Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism

Autor: Giuseppina Arbore, Erin E. West, Jubayer Rahman, Gaelle Le Friec, Nathalie Niyonzima, Mehdi Pirooznia, Ilker Tunc, Polychronis Pavlidis, Nicholas Powell, Yuesheng Li, Poching Liu, Aude Servais, Lionel Couzi, Veronique Fremeaux-Bacchi, Leo Placais, Alastair Ferraro, Patrick R. Walsh, David Kavanagh, Behdad Afzali, Paul Lavender, Helen J. Lachmann, Claudia Kemper

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential fo

Externí odkaz: https://doaj.org/article/12d27a6322604934916857f1fe60bd7c

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

Autor: Nathalie Niyonzima, Jubayer Rahman, Natalia Kunz, Erin E. West, Tilo Freiwald, Jigar V. Desai, Nicolas S. Merle, Alexandre Gidon, Bjørnar Sporsheim, Michail S. Lionakis, Kristin Evensen, Beate Lindberg, Karolina Skagen, Mona Skjelland, Parul Singh, Markus Haug, Marieta M. Ruseva, Martin Kolev, Jack Bibby, Olivia Marshall, Brett O’Brien, Nigel Deeks, Behdad Afzali, Richard J. Clark, Trent M. Woodruff, Milton Pryor, Zhi-Hong Yang, Alan T. Remaley, Tom E. Mollnes, Stephen M. Hewitt, Bingyu Yan, Majid Kazemian, Máté G. Kiss, Christoph J. Binder, Bente Halvorsen, Terje Espevik, Claudia Kemper

Publikováno v: Sci Immunol

While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the ‘complosome’, functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. Whether intracellular com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbdb6a3aa181bbb6e2cf643be663fb8
https://doi.org/10.1126/sciimmunol.abf2489

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism

Autor: Poching Liu, Patrick R. Walsh, Yuesheng Li, Claudia Kemper, Jubayer Rahman, Helen J. Lachmann, Leo Placais, Behdad Afzali, Paul Lavender, Alastair Ferraro, Nathalie Niyonzima, Giuseppina Arbore, Mehdi Pirooznia, Gaelle Le Friec, Polychronis Pavlidis, David J. Kavanagh, Nick Powell, Erin E. West, Ilker Tunc, Aude Servais, Lionel Couzi, Véronique Frémeaux-Bacchi

Publikováno v: Arbore, G, West, E E, Rahman, J, Le Friec, G, Niyonzima, N, Pirooznia, M, Tunc, I, Pavlidis, P, Powell, N, Li, Y, Liu, P, Servais, A, Couzi, L, Fremeaux-Bacchi, V, Placais, L, Ferraro, A, Walsh, P R, Kavanagh, D, Afzali, B, Lavender, P, Lachmann, H J & Kemper, C 2018, ' Complement receptor CD46 co-stimulates optimal human CD8 + T cell effector function via fatty acid metabolism ', Nature Communications, vol. 9, no. 1, 4186 . https://doi.org/10.1038/s41467-018-06706-z
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications

The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ T cell (CTL) responses also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99827b7738f7632cdc8034134ccd114a
https://kclpure.kcl.ac.uk/en/publications/0522e94d-7a3a-43aa-8abb-106048652b04

T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity

Autor: Erin E West, Simon Freeley, Martin Kolev, Nathalie Niyonzima, Trine Hyrup Mogensen, Trent M Woodruff, Peter Monk, Knut Lappegard, Terje Espevik, Tom Eirik Mollnes, Mette Christiansen, Claudia Kemper

Publikováno v: The Journal of Immunology. 204:150.23-150.23

Intracellular/autocrine complement proteins have emerged as critical regulators of human Th1 induction and contraction. T cells contain both intracellular C3 and C5 activation systems, with intracellular C3aR1 and C5aR1 stimulation driving T cell hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::414e42c811a639b7266a9dc90ab46500
https://doi.org/10.4049/jimmunol.204.supp.150.23

Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation

Autor: Pål Aukrust, Mona Skjelland, Jan Kristian Damås, Marie Hjelmseth Aune, Katrine Pilely, Bente Halvorsen, Liv Ryan, Nathalie Niyonzima, Terje Espevik, Siril Skaret Bakke, Tom Eirik Mollnes, Peter Garred, Eicke Latz

Publikováno v: Journal of Immunology

Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a compound that solubilizes li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc7c6f06f4ecb3709356cee7192300f
https://pubmed.ncbi.nlm.nih.gov/28855312