Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nathalie Dugot‐Senant"'
Autor:
Camille Dantzer, Justine Vaché, Aude Brunel, Isabelle Mahouche, Anne-Aurélie Raymond, Jean-William Dupuy, Melina Petrel, Paulette Bioulac-Sage, David Perrais, Nathalie Dugot-Senant, Mireille Verdier, Barbara Bessette, Clotilde Billottet, Violaine Moreau
Publikováno v:
eLife, Vol 13 (2024)
Immune checkpoint inhibitors have produced encouraging results in cancer patients. However, the majority of ß-catenin-mutated tumors have been described as lacking immune infiltrates and resistant to immunotherapy. The mechanisms by which oncogenic
Externí odkaz:
https://doaj.org/article/342f26d4191d4cf39318d96525b6cc9f
Autor:
Sylvaine Di Tommaso, Cyril Dourthe, Jean-William Dupuy, Nathalie Dugot-Senant, David Cappellen, Hélène Cazier, Valérie Paradis, Jean-Frédéric Blanc, Brigitte Le Bail, Charles Balabaud, Paulette Bioulac-Sage, Frédéric Saltel, Anne-Aurélie Raymond
Publikováno v:
JHEP Reports, Vol 6, Iss 2, Pp 100913- (2024)
Background & Aims: Hepatocellular adenomas (HCAs) are rare, benign, liver tumours classified at the clinicopathological, genetic, and proteomic levels. The β-catenin-activated (b-HCA) subtypes harbour several mutation types in the β-catenin gene (C
Externí odkaz:
https://doaj.org/article/88ae01c559c44a39946de35c754a7779
Autor:
Bertrand Chauveau, Antoine Garric, Sylvaine Di Tommaso, Anne-Aurélie Raymond, Jonathan Visentin, Agathe Vermorel, Nathalie Dugot-Senant, Julie Déchanet-Merville, Jean-Paul Duong Van Huyen, Marion Rabant, Lionel Couzi, Frédéric Saltel, Pierre Merville
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplantation. Defined by the Banff classification, its gold standard diagnosis remains a challenge, with limited inter-observer reproducibility of the
Externí odkaz:
https://doaj.org/article/3388bc24064846ebb66e5222bec96961
Autor:
Caroline Gest, Sandra Sena, Lydia Dif, Véronique Neaud, Robin Loesch, Nathalie Dugot-Senant, Lisa Paysan, Léo Piquet, Terezinha Robbe, Nathalie Allain, Doulaye Dembele, Catherine Guettier, Paulette Bioulac-Sage, Anne Rullier, Brigitte Le Bail, Christophe F. Grosset, Frédéric Saltel, Valérie Lagrée, Sabine Colnot, Violaine Moreau
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100691- (2023)
Background & Aims: β-catenin is a well-known effector of the Wnt pathway, and a key player in cadherin-mediated cell adhesion. Oncogenic mutations of β-catenin are very frequent in paediatric liver primary tumours. Those mutations are mostly hetero
Externí odkaz:
https://doaj.org/article/842490d9fd564a5d9087b3a228132176
Autor:
Margaux Sala, Delphine Gonzales, Thierry Leste‐Lasserre, Nathalie Dugot‐Senant, Valérie Paradis, Sylvaine Di Tommaso, Jean‐William Dupuy, Vincent Pitard, Cyril Dourthe, Amedeo Sciarra, Christine Sempoux, Linda D. Ferrell, Andrew D. Clouston, Gregory Miller, Mathew M. Yeh, Swan Thung, Annette S.H. Gouw, Alberto Quaglia, Jing Han, Ji Huan, Cathy Fan, James Crawford, Yasuni Nakanuma, Kenichi Harada, Brigitte leBail, Claire Castain, Nora Frulio, Hervé Trillaud, Laurent Possenti, Jean‐Frédéric Blanc, Laurence Chiche, Christophe Laurent, Charles Balabaud, Paulette Bioulac‐Sage, Anne Aurélie Raymond, Frédéric Saltel
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 809-824 (2020)
