Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Nathalie Dehne"'
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 3075-3086 (2016)
Post-translational modification of proteins with ubiquitin-like SUMO modifiers is a tightly regulated and highly dynamic process. The SENP family of SUMO-specific isopeptidases comprises six cysteine proteases. They are instrumental in counterbalanci
Externí odkaz:
https://doaj.org/article/8ffcf9bb92564c1aa142ea98a1e0a570
Publikováno v:
Redox Biology, Vol 5, Iss , Pp 419- (2015)
Background: Tumor associated macrophages (TAMs) are known to support tumor progression and their accumulation is generally associated with poor prognosis. The shift from a tumor-attacking to a tumor-supportive macrophage phenotype is based on an educ
Externí odkaz:
https://doaj.org/article/870c0928d3334fbda48800ce998aba85
Autor:
Ingo Ebersberger, Annika F Fink, Arpit Jain, Dominik C. Fuhrmann, Rebekka Bauer, Catherine Olesch, Tobias Schmid, Rosa M Susen, Bernhard Brüne, Nathalie Dehne
Publikováno v:
Molecular Carcinogenesis. 58:2127-2138
In solid tumors, tumor-associated macrophages (TAMs) commonly accumulate within hypoxic areas. Adaptations to such environments evoke transcriptional changes by the hypoxia-inducible factors (HIFs). While HIF-1α is ubiquitously expressed, HIF-2α ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cee8cf6f361f541a4c6d815017a00f
https://doi.org/10.1002/mc.23103
https://doi.org/10.1002/mc.23103
Autor:
Bernhard Brüne, Dominik C. Fuhrmann, Stefan Dröse, Ilka Wittig, Tobias Schmid, Nathalie Dehne
Publikováno v:
Cellular and Molecular Life Sciences. 75:3051-3067
Cell stress such as hypoxia elicits adaptive responses, also on the level of mitochondria, and in part is mediated by the hypoxia-inducible factor (HIF) 1α. Adaptation of mitochondria towards acute hypoxic conditions is reasonably well understood, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8456cff720ceba0e95550d6c1057c0
https://doi.org/10.1007/s00018-018-2779-y
https://doi.org/10.1007/s00018-018-2779-y
Autor:
Kristoffer von Stedingk, Nathalie Dehne, Bernhard Brüne, Anica Scholz, Tobias Schmid, Sofia Winslow, Thilo F. Brauß, Andreas Weigert, Sebastian Lampe
Publikováno v:
Molecular Carcinogenesis. 56:2620-2629
The RNA-binding protein HuR promotes tumor growth by affecting proliferation, metastasis, apoptosis, and angiogenesis. Although immune cells, especially tumor-associated macrophages, are critical components of the tumor stroma, the influence of HuR i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a08edc1058e6001aac5b3af2a4c87bc
https://doi.org/10.1002/mc.22706
https://doi.org/10.1002/mc.22706
Publikováno v:
Antioxidants & Redox Signaling. 26:1023-1043
Leukocytes and especially macrophages are a major cellular constituent of the tumor mass. The tumor microenvironment not only determines their activity but in turn these cells also contribute to tumor initiation and progression. Recent Advances: Proi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6875a317aa895a3b1f8f88e316970d99
https://doi.org/10.1089/ars.2016.6811
https://doi.org/10.1089/ars.2016.6811
Autor:
Josef Pfeilschifter, Tzung-Harn Louise Hsieh, Mohamed Ibrahim Abu Hassan, Martina Beck, Ahmed Aglan, Meike Boosen, Nathalie Dehne, Sebastian Longen, Liliana Schaefer, Yvette Köhler, Claudia Tredup, Karl-Friedrich Beck
Publikováno v:
Journal of Molecular Medicine. 95:257-271
Renal mesangial cells are regarded as main players in glomerular inflammatory diseases. To investigate a possible crosstalk between inflammatory and hypoxia-driven signaling processes, we stimulated cultured mouse mesangial cells with different infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca8e98447a1ada9a9c7686a58f4ecc8
https://doi.org/10.1007/s00109-016-1503-3
https://doi.org/10.1007/s00109-016-1503-3
Autor:
Jonathan Jantsch, Bernhard Brüne, Jennifer M. McNiff, Maximilian J. Waldner, Yannic Strüssmann, Uwe Ritter, Christian Bogdan, Jens Wild, Valentin Schatz, Carsten Willam, Alexander Mahnke, Gunnar Schley, Oscar R. Colegio, Nathalie Dehne
Publikováno v:
J Immunol
Hypoxia-inducible factor-1α (HIF-1α), which accumulates in mammalian host organisms during infection, supports the defense against microbial pathogens. However, whether and to what extent HIF-1α expressed by myeloid cells contributes to the innate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de28c369f33321a0bed0965eae1dea7
https://doi.org/10.4049/jimmunol.1601080
https://doi.org/10.4049/jimmunol.1601080
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model
Autor:
Martina G. Ding, Bernhard Brüne, Gerd Geisslinger, Nina Henke, Dominik C. Fuhrmann, Dmitry Namgaladze, Theresa Geis, Nathalie Dehne, Nerea Ferreirós, Silke Essler
Publikováno v:
Oncotarget
Activation of hypoxia-inducible factor (HIF) and macrophage infiltration of solid tumors independently promote tumor progression. As little is known how myeloid HIF affects tumor development, we injected the polycyclic aromatic hydrocarbon (PAH) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f928a2ff78c4f8e5ccca5d964145923
http://europepmc.org/articles/PMC5041954
http://europepmc.org/articles/PMC5041954
Autor:
Nathalie Dehne, Gerd Geisslinger, Nina Grossmann, Bernhard Brüne, Carlo Angioni, Dmitry Namgaladze, Ryan G. Snodgrass
Publikováno v:
Journal of Biological Chemistry. 290:24484-24494
Macrophages respond to the Th2 cytokine IL-4 with elevated expression of arachidonate 15-lipoxygenase (ALOX15). Although IL-4 signaling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammatory processes in a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f206cea45aeb8333c2ef0622318de5d
https://doi.org/10.1074/jbc.m115.678243
https://doi.org/10.1074/jbc.m115.678243