Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry

Autor: Nathalie Hertrich, Christian Ottmann, Alwin M. Hartman, Sebastian A. Andrei, Walid A. M. Elgaher, Anna K. H. Hirsch

Publikováno v: ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, 11(5), 1041-1046. American Chemical Society
ACS medicinal chemistry letters
United States
ACS Med Chem Lett
Bioorganic & Medicinal Chemistry Letters, 11(5), 1041-1046. American Chemical Society

[Image: see text] Protein–protein interactions (PPIs) play an important role in numerous biological processes such as cell-cycle regulation and multiple diseases. The family of 14-3-3 proteins is an attractive target as they serve as binding partne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe455c6a8c3eb7d2241238edd145c2
https://hdl.handle.net/11370/688dfb28-481c-4559-8349-2186dae144d8

Synaptic anchoring of the endoplasmic reticulum depends on myosin V and caldendrin activity

Autor: Nathalie Hertrich, Jeroen Demmers, Anja Konietzny, Marina Mikhaylova, Jasper Grendel, Dick H. W. Dekkers

Excitatory synapses of principal hippocampal neurons are frequently located on dendritic spines. The dynamic strengthening or weakening of individual inputs results in a great structural and molecular diversity of dendritic spines. Active spines with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fb68ceebbe49555db09045a8bafeca4
https://doi.org/10.1101/2020.08.14.250746