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Autor:
Ardjan J. van der Linden, Tfa Tom de Greef, D Wanders, Maarten Merkx, Nathalie Hendrikse, Pascal A. Pieters, Bmg Brian Janssen, M Martijn van Rosmalen
Publikováno v:
Journal of Biological Chemistry, 292(4), 1477-1489. American Society for Biochemistry and Molecular Biology Inc.
Meditopes are cyclic peptides that bind in a specific pocket in the antigen-binding fragment of a therapeutic antibody such as cetuximab. Provided their moderate affinity can be enhanced, meditope peptides could be used as specific non-covalent and p