critically affect virus-specific CD4+/CD8+ T cell balance during respiratory syncytial virus infections

Autor: Tetje C. van der Sluis, Mark J.G. Bakkers, Debby Kruijsen, Nathalie O. P. van Uden, Grada M. van Bleek, Jan L. L. Kimpen, Marco C. Viveen, Jeanette H. W. Leusen, Frank E. J. Coenjaerts

Publikováno v: Journal of immunology (Baltimore, Md., 185(11), 6489-6498. American Association of Immunologists

Following infection with respiratory syncytial virus (RSV), reinfection in healthy individuals is common and presumably due to ineffective memory T cell responses. In peripheral blood of healthy adults, a higher CD4+/CD8+ memory T cell ratio was obse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef859217cab5ba117aee9ae723c854b0
https://doi.org/10.4049/jimmunol.1002645

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Expression of the pho regulon interferes with induction of the uhpT gene in Escherichia coli K-12

Autor: Jan Tommassen, Nathalie O. P. van Uden, Sally M. Hoffer

Publikováno v: Archives of microbiology, 176(5), 370-376. Springer Verlag

The uptake of hexose 6-phosphates in Escherichia coli is mediated by the transporter UhpT, the synthesis of which is induced by the presence of glucose 6-phosphate (glucose 6-P) in the medium. Since this protein functions as an anion exchanger, it is

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https://doi.org/10.1007/s002030100339

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Local innate and adaptive immune responses regulate inflammatory cell influx into the lungs after vaccination with formalin inactivated RSV

Autor: Jan L. L. Kimpen, Michaël V. Lukens, Grada M. van Bleek, Marcel A. Schijf, Frank E. J. Coenjaerts, Debby Kruijsen, Nathalie O. P. van Uden

Publikováno v: Vaccine, 29(15), 2730-2741. ELSEVIER SCI LTD
Vaccine, 29(15), 2730-2741. Elsevier BV

Inactivated respiratory syncytial virus (RSV) vaccines tend to predispose for immune mediated enhanced disease, characterized by Th2 responses and airway hypersensitivity reactions. We show in a C57BL/6 mouse model that the early innate response elic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110a0a54864259bed3f2e207401d8fcf
https://research.rug.nl/en/publications/f1933002-bd39-4527-967a-4a419e48b20b

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Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles

Autor: Jessica Holthuizen, Lisya Gerez, Nathalie O. P. van Uden, Lucas Pelkmans, Karin Mohrmann, Marcel van Raak, Peter van der Sluijs, Bas Nagelkerken, Eelco van Anken

Publikováno v: Biochemical journal, 346 Pt 3, 593-601. Portland Press Ltd.

The small GTPase rab4a is associated with early endocytic compartments and regulates receptor recycling from early endosomes. To understand how rab4a mediates its function, we searched for proteins which associate with this GTPase and regulate its ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f43c2d21a10ef9103cc7bcba59f4f37
https://pubmed.ncbi.nlm.nih.gov/10698684

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