Výsledky vyhledávání - "Nathalie Dekeersmaeker"

Characterization of amino acids Arg, Ser and Thr at position 70 within HIV-1 reverse transcriptase

Autor: Jean A. Bernatchez, K. Van Laethem, Kris Covens, Ricardo Jorge Camacho, Anne-Mieke Vandamme, Lore Vinken, Nathalie Dekeersmaeker, Sarah Megens, Matthias Götte, Kristof Theys, S De Wit

Publikováno v: Acta Clinica Belgica. 69:348-357

The amino acid position 70 in HIV-1 reverse transcriptase (RT) plays an important role in nucleoside RT inhibitor (NRTI) resistance. K70R is part of the thymidine analog mutations, but also other amino acid changes have been associated with NRTI resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d43eed8f2cba21f7a3e2c648b4030b
https://doi.org/10.1179/2295333714y.0000000038

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Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits

Autor: Sarah Megens, Frederic Rousseau, Dolores Vaira, Guangdi Li, Nathalie Dekeersmaeker, Kristel Van Laethem, Joost Schymkowitz, Anne-Mieke Vandamme, Yoeri Schrooten, Michel Moutschen, Greet De Baets

Publikováno v: Virology. :310-318

We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I). Concu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa679b8eda97b7fbfdd387b0f70fb98b

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Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba

Publikováno v: Infection, Genetics and Evolution. 16:144-150

In Cuba, antiretroviral therapy rollout started in 2001 and antiretroviral therapy coverage has reached almost 40% since then. The objectives of this study were therefore to analyze subtype distribution, and level and patterns of drug resistance in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e33fd808a3dd314c766a0da54fb84d
https://doi.org/10.1016/j.meegid.2013.02.002

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High frequency of antiviral drug resistance and non-B subtypes in HIV-1 patients failing antiviral therapy in Cuba

Autor: Delmis Álvarez, Vivian Kourí, Stijn Imbrechts, Nathalie Dekeersmaeker, Daniel Pérez, Jorge Luis Tórtora Pérez, Lore Vinken, Kristel Van Laethem, Carlos Aragonés, Carlos Fonseca, Yudira Soto, Alina Álvarez, Anne-Mieke Vandamme, Yoan Alemán, Lissette Pérez, Consuelo Correa, Jorge Campos, Gertjan Beheydt, Yoeri Schrooten

Publikováno v: Journal of Clinical Virology. 55:348-355

a b s t r a c t Background: Emergence of HIV-1 drug resistance may limit the sustained benefits of antiretroviral therapy (ART) in settings with limited laboratory monitoring and drug options. Objectives: Surveillance of drug resistance and subtypes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7000306240325359b49e75474c79b9b9
https://doi.org/10.1016/j.jcv.2012.08.019

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The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide

Autor: Stéphane De Wit, Nathalie Dekeersmaeker, Sarah Megens, Kristel Van Laethem, Kris Covens, Anne-Mieke Vandamme, Kabamba Kabeya, Jan Balzarini

Publikováno v: Antiviral Research. 86:253-260

Mutations that are selected at low frequency and/or reside outside the enfuvirtide target region, amino acid 36–45 of gp41, might still be important determinants for drug resistance. This study aimed to investigate the phenotypic impact against enf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84fef4ff374380df5b8732d0d3fd9c7
https://doi.org/10.1016/j.antiviral.2010.03.003

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Novel Recombinant Virus Assay for Measuring Susceptibility of Human Immunodeficiency Virus Type 1 Group M Subtypes To Clinically Approved Drugs

Autor: Dominique Schols, Kris Covens, Jan Weber, Anne-Mieke Vandamme, Nathalie Dekeersmaeker, Kristel Van Laethem, Yoeri Schrooten, Miguel E. Quiñones-Mateu

Publikováno v: Journal of Clinical Microbiology. 47:2232-2242

Combination therapy can successfully suppress human immunodeficiency virus (HIV) replication in patients but selects for drug resistance, requiring subsequent resistance-guided therapeutic changes. This report describes the development and validation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f1826e93f9ff48f28bc44d56bcec7c
https://doi.org/10.1128/jcm.01739-08

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Evolution of genotypic resistance to enfuvirtide in HIV-1 isolates from different group M subtypes

Autor: Kabamba Kabeya, Anne-Mieke Vandamme, Nathalie Dekeersmaeker, Eric Van Wijngaerden, Yoeri Schrooten, Kristel Van Laethem, Kris Covens, Stéphane De Wit

Publikováno v: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 44(4)

Background: Enfuvirtide is active against isolates from different HIV-1 subtypes. In vitro and in vivo studies reveal that resistance mutations are primarily found within the region spanning amino acid 36–45 of gp41. However, most studies include o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f03ad9d0fec9a81115bb1ee1bd9452
https://pubmed.ncbi.nlm.nih.gov/19237313

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A genotypic assay for the amplification and sequencing of integrase from diverse HIV-1 group M subtypes

Autor: Eric Van Wijngaerden, Marc Van Ranst, Nathalie Dekeersmaeker, Kris Covens, Kristel Van Laethem, Yoeri Schrooten, Anne-Mieke Vandamme, Paul De Munter

Publikováno v: Journal of virological methods. 153(2)

Recently, the Food and Drug Administration (FDA) of the USA approved the first integrase inhibitor for inclusion in treatment regimens of HIV-1 patients failing their current regimens with multi-drug resistant strains. However, treatment failure has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f068b7ca8ead00305ab7722834db34f1
https://pubmed.ncbi.nlm.nih.gov/18706932

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Subgroup prevalence and genotype circulation patterns of human respiratory syncytial virus in Belgium during ten successive epidemic seasons

Autor: Kalina T. Zlateva, Marc Van Ranst, Leen Vijgen, Cecilia Naranjo, Nathalie Dekeersmaeker

Publikováno v: Journal of clinical microbiology. 45(9)

Human respiratory syncytial virus (HRSV) is the leading viral cause of severe respiratory illness for infants and young children worldwide. Two major antigenic groups (A and B) of HRSV exist, and viruses from both subgroups can cocirculate during epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839f3afc0941ad83cae311d356b51b0b
https://pubmed.ncbi.nlm.nih.gov/17609323

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