Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nathalie Mestdagh"'
Autor:
Maria Elisa Serrano, Guillaume Becker, Mohamed Ali Bahri, Alain Seret, Nathalie Mestdagh, Joël Mercier, Frédéric Mievis, Fabrice Giacomelli, Christian Lemaire, Eric Salmon, André Luxen, Alain Plenevaux
Publikováno v:
Molecules, Vol 24, Iss 9, p 1705 (2019)
The synaptic vesicle protein 2 (SV2) is involved in synaptic vesicle trafficking. The SV2A isoform is the most studied and its implication in epilepsy therapy led to the development of the first SV2A PET radiotracer [18F]UCB-H. The objective of this
Externí odkaz:
https://doaj.org/article/84ac241c4d9c406ca812308191683699
Autor:
Anne Valade, Alain Seret, Joël Mercier, Joël Aerts, Alain Plenevaux, Tim Buchanan, Didier Ledoux, Christine Bastin, Nathalie Mestdagh, Mohamed Ali Bahri, Eric Salmon, Guillaume Becker, André Luxen
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Brain distribution of synaptic vesicle protein 2A was measured with fluorine-18 UCB-H ([18F]UCB-H) and positron emission tomography (PET). Methods Images of synaptic density were acquired in healthy volunteers (two young participants and
Autor:
Alain Seret, Tim Buchanan, Christian Otoul, Frédéric Mievis, Florian Bretin, Fabrice Giacomelli, Nathalie Mestdagh, F Koestler, Geoffrey Warnock, André Luxen, Joël Aerts, Eric Salmon, Alain Plenevaux, Claire Bernard, Roland Hustinx, Mohamed Ali Bahri, Christian Degueldre
Publikováno v:
Molecular Imaging and Biology. 17:557-564
[(18)F]UCB-H is a novel radiotracer with a high affinity for synaptic vesicle glycoprotein 2A (SV2A), a protein expressed in synaptic vesicles. SV2A is the binding site of levetiracetam, a "first-in-class" antiepileptic drug with a distinct but still
Autor:
Joël Aerts, Frédéric Mievis, Anne Valade, Florian Bretin, Joël Mercier, Geoffrey Warnock, Alain Plenevaux, Tim Buchanan, Nathalie Mestdagh, André Luxen, Mohamed Ali Bahri, Martyn Wood, Fabrice Giacomelli, Eric Salmon, Michel Gillard, Christian Lemaire, Alain Seret
Publikováno v:
Journal of Nuclear Medicine. 55:1336-1341
Synaptic vesicle protein 2 isoforms are critical for proper nervous system function and are involved in vesicle trafficking. The synaptic vesicle protein 2A (SV2A) isoform has been identified as the binding site of the antiepileptic levetiracetam (LE
Autor:
Gunnar Antoni, Benoit Kenda, Laurent Provins, Dominique Tytgat, Tim Buchanan, Sergio Estrada, Nathalie Mestdagh, Mark Lubberink, Michel Gillard, Alf Thibblin, Margareta Sprycha, Joël Mercier
Publikováno v:
Nuclear medicine and biology. 43(6)
Introduction Development of a selective and specific high affinity PET tracer, [ 11 C]UCB-A, for the in vivo study of SV2A expression in humans. Radiochemistry and preclinical studies in rats and pigs including development of a tracer kinetic model t
Autor:
Jean‐Pierre Henichart, Nathalie Mestdagh, Raymond Houssin, Corinne Audouin, Marie-Agnes Lassoie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:845-848
N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.
Autor:
Nathalie Mestdagh, Ernst Wülfert
Publikováno v:
Neuroscience Letters. 265:95-98
The effects of bicuculline methiodide (bicuculline) and gabazine, two GABA(A) antagonists, on cytosolic calcium increases (Ca2+ transients) in rat cerebellar granule cells were examined using Fluo-3-spectrofluorometry. Bicuculline (25 microM) markedl
Autor:
Tim Buchanan, Alain Plenevaux, Christine Mella, Mohamed Ali Bahri, Florian Bretin, Joël Aerts, Nathalie Mestdagh, Frédéric Mievis, Eric Salmon, André Luxen, Anne Valade, Geoffrey Warnock, Fabrice Giacomelli
Publikováno v:
Alzheimer's & Dementia. 9
Autor:
Joël Aerts, Alain Plenevaux, Frédéric Mievis, Nathalie Mestdagh, André Luxen, Anne Valade, Tim Buchanan, Mohamed Ali Bahri, Florian Bretin, Geoffrey Warnock, Christian Lemaire, Eric Salmon, Fabrice Giacomelli, Alain Seret
Publikováno v:
EJNMMI Research
Background [18F]UCB-H was developed as a novel radiotracer with a high affinity for synaptic vesicle protein 2A, the binding site for the antiepileptic levetiracetam. The objectives of this study were to evaluate the radiation dosimetry of [18F]UCB-H
Publikováno v:
Biochemical Pharmacology. 48:709-716
Multidrug resistance (MDR) corresponds to the cross-over resistance of tumour cells to structurally unrelated cytotoxic chemotherapeutic drugs. One of the mechanisms causing this resistance is the enhanced expression of a transmembrane drug efflux pu