Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nathalie Jänner"'
Autor:
Athena Chalaris, Nathalie Jänner, Stefan Rose-John, Christoph Garbers, Doreen M. Floss, Dörte Meyer, Marcia L. Moss, Friedrich Koch-Nolte, Jürgen Scheller
Publikováno v:
Journal of Biological Chemistry. 286:14804-14811
Hypomorphic ADAM17(ex/ex) mice showed defects in mucosal regeneration due to inefficient enhanced GFR shedding. ADAM17 is the main sheddase of interleukin-6 receptor (IL-6R) to induce IL-6 trans-signaling. However, serum levels of soluble murine IL-6
Autor:
Jessica Gewiese-Rabsch, Jürgen Scheller, Kosuke Yamamoto, Stefan Rose-John, Nathalie Jänner, Wolfgang Thaiss, Christoph Garbers, Sven Malchow, Georg H. Waetzig
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812:290-301
Neutrophil depleted mice are protected from concanavalin A-mediated hepatitis, showing that neutrophils are critical for cellular liver damage. Interleukin-6 has pro- and anti-inflammatory properties and mediates neutrophil recruitment in diseases su
Autor:
Kirsten Heiss, Birgit Mähnß, Friedrich Koch-Nolte, Friedrich Haag, Valéa Schumacher, Hans-Willi Mittrücker, Nathalie Jänner
Publikováno v:
The Journal of Immunology. 181:3861-3869
The purinoreceptor P2X7 is expressed on subsets of T cells and mediates responses of these cells to extracellular nucleotides such as ATP or NAD+. We identified P2X7 as a molecule highly up-regulated on conventional CD8αβ+ and unconventional CD8α
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
Autor:
Daniel R. Engel, Oliver M. Steinmetz, Athena Chalaris, Jürgen Scheller, Stefan Rose-John, Hans-Willi Mittrücker, Nathalie Jänner, Judith Hoge, Isabell Yan, Valéa Schumacher
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(2)
The cytokine IL-6 plays a protective role in immune responses against bacterial infections. However, the mechanisms of IL-6–mediated protection are only partially understood. IL-6 can signal via the IL-6R complex composed of membrane-bound IL-6Rα
Autor:
Hans-Willi Mittrücker, Karin Hahnke, Stefan H. E. Kaufmann, Ulrich Steinhoff, Nathalie Jänner, Hans-Joachim Mollenkopf
Publikováno v:
Immunology. 125(1)
The intestinal mucosa represents a challenging environment for CD8+ T cells, which must tolerate nutrient antigens and commensal microorganisms while responding efficiently to pathogens. Consequently, specific regulatory mechanisms apply for CD8+ T c
Autor:
Mischo Kursar, Klaus Pfeffer, Stefan H. E. Kaufmann, Nathalie Jänner, Volker Brinkmann, Hans-Willi Mittrücker
Publikováno v:
European journal of immunology. 38(1)
Activation of naive T cells is tightly controlled and depends on cognate interactions with professional antigen-presenting cells. We analyzed dependency on secondary lymphoid tissues for the activation of naive and memory CD4(+) and CD8(+) T cells fo
Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells
Autor:
Reinhard Bredehorst, Edzard Spillner, Nathalie Jänner, Mark Matzas, Katrin Klensang, Thorsten Mix, Johanna Kölln
Publikováno v:
Molecular immunology. 41(1)
The complement activating venom component Cobra Venom Factor (CVF), a functional and structural homologue of the human complement component C3, forms a stable CVF-dependent C3 convertase complex, which, in contrast to C3-dependent convertase effects
Autor:
Stefan Rose-John, Athena Chalaris, Christoph Garbers, Dörte Meyer, Nathalie Jänner, Jürgen Scheller
Publikováno v:
Cytokine. 52:37