Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nathalie Delrue"'
Autor:
Miriam N. Jacobs, Jan M. Bult, Kevin Cavanagh, Christophe Chesne, Nathalie Delrue, Jianan Fu, Emma Grange, Ingrid Langezaal, Dominika Misztela, Jenny Murray, Martin Paparella, Gilly Stoddart, Torsten Tonn, Carol Treasure, Masaaki Tsukano, Rosemary Versteegen
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The ethical needs and concerns with use and sourcing of human materials, particularly serum, in OECD in vitro test guidelines were explored in a dedicated international workshop held in 2019. The health-related aspects of the donation procedure, incl
Externí odkaz:
https://doaj.org/article/64e648c9e6894018be64557ad5a4ea22
Autor:
Shihori Tanabe, Jason O’Brien, Knut Erik Tollefsen, Youngjun Kim, Vinita Chauhan, Carole Yauk, Elizabeth Huliganga, Ruthann A. Rudel, Jennifer E. Kay, Jessica S. Helm, Danielle Beaton, Julija Filipovska, Iva Sovadinova, Natalia Garcia-Reyero, Angela Mally, Sarah Søs Poulsen, Nathalie Delrue, Ellen Fritsche, Karsta Luettich, Cinzia La Rocca, Hasmik Yepiskoposyan, Jördis Klose, Pernille Høgh Danielsen, Maranda Esterhuizen, Nicklas Raun Jacobsen, Ulla Vogel, Timothy W. Gant, Ian Choi, Rex FitzGerald
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stres
Externí odkaz:
https://doaj.org/article/6e4603ffc4664fc2936ec3f4a2a4f907
Autor:
Edward J. Perkins, Julie Leblanc, Dominique Laurier, Michael A. Boyd, Vinita Chauhan, Holly Laakso, Sabina Halappanavar, Nathalie Delrue, Ruth C. Wilkins, Jason M. O'Brien, Bette Meek, Russell S. Thomas, Catalina Anghel, Barber Christopher Gordon, Crina Heghes, Julie Burtt, Ted Lazo, Tara S. Barton-Maclaren, Carole L. Yauk, Danielle Beaton, Francesco Marchetti, Donald Cool, Magdalini Sachana, Maurice Whelan, Daniel L. Villeneuve
Publikováno v:
International Journal of Radiation Biology
International Journal of Radiation Biology, Informa Healthcare, 2021, 97 (4), pp.431-441. ⟨10.1080/09553002.2021.1884314⟩
International Journal of Radiation Biology, Informa Healthcare, 2021, 97 (4), pp.431-441. ⟨10.1080/09553002.2021.1884314⟩
International audience; Background: Decades of research to understand the impacts of various types of environmental occupational and medical stressors on human health have produced a vast amount of data across many scientific disciplines. Organizing
Autor:
Marco Corvaro, Paule Vasseur, Monica Vaccari, Annamaria Colacci, Federica Madia, Martin Paparella, Akiyoshi Nishikawa, Nathalie Delrue, Kumiko Ogawa, Norman Ertych, Raffaella Corvi, Miriam N. Jacobs, Kiyomi Ohmori, M. Cecilia Aguila, Mirjam Luijten, Daniel Desaulniers, Anoop Kumar Sharma, Abigail Jacobs
Publikováno v:
Jacobs, M N, Colacci, A, Corvi, R, Vaccari, M, Aguila, M C, Corvaro, M, Delrue, N, Desaulniers, D, Ertych, N, Jacobs, A, Luijten, M, Madia, F, Nishikawa, A, Ogawa, K, Ohmori, K, Paparella, M, Sharma, A K & Vasseur, P 2020, ' Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens ', Archives of Toxicology, vol. 94, no. 8, pp. 2899-2923 . https://doi.org/10.1007/s00204-020-02784-5
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, 94 (8), pp.2899-2923. ⟨10.1007/s00204-020-02784-5⟩
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, 94 (8), pp.2899-2923. ⟨10.1007/s00204-020-02784-5⟩
While regulatory requirements for carcinogenicity testing of chemicals vary according to product sector and regulatory jurisdiction, the standard approach starts with a battery of genotoxicity tests (which include mutagenicity assays). If any of the
Publikováno v:
Current Opinion in Toxicology. 15:18-25
Despite the expansion of methods and technologies available for evaluating the safety of environmental chemicals, the uptake of new approaches and acceptance of alternative data in regulatory contexts have been relatively slow. This may be due to rea
Autor:
