Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nathalie Coulombe"'
Autor:
Sophie Broussau, Viktoria Lytvyn, Mélanie Simoneau, Claire Guilbault, Mélanie Leclerc, Nazila Nazemi-Moghaddam, Nathalie Coulombe, Seyyed Mehdy Elahi, Scott McComb, Rénald Gilbert
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 40-57 (2023)
Lentiviral vectors (LVs) are important for cell therapy because of their capacity to stably modify the genome after integration. This study describes a novel and relatively simple approach to generate packaging cells and producer clones for self-inac
Externí odkaz:
https://doaj.org/article/b29e66448da141bab4743b93d453e19e
Rapid In-Process Monitoring of Lentiviral Vector Particles by High-Performance Liquid Chromatography
Autor:
Julia Transfiguracion, Michelle Yen Tran, Stéphane Lanthier, Sonia Tremblay, Nathalie Coulombe, Mauro Acchione, Amine A. Kamen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 803-810 (2020)
Lentiviral vectors (LVs) are a popular gene delivery tool in cell and gene therapy and they are a primary tool for ex vivo transduction of T cells for expression of chimeric antigen receptor (CAR) in CAR-T cell therapies. Extensive process and produc
Externí odkaz:
https://doaj.org/article/0d0c01f148ad488f843562142adf1fef
Autor:
Dita M. Rasper, Sophie Roy, Elizabeth M. Simpson, Donald W. Nicholson, Erich L. Grimm, Caroline Houde, Nathalie Coulombe, Kathleen G. Banks
Publikováno v:
The Journal of Neuroscience. 24:9977-9984
Caspase-3-deficient mice of the 129S1/SvImJ (129) strain show severe brain development defects resulting in brain overgrowth and perinatal lethality, whereas on the C57BL/6J (B6) background, these mice develop normally. We therefore sought to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74832063ab2e031aad88ae9ecf70f7c
https://doi.org/10.1523/jneurosci.3356-04.2004
https://doi.org/10.1523/jneurosci.3356-04.2004
Autor:
Steven Xanthoudakis, Sophie Roy, Yongxin Han, John Colucci, Sylvie Toulmond, Nathalie Coulombe, Nathalie Méthot, Donald W. Nicholson, Robert Zamboni, JingQi Huang, John P. Vaillancourt, Dita M. Rasper, John Tam
Publikováno v:
The Journal of Experimental Medicine
A rodent model of sepsis was used to establish the relationship between caspase inhibition and inhibition of apoptotic cell death in vivo. In this model, thymocyte cell death was blocked by Bcl-2 transgene, indicating that apoptosis was predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac87d1bba6920acb8025aeb38cc0881
http://europepmc.org/articles/PMC2211770
http://europepmc.org/articles/PMC2211770
Autor:
Amine Kamen, Parminder S. Chahal, Nathalie Coulombe, Stéphane Lanthier, Rénald Gilbert, Alice Bernier, Érica Alessandra Schulze
Publikováno v:
Molecular Therapy. 24:S117-S118
Adeno-Associated Virus (AAV) vectors showing safety profile in phase I clinical trials and its ability to transduce gene expression in various tissues have made it a vector of choice for gene delivery. There are different modes of AAV vector producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::360d0ec5ca04358bbe3df422647c188d
https://doi.org/10.1016/s1525-0016(16)33101-x
https://doi.org/10.1016/s1525-0016(16)33101-x
Autor:
Qingyun Liu, Tuan V. Nguyen, David J. Figueroa, Rino Stocco, Kevin R. Lynch, Mark Abramovitz, Lei Ma, Jilly F. Evans, Dong Soon Im, Regina Cheng, Christopher P. Austin, Susan R. George, Brian F. O'Dowd, Zhizhen Zeng, Christopher E. Heise, Nathalie Coulombe, Michelle K. Clements, Julie N. Bellefeuille, Kathleen M. Metters, Gary P. O'Neill, David L. Williams, Yuan Liu, Nicole Sawyer
Publikováno v:
Journal of Biological Chemistry. 275:30531-30536
The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC(4), LTD(4), and LTE(4), are thought to be mediated through at least two distinct but related CysLT G protein-coupled receptors. The human CysLT(1) receptor has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd76060878f2f855a0e2a3d552824645
https://doi.org/10.1074/jbc.m003490200
https://doi.org/10.1074/jbc.m003490200
Autor:
Marie-France Palin, Frederick G. Silversides, Robert M. Mckay, Bernard F. Benkel, Ghislain Pelletier, Claude Roberge, Claude Robert, Nathalie Coulombe
Publikováno v:
Canadian Journal of Animal Science. 78:473-482
The obese (ob) gene isolated from ob/ob mice in 1994 is expressed specifically in adipose tissue. The gene product, leptin, regulates food intake, energy expenditure and puberty. Reported herein is a 2477 bp mRNA sequence for the pig obese gene, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2ac2cafed598ca4bbdf749cbb302e1
https://doi.org/10.4141/a98-072
https://doi.org/10.4141/a98-072
Publikováno v:
DNA and Cell Biology. 16:993-1002
A CYP11B2 gene encoding cytochrome P450 aldosterone synthase (P450aldo) was isolated from a hamster genomic library. The gene, which contained 9 exons, was composed of 9,045 bp, of which 3,722 bp were located in the 5' untranslated region (5' UTR). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2233cd7c2c7e0cc9f1066dae673163b0
https://doi.org/10.1089/dna.1997.16.993
https://doi.org/10.1089/dna.1997.16.993
Autor:
Nguyen Natalie, Ernest Asante-Appiah, Manuel Chan, Nathalie Coulombe, Yves Ducharme, Mark Wrona, C. Bayly, Paul Tawa, Serge Plamondon, Kristina Dupont-Gaudet, Amandine Chefson, Jean-François Truchon, Sébastien Guiral, Louis-Charles Campeau, Joe Vacca, Sébastien Gagné, Rob Papp, Elizabeth Cauchon, Leanne Bedard, Eric Langlois, Robert Forget, Stéphane G. Ouellet, Stephanie Roy, Mélina Girardin, Jason Burch, Jean-Pierre Falgueyret, Bernard Cote, Danny Gauvreau, St-Onge Miguel, Marc Blouin, Ria Seliniotakis, Wanda Cromlish, Chun Sing Li, Amélie Roy, Smita Debnath, Youwei Yan, Denis Deschenes
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(3)
The optimization of a novel series of non-nucleoside reverse transcriptase inhibitors (NNRTI) led to the identification of pyridone 36. In cell cultures, this new NNRTI shows a superior potency profile against a range of wild type and clinically rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62223ea91d052361c00f8debcf009fe0
https://pubmed.ncbi.nlm.nih.gov/24412110
https://pubmed.ncbi.nlm.nih.gov/24412110
Autor:
Susana Liu, Nathalie Coulombe, René St-Jacques, Jacques Yves Gauthier, Jean-François Fournier, M. David Percival, Sylvie Desmarais, Wanda Cromlish, Sylvie Toulmond
Publikováno v:
Biological chemistry. 391(12)
Renin is the first enzyme in the renin-angiotensin-aldosterone system which is the principal regulator of blood pressure and hydroelectrolyte balance. Previous studies suggest that cathepsin B is the activator of the prorenin zymogen. Here, we show n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecb7a5c9bcec9f67c37d0d757bf74d5
https://pubmed.ncbi.nlm.nih.gov/20868234
https://pubmed.ncbi.nlm.nih.gov/20868234