Until recently, 10% of hepatocellular adenomas (HCAs) remained unclassified (UHCA). Among the UHCAs, the sonic hedgehog HCA (shHCA) was defined by focal deletions that fuse the promoter of Inhibin beta E chain with GLI1. Prostaglandin D2 synthase was
Externí odkaz:
https://doaj.org/article/a964102491fb4c51a8bbff73d7a74e81
Autor:
Nicola Mosca, Fatma Zohra Khoubai, Sandrine Fedou, Juan Carrillo-Reixach, Stefano Caruso, Alvaro Del Rio-Alvarez, Emeric Dubois, Christophe Avignon, Nathalie Dugot-Senant, Catherine Guettier, Charlotte Mussini, Jessica Zucman-Rossi, Carolina Armengol, Pierre Thiébaud, Philippe Veschambre, Christophe François Grosset
Publikováno v:
Liver Cancer (2021)
Introduction: Hepatocellular carcinoma and hepatoblastoma are two liver cancers characterized by gene deregulations, chromosomal rearrangements, and mutations in Wnt/beta-catenin (Wnt) pathway-related genes. LHX2, a transcriptional factor member of t
Externí odkaz:
https://doaj.org/article/297a3ba469f4429bbd8e8ca00ff177f5
Autor:
Esra Karatas, Sylvaine Di-Tommaso, Nathalie Dugot-Senant, Alain Lachaux, Marion Bouchecareilh
Publikováno v:
European Medical Journal Hepatology, Vol 7, Iss 1, Pp 65-79 (2019)
Alpha-1 antitrypsin (AAT), encoded by the SERPINA1 gene, is a protein mainly produced and secreted by hepatocytes. Some specific mutations affecting SERPINA1 may cause accumulation of misfolded AAT in the endoplasmic reticulum of the hepatocytes lead
Externí odkaz:
https://doaj.org/article/f9abb2512c9d44fea87c05bfa8e8fa4d
Autor:
Bertrand Chauveau, Anne-Aurélie Raymond, Sylvaine Di Tommaso, Jonathan Visentin, Agathe Vermorel, Nathalie Dugot-Senant, Cyril Dourthe, Jean-William Dupuy, Julie Déchanet-Merville, Jean-Paul Duong Van Huyen, Marion Rabant, Lionel Couzi, Frédéric Saltel, Pierre Merville
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 569 (2022)
Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplantation. Its histological hallmark is represented by lesions of glomerulitis i.e., inflammatory cells within glomeruli. Current therapies for ABMR fail to
Externí odkaz:
https://doaj.org/article/9a5ca9a691d748268da69b7689dcdeec
Autor:
Guillaume Vial, Etienne Rivière, Anne-Aurélie Raymond, Chloé James, Sylvaine Di-Tommaso, Nathalie Dugot-Senant, Jean-William Dupuy, Mokrane Yacoub, Marie Parrens, Fréderic Saltel, Jean-François Viallard
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The association of immune thrombocytopenia (ITP) with cancer has been reported, but the causality of tumor cells in paraneoplastic ITP pathogenesis and maintenance has never been established. We analyzed the unusual case of refractory ITP and coincid
Externí odkaz:
https://doaj.org/article/e77c9a59c6cf42c291466b44a6226249
Autor:
Delphine Fessart, Charlotte Domblides, Tony Avril, Leif A Eriksson, Hugues Begueret, Raphael Pineau, Camille Malrieux, Nathalie Dugot-Senant, Carlo Lucchesi, Eric Chevet, Frederic Delom
Publikováno v:
eLife, Vol 5 (2016)
The extracellular matrix (ECM) plays an instrumental role in determining the spatial orientation of epithelial polarity and the formation of lumens in glandular tissues during morphogenesis. Here, we show that the Endoplasmic Reticulum (ER)-resident
Externí odkaz:
https://doaj.org/article/3876518ea92442c383684c20fc26b282