Da-Woon Jung, Yooheon Park, Toine F.H. Bovee, Keith A. Houck, Patience Browne, Atsushi Ono, Yun Sook Kang, Masahiro Takeyoshi, Nathalie Delrue, Hee-Seok Lee, Miriam N. Jacobs, Anne Milcamps
Publikováno v:
Food and Chemical Toxicology, 152
Food and Chemical Toxicology 152 (2021)
Food and Chemical Toxicology 152 (2021)
We describe the characterisation and validation of an androgen receptor (AR) transactivation assay for detection of AR agonists and antagonists using a stably transfected human prostate cancer cell line. This 22Rv1/mouse mammary tumour virus glucocor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7178b83e8e01ad510b330ffd60fca28a
https://research.wur.nl/en/publications/characterisation-and-validation-of-an-in-vitro-transactivation-as
https://research.wur.nl/en/publications/characterisation-and-validation-of-an-in-vitro-transactivation-as
Autor:
Silvia Vogl, Ibrahim Chahoud, Marlon R. Schneider, Weihua Li, Gilbert Schönfelder, Martina Rauch, Steffen Schneider, Frank Schulze, A. Gall, Rupert Kellner, Kohei Shiota, Francisco José Roma Paumgartten, Ruth Clark, Jochen Buschmann, Ellen Fritsche, Susan L. Makris, Nathalie Delrue, Anne Schmitt, Roland Solecki, Alberto Mantovani, Makiko Kuwagata, Nicole Kleinstreuer, Jingying Hu, Michio Fujiwara, Olena Kucheryavenko
Publikováno v:
Reprod Toxicol
Representatives of applied science (e.g. governmental organizations, academia, and industry) met to discuss the progress towards a harmonized human health risk assessment in developmental toxicology of plant protection products, biocidal products, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ea670d9cffa622d85024582e42acff
https://publica.fraunhofer.de/handle/publica/259248
https://publica.fraunhofer.de/handle/publica/259248
Autor:
Zvonimir Zvonar, Susan P. Felter, Federica Madia, Katrin Schutte, Ruud A. Woutersen, Abigail Jacobs, Hedwig M. Braakhuis, Jan Willem van der Laan, Gerrit Wolterink, Marco Corvaro, Stephanie Melching-Kollmuss, Irene Manou, Douglas C. Wolf, Franz Lamplmair, Jyotigna Mehta, Raffaella Corvi, Mirjam Luijten, Thomas Holmes, Dick Lewis, Miriam N. Jacobs, Nathalie Delrue, Harm J. Heusinkveld, Bodo Haas, Nicola J. Hewitt, Gina M. Hilton, Frédéric Schorsch, Christian Strupp, Fiona Sewell
Publikováno v:
Regulatory Toxicology and Pharmacology. 118:104789
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive
Autor:
Nathalie Delrue, Yuki Sakuratani, Eeva Leinala, Anne Gourmelon, Robert Diderich, Magdalini Sachana
Publikováno v:
Alternatives to Laboratory Animals. 44:417-429
The Adverse Outcome Pathway (AOP) concept is expected to guide risk assessors in their work to use all existing information on the effects of chemicals on humans and wildlife, and to target the generation of additional information to the regulatory o
Autor:
Aldert H. Piersma, Rex E. FitzGerald, Manuela Tiramani, Florianne Monnet-Tschudi, Helena T. Hogberg, Gabriele Schmuck, Ellen Fritsche, Anna Bal-Price, Sandra Allen, Marcel Leist, Nathalie Delrue, Thomas Hartung, Martin Paparella, Daniela Maria Oggier, Timo Ylikomi, Timo Buetler, Eva Rached, Walter Lichtensteiger, Benoît Schilter, Susanne Hougaard Bennekou, Marta Axelstad, Michael Arand, Kevin M. Crofton, Martin F. Wilks, Tuula Heinonen, Luc Stoppini, Enrico Tongiorgi
Publikováno v:
Bal-Price, A, Crofton, K M, Leist, M, Allen, S, Arand, M, Buetler, T, Delrue, N, FitzGerald, R E, Hartung, T, Heinonen, T, Hogberg, H, Bennekou, S H, Lichtensteiger, W, Oggier, D, Paparella, M, Petersen, M A, Piersma, A, Rached, E, Schilter, B, Schmuck, G, Stoppini, L, Tongiorgi, E, Tiramani, M, Monnet-Tschudi, F, Wilks, M F, Ylikomi, T & Fritsche, E 2015, ' International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes ', Archives of Toxicology, vol. 89, no. 2, pp. 269-287 . https://doi.org/10.1007/s00204-015-1464-2
Archives of Toxicology, vol. 89, no. 2, pp. 269-287
Archives of Toxicology
Archives of Toxicology, vol. 89, no. 2, pp. 269-287
Archives of Toxicology
A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